• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Nutraceuticals for Men: Muscle Health and Performance Nutrition

    Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions

    Getting an Edge in Esports: Meeting the Health Needs of Competitive Gamers

    Beyond CBD: Cannabis Compounds Warrant Recognition and More Research

    Leveling Out the Energy Segment for Mainstream, and Rethinking Caffeine
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Jordan Process Receives Nutrasource ICAP Certification for CBD

    FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Supplements

    Nootropics and Adaptogens Respond to Demand for Mind and Mood Support

    Sabinsa Honors 70th Anniversary of Diplomacy Between India and Japan

    Solvay Invests in Suanfarma’s Vanillin Production
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Jordan Process Receives Nutrasource ICAP Certification for CBD

    Nootropics and Adaptogens Respond to Demand for Mind and Mood Support

    Sabinsa Honors 70th Anniversary of Diplomacy Between India and Japan

    Solvay Invests in Suanfarma’s Vanillin Production

    Tocotrienols May Aid Weight Loss and Cognitive Performance, Animal Study Finds
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Jordan Process Receives Nutrasource ICAP Certification for CBD

    Senate Bill to Reauthorize FDA User Fees Includes Dietary Supplement Listing Provision

    FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Supplements

    Nootropics and Adaptogens Respond to Demand for Mind and Mood Support

    Sabinsa Honors 70th Anniversary of Diplomacy Between India and Japan
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Supplements

    Nootropics and Adaptogens Respond to Demand for Mind and Mood Support

    Experts Debate Role of Supplements in Improving Public Health in EU

    GNC Adds Products from The Honest Company, Hers, and Womaness

    Tocotrienols May Aid Weight Loss and Cognitive Performance, Animal Study Finds
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    PhytoGaia Inc

    Xsto Solutions

    Sabinsa Corporation

    KLK OLEO

    ESHA Research
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    PhytoGaia Inc

    Xsto Solutions

    Sabinsa Corporation

    KLK OLEO

    ESHA Research
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Columns

    Trade-Offs Between Anti-Aging Supplementation & Clinical Evidence

    Epidemiological studies suggest several classes of nutrients offer a protective effect against indicators of aging, such as cognitive decline.

    Trade-Offs Between Anti-Aging Supplementation & Clinical Evidence
    The aging process includes the accumulation of changes over time and a decline in response to these changes.
    Related CONTENT
    • Marine Stewardship Council Calls for Increased Sustainability in Fish Oil Production
    • NSF International Launches Raised Without Antibiotics Certification
    • Food to Feed the Brain
    • ‘Innovate or Die’
    • Influencing the Microbiota-Gut-Brain Axis Through Diet
    Dilip Ghosh, PhD, FACN, nutriConnect05.01.15
    Successful and healthy aging is one of the most important needs of our aging population. At present, worldwide, the number of people aged over 60 and 80 years has reached 671 million and 80 million, respectively. Aging of the population is even more prevalent in “developed” countries. Indeed, 21% of the European population and 17% of the North American population is over 60 years old, whereas half of the population over 80 years old is living in Europe or North America. These numbers are expected to grow rapidly, according to the United Nations World Population Prospects (2012).

    Anti-aging research has made headlines in recent years, and several corporations around the world have exploited the popular press’ fascination with the prospect of rejuvenating and extending life. This potential path to the fountain of youth first appeared in 1999, with the suggestion that lifespan was dramatically extended in yeast bearing an extra copy of sirtuin, the conserved enzyme class.

    Sirtuin & Resveratrol
    Sirtuins are responsible for the health- and longevity-enhancing effects of calorie restriction regimens that have been shown to extend healthy lifespan 40% or more in many organisms, including mice and rats.

    Resveratrol, a compound found in red wine, mimics calorie restriction by activating the sirtuins and extending the healthy lifespan of animals. Whether resveratrol actually activates the sirtuins is hotly debated. In 2005, two research articles published in the Journal of Biological Chemistry (JBC) cast doubt on resveratrol’s ability to activate sirtuins in vivo.

    Despite these negative publications, no one is saying the sirtuins aren’t important. Gerontologists believe that Sir2 is a conserved regulator of longevity. Biogerontologists hoped that calorie restriction would reveal the causes of aging, and that’s what made the sirtuin story so attractive. But calorie restriction is still snatching our attention.

    Oxidative Stress & Antioxidant Stories
    The aging process includes the accumulation of changes over time and a decline of the organism’s response to these changes. A general feature of the aging, or senescence, process is a progressive, physiological deterioration over time leading to an impairment of homeostasis, vulnerability to diseases and ultimately to death of the organism.

    There are numerous hypotheses that attempt to explain the aging process, considering complex physiological alterations in organisms, including: mitochondrial changes, accumulation of aberrant proteins in the cytosol, chemical damage to macromolecules, and somatic mutations. None of these theories have been generally accepted. The oxidative stress hypothesis offers the best mechanistic elucidation of the aging process and other age-related phenomena such as age-related diseases.

