White Papers / Tech Papers

Kaneka Probiotics offers a portfolio of science-based probiotic strains for targeted health applications. Its strain library collection has more than 1,000 different strains strategically sourced from rural areas and populations with good health yet little exposure to modern lifestyle and amenities. Published clinical trials back products and are designed to utilize the actual trial dosages in the finished commercial products. The acid-resistant, strains offer superior efficacy for a variety of targeted health conditions including Cardio, Intensive GI, Digestive, Oral Health, Immune Defense, Baby Colic, Brain, Mood/Anxiety, Urinary Tract and Vaginal Health.

Kaneka is a leader in the development of scientifically based ingredients for the global nutrition industry. Kaneka is committed to promoting business development to provide solutions that support healthy and energetic lives.


Kaneka Probiotics’ Intensive G.I. is a multi-strain formula that helps to protect against everyday gut related anxiety and discomfort.The clinically tested blend contains three unique strains of Pediococcus pentosaceus, and two strains of Lactobacillus plantarum. Its unique mechanism of action consists of: Three strains optimized for Gut Health. A synergistic blend of three strains with multiple mechanisms documented in vitro associated with a healthy gut/GI tract. In addition, the strains were shown to be strong producers of short chain fatty acids acetate, propionate and butyrate.


Kaneka Probiotics’ Mood and Stress. Many strains of lactic acid bacteria (LAB) from the genus of Lactobacillus have been identified to possess probiotic properties. They have been much emphasized for their roles to regulate gut well-being. Recent published studies have illustrated the potential for Lactobacillus plantarum DR7 for supporting cognitive health, including protection against negative effects associated with stress and anxiety.


Kaneka Probiotics’ Cardiovascular Health Kaneka Probiotics’ Cardio is an IP-protected and patented probiotic formulation developed to improve the metabolism of cholesterol in the blood. Its formulation contains three clinical strains and there have been two published clinical trials (randomized, double-blind, placebo-controlled design). Kaneka Probiotics’ formula contains three unique strains of Lactobacillus plantarum. Triple Strength for Heart Health. Promotes Healthy Total Cholesterol Levels for those already within normal range, LDL Cholesterol (harmful cholesterol), Triglycerides. These specific, triple Lactobacillus plantarum strains showed a robust capability to sur­vive under harsh gastrointestinal tract (GI) conditions, including exposures to acids and bile. In addition, these specific strains were demonstrated to adhere to intestinal epithe­lial cells. In terms of lipid metabolism, the strains showed a particular ability to produce large amounts of bile salt hydrolase. Bile salts are responsible for recirculating choles­terol systemically. By hydrolyzing the bile-salt molecule, which contains cholesterol, the re-uptake of cholesterol into the body is impacted.


Kaneka Probiotics’ Baby Colic is a patented probiotic with clinically demonstrated effect in reduction of excessive crying due to infant colic. Its formulation contains two clinical strains and there have been two published clinical trials (randomized, double-blind, placebo controlled design). Kaneka Probiotics’ Baby Colic formula contains two unique strains of Pediococcus pentosaceus and Bifidobacterium longum. Unique mechanism of action promotes the positive microbiota (Bifidobacterium and Lactic Acid), Homofermentative metabolism strains selected for Baby Colic do not produce CO2, efficacy demonstrated in breast-feeding and formula-feeding infants; reduced crying-time by more than 60% after only 2 weeks.


Kaneka Probiotics’ Immune Defense is a probiotic formula developed to strengthen the body’s immune defenses to provide protection during stress. Its formulation contains two clinical strains and there have been three published clinical trials (randomized, double-blind, placebo-controlled design). Kaneka Probiotics’ Immune Defense is a combination of probiotics, vitamins and minerals contributing to the normal function of the immune system. PROBIOTICS: 2 Lactobacillus plantarum (CECT 7315 & CECT 7316) + VITAMINS AND MINERALS (50% RDA): Folic acid, Pyridoxine, Cyanocobalamin, Ascorbic Acid, Zinc, Selenium, Retinol. These clinical strains and nutrients enhance the immune response in the body, and their site of activity is in the intestines. The intestinal compartment is the most extensive and complex part of the immune system, and up to 80% of the immune cells of the body are located around the intestinal mucosa at any point of time. As a result, the intestinal mucosa is a key factor in the modulation of the overall immune system.

Kaneka Probiotics’ Oral Health is a probiotic formula developed to improve oral microflora. Its formulation contains three clinical strains. Three randomized, double-blind, placebo-controlled, clinical trial and a series of in vitro studies show the ability of Kaneka Probiotics’ Oral Health strains L. plantarum KABP™-051, L. brevis KABP™-052 and P. acidilactici KABP™-053 to benefit oral health. Brushing removes only a fraction of oral bacteria. Rinsing mouthwashes further reduce, but do not eliminate oral bacteria. Rinsing and brushing reduce both good and bad bacteria. The remaining bacteria grow again, forming harmful biofilms. Oral microbiota is composed of hundreds of bacterial species. Kaneka Probiotics’ Oral Health contains Clinical Strains™ that balance oral microflora. The stains used in the Kaneka Probiotics’ Oral Health formula were isolated via a screening process specifically designed to identify strains that have a beneficial effect on oral health while also showing the ability to withstand in oral cavity conditions (Bosch et al. 2012). The Kaneka Gum Health formula strains KABP™-051, KABP™-052 and KABP-053 have been patented under U.S. patent 2012/022773 A1 for use in oral health.