10.25.22
A three-strain probiotic formula marketed by Kaneka Probiotics as Floradapt Intensive GI was evidenced to benefit stomach and mood symptoms in a population of healthy subjects who experienced self-reported conditions similar to irritable bowel syndrome (IBS), which is often linked to stress, depression, or anxiety.
Twenty-six female and 34 male volunteers between the ages of 20 and 65 were selected for a study, appearing in Heliyon, in which they were randomly assigned to take either a daily dose of the probiotic or a placebo for four weeks. The probiotic blend contained P. acidilactici KABP 021, L. plantarum KABP 022, and L. plantarum KABP 023.
After the month-long intervention, participants who received the probiotic formula saw significant reductions in self-reported stress-related diarrhea and total diarrhea scores compared to placebo, as evaluated by a test called the Izumo scale. These subjects also reported improved scores in the health-related quality-of-life (QOL) measured through the SF-8 questionnaire, suggesting an uptick in mental health and wellbeing during the course of the study.
The authors suggested that the formulation counteracted the damaging effects of stress on the intestinal mucosa by producing metabolites, such as polyphosphates, acetylcholine, or acetate, which are known to reduce intestinal permeability and gut inflammation, with positive GI benefits.
The researchers also found a significant correlation between increased numbers of butyric acid-producing Faecalibacterium prausnitzii and improvement in diarrhea scores in subjects receiving probiotics, but not in the placebo group. Faecalibacterium is stimulated by acetic acid, one of the substances produced by the probiotic formulation.
The authors proposed that the probiotic intervention directly reduced intestinal permeability and modulated gut microbiota, supporting beneficial bacteria, such as Faecalibacterium, and contributed to normalized gut-brain axis.
Previous research concluded that Floradapt Intensive GI improved visceral hypersensitivity, a component of IBS involving altered perceptions of GI symptoms.
“This study significantly advances the level of innovation in the gut-brain space by demonstrating Intensive GI’s unique mechanisms of action impacting gut health as well as mental wellbeing. The Intensive GI formula will provide a multi-mechanism edge for dietary supplement brands seeking to innovate in the hyper-competitive probiotics category,” said Mike Kolifrath, vice president of sales and marketing.
Twenty-six female and 34 male volunteers between the ages of 20 and 65 were selected for a study, appearing in Heliyon, in which they were randomly assigned to take either a daily dose of the probiotic or a placebo for four weeks. The probiotic blend contained P. acidilactici KABP 021, L. plantarum KABP 022, and L. plantarum KABP 023.
After the month-long intervention, participants who received the probiotic formula saw significant reductions in self-reported stress-related diarrhea and total diarrhea scores compared to placebo, as evaluated by a test called the Izumo scale. These subjects also reported improved scores in the health-related quality-of-life (QOL) measured through the SF-8 questionnaire, suggesting an uptick in mental health and wellbeing during the course of the study.
The authors suggested that the formulation counteracted the damaging effects of stress on the intestinal mucosa by producing metabolites, such as polyphosphates, acetylcholine, or acetate, which are known to reduce intestinal permeability and gut inflammation, with positive GI benefits.
The researchers also found a significant correlation between increased numbers of butyric acid-producing Faecalibacterium prausnitzii and improvement in diarrhea scores in subjects receiving probiotics, but not in the placebo group. Faecalibacterium is stimulated by acetic acid, one of the substances produced by the probiotic formulation.
The authors proposed that the probiotic intervention directly reduced intestinal permeability and modulated gut microbiota, supporting beneficial bacteria, such as Faecalibacterium, and contributed to normalized gut-brain axis.
Previous research concluded that Floradapt Intensive GI improved visceral hypersensitivity, a component of IBS involving altered perceptions of GI symptoms.
“This study significantly advances the level of innovation in the gut-brain space by demonstrating Intensive GI’s unique mechanisms of action impacting gut health as well as mental wellbeing. The Intensive GI formula will provide a multi-mechanism edge for dietary supplement brands seeking to innovate in the hyper-competitive probiotics category,” said Mike Kolifrath, vice president of sales and marketing.