    Many scientific efforts have been undertaken to establish if antioxidant supplements may prevent the aging process and prolong human life. Antioxidants seem to be one of the most researched topics in the world, and the most adequately researched clinical question. Beta-carotene, vitamin A, vitamin C, vitamin E and selenium became the most extensively studied medical interventions to retard biological aging phenomenon, but evidence is still inconclusive.

    Hormone Replacement Therapy
    One of the pillars of anti-aging practices is hormone replacement. Decreased secretion of hormones from the pituitary gland, adrenals and gonads is very common with age and has significant effects on skin aging while also decreasing lean body mass, bone mineral density, sexual desire and erectile function, intellectual activity, and mood.

    Phytohormones, particularly isoflavones, can act as steroidal mimics by filling the stereochemical space that could be occupied by estrogenic compounds. This hypothesis has led to the rather wide off-label use of hormone supplements in order to help reverse the effects of aging and improve quality of life. Experts strongly believe that hormones—particularly dehydroepiandrosterone (DHEA)—should be a part of geriatric care, but nevertheless “countering aging effects” cannot be a basis for treatment.

    The Way Forward
    A significant number of epidemiological studies suggest a protective effect of several classes of nutrients against cognitive decline and risk of dementia, which are considered indicators of the aging process, including long-chain omega-3 polyunsaturated fatty acids, vitamins C and E, carotenoids, polyphenols and B vitamins, although some discordant data exist as well.

    On the basis of current evidence, indiscriminate use of antioxidant supplements in the general, well-nourished population cannot be justified and may increase risks. There is a clear need for a shift in attitude toward antioxidant supplements. Antioxidant supplements may need to be considered moved from over-the-counter to prescription medicine.

    Ultimately, there are significant trade-offs in the use of dietary supplementation for prevention and treatment of diseases associated with aging.


    Dilip Ghosh, PhD, FACN
    nutriConnect

    Dilip Ghosh, PhD, FACN, is director of nutriConnect, based in Sydney, Australia. He is also professionally involved with Soho Flordis International, the University of Western Sydney, Australia, and is an Honorary Ambassador with the Global Harmonization Initiative (GHI). Dr. Ghosh received his PhD in biomedical science from University of Calcutta, India. He has been involved in drug-development (both synthetic and natural) and functional food research and development both in academic and industry domains. Dr. Ghosh has published more than 60 papers in peer-reviewed journals, and he has authored two recent books, “Biotechnology in Functional Foods and Nutraceuticals,” and “Innovation in Healthy and Functional Foods,” under CRC Press. His next book, “Clinical Perspective of Functional Foods and Nutraceuticals” is in press. He can be reached at dilipghosh@nutriconnect.com.au; www.nutriconnect.com.au.
    Related Searches
    • Research
    • Omega-3
    • Nutraceuticals
    • Stress
    Related Knowledge Center
    • Dietary Supplements
    • Fatty Acids
    • Healthy Aging
    Suggested For You
    Marine Stewardship Council Calls for Increased Sustainability in Fish Oil Production Marine Stewardship Council Calls for Increased Sustainability in Fish Oil Production
    NSF International Launches Raised Without Antibiotics Certification NSF International Launches Raised Without Antibiotics Certification
    Food to Feed the Brain Food to Feed the Brain
    ‘Innovate or Die’ ‘Innovate or Die’
    Influencing the Microbiota-Gut-Brain Axis Through Diet Influencing the Microbiota-Gut-Brain Axis Through Diet
    Herbal Hopes for Brain Health Herbal Hopes for Brain Health
    Arla Launches Nutrilac WheyHi Arla Launches Nutrilac WheyHi
    Study Supports Stevia’s Naturality Study Supports Stevia’s Naturality
    Phytopharmaceutical:  An Emerging Platform Phytopharmaceutical: An Emerging Platform
    Fenugreek: An Herb To Watch Fenugreek: An Herb To Watch
    Study Predicts 40% of U.S. Adults Will Develop Type 2 Diabetes Study Predicts 40% of U.S. Adults Will Develop Type 2 Diabetes
    Up to 17% of the European Population Could Suffer Some Kind of Food Allergy Up to 17% of the European Population Could Suffer Some Kind of Food Allergy
    Preventing Cognitive Decline in Older People with Omega 3 Questioned Preventing Cognitive Decline in Older People with Omega 3 Questioned
    pTeroPure pTeroPure
    DHEA DHEA

    Related Content

    • Marine Nutraceuticals

      Marine Stewardship Council Calls for Increased Sustainability in Fish Oil Production

      Non-profit wants 20% of catch that goes into production of fish oil to come from MSC-certified fisheries by 2020.
      05.10.17

    • Breaking News | Certifications, Approvals & Patents | Testing

      NSF International Launches Raised Without Antibiotics Certification

      New protocol helps consumers identify animal products that do not contribute to growth of antibiotic-resistant bacteria.
      05.03.17

    • Cognitive Function | Fatty Acids | Herbs & Botanicals
      Food to Feed the Brain

