• Protect antibiotic formulations from moisture
• Enhances storage stability and shelf life
• Improves the flow and liquid dispersion properties of powder formulations
Solving the Moisture Challenge
Beta-lactam antibiotics such as Amoxicillin, Cefuroxime, and Cefixime are often formulated with Potassium Clavulanate to avoid degradation from β-lactamase enzymes. Potassium Clavulanate is highly hygroscopic in nature and is hydrolyzed in the presence of moisture, which ultimately affects the efficiency of the antibiotics. As a result, manufacturers of β-lactam antibiotics look to dry powder formulations which can be easily converted to liquid suspension before administration.
The challenge is to stabilize the antibiotics in this powder form. Grace’s SYLOID® AL1-FP silica works as a uniquely effective moisture absorbent that helps maintain stability while SYLOID® 244FP silica is commonly used to maintain powder flow, uniformity, and to help prevent caking.
• Enhances storage stability and shelf life
• Improves the flow and liquid dispersion properties of powder formulations
Solving the Moisture Challenge
Beta-lactam antibiotics such as Amoxicillin, Cefuroxime, and Cefixime are often formulated with Potassium Clavulanate to avoid degradation from β-lactamase enzymes. Potassium Clavulanate is highly hygroscopic in nature and is hydrolyzed in the presence of moisture, which ultimately affects the efficiency of the antibiotics. As a result, manufacturers of β-lactam antibiotics look to dry powder formulations which can be easily converted to liquid suspension before administration.
The challenge is to stabilize the antibiotics in this powder form. Grace’s SYLOID® AL1-FP silica works as a uniquely effective moisture absorbent that helps maintain stability while SYLOID® 244FP silica is commonly used to maintain powder flow, uniformity, and to help prevent caking.