      Food to Feed the Brain

      Nutrients influence cognition by acting on vital molecular systems or cellular processes.
      By Dilip Ghosh, PhD, FACN, nutriConnect 05.01.17


    • Cardiovascular Health | Healthcare Trends
      ‘Innovate or Die’

      ‘Innovate or Die’

      The cycle of waste needs to be broken.
      Sean Moloughney, Editor 04.03.17

    • Cognitive Function | Delivery & Dosage Technologies | Dietary Supplements | Digestive Health | Healthcare Trends | Healthy Aging | Immune Function | Inflammation | Probiotics & Prebiotics | Research
      Influencing the Microbiota-Gut-Brain Axis Through Diet

      Influencing the Microbiota-Gut-Brain Axis Through Diet

      Dietary components have serious implications for microbiota composition and health.
      Dilip Ghosh, PhD, FACN, nutriConnect 03.01.17

      Breaking News
      • Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
      • Jordan Process Receives Nutrasource ICAP Certification for CBD
      • FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Supplements
      • Nootropics and Adaptogens Respond to Demand for Mind and Mood Support
      • Sabinsa Honors 70th Anniversary of Diplomacy Between India and Japan
      View Breaking News >
      CURRENT ISSUE

      May 2022

      • Aging in Place: Lifestyle Supplements Science-Based Solutions
      • Getting an Edge in Esports: Meeting Health & Nutrition Needs
      • Nutraceuticals for Men: Muscle Health and Performance Nutrition

      Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
      You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

      • About Us
      • Privacy Policy
      • Terms And Conditions
      • Contact Us

      follow us

      Subscribe
      Nutraceuticals World

      Latest Breaking News From Nutraceuticals World

      Jordan Process Receives Nutrasource ICAP Certification for CBD
      FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Supplements
      Nootropics and Adaptogens Respond to Demand for Mind and Mood Support
      Coatings World

      Latest Breaking News From Coatings World

      AGM Secures Exclusive Distribution Agreement with Indian Partner Imkemex
      Microban Announced as Lead Sponsor of BCF Annual Conference and Dinner 2022
      DIC’s Indian Subsidiary Begins Construction of Coating Resins Production Facility
      Medical Product Outsourcing

      Latest Breaking News From Medical Product Outsourcing

      Innosuisse Awards $12.1 Million to Project for Futuristic Surgical Training
      XACT ACE OK'ed for Robotic Ablation Probe Insertion, Steering
      Nonin Medical Appoints Five New Board Members
      Contract Pharma

      Latest Breaking News From Contract Pharma

      Grand Opening of Kodiak Sciences’ Bioconjugation Facility
      Vertex Expands Cell and Gene Therapy Footprint
      AffyXell Expands Manufacturing Partnership with GenScript ProBio
      Beauty Packaging

      Latest Breaking News From Beauty Packaging

      Nu Skin Joins EcoBeautyScore Consortium
      Nails Inc Partners with Magnum, Expands Chocolate-Scented Nail Polish Line
      Aveda is Leaping Bunny Approved by Cruelty Free International
      Happi

      Latest Breaking News From Happi

      Barentz Develops Electronic Personal Care Product Guide
      P&G Temporarily Closes Downtown Cincinnati Office Due to Potential Security Concerns
      Eucerin Expands into US Sun Protection Market with New Sun Line
      Ink World

      Latest Breaking News From Ink World

      Nazdar Ink Technologies to Showcase Latest Ink Innovations at FESPA Global Print Expo 2022
      Epson Introduces First Direct-to-Fabric Printer for North America
      ProAmpac Facilities Secure Safety Awards 2022
      Label & Narrow Web

      Latest Breaking News From Label & Narrow Web

      In-Mold Decorating Association announces 2022 IMDA Awards Competition
      Essentra Packaging invests in Landa Nanographic press
      Nazdar to manufacture VFP electronic ink for US Market
      Nonwovens Industry

      Latest Breaking News From Nonwovens Industry

      'Right' Hygiene Conference to be Held in June
      Freudenberg to Present Battery Pack and Liquid Absorbers at Battery Show
      H&V Appoints Vice President and General Counsel
      Orthopedic Design & Technology

      Latest Breaking News From Orthopedic Design & Technology

      Envista To Acquire Osteogenics
      Exactech Earns Breakthrough Status for JointMedica's Polymotion Hip Resurfacing
      Orthotic Brace Suppliers Convicted in $6.5M Fraud Scheme
      Printed Electronics Now

      Latest Breaking News From Printed Electronics Now

      Emerson Earns Third Consecutive 2022 ENERGY STAR Partner of the Year Award
      First Solar to Sell Japan Project Development, O&M Platforms to PAG Real Assets
      Jabil Strengthens Additive Manufacturing Offerings

      Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

      AD BLOCKER DETECTED

      Our website is made possible by displaying online advertisements to our visitors.
      Please consider supporting us by disabling your ad blocker.


      FREE SUBSCRIPTION Already a subscriber? Login