• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    State of the Industry Series (Part 1): FDA Restructuring and FTC Activity

    State of the Industry Part 2: Supplement Access, Safety, and CBD

    State of the Industry Part 3: Communication, Education, and Trust

    State of the Industry Part 4: Advanced/Advancing Technologies and Research

    State of the Industry Part 5: Advocating Best Practices
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Glossary
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Women in Nutraceuticals Hires Executive Director Rebecca Takemoto

    FDA Issues Interim Response to Nammex’s Mushroom Labeling Petition

    MSM Linked to Improvements in Knee Pain

    Lion’s Mane Extract Linked to Better Cognitive Performance, Subjective Stress

    NutraShure Introduces SA3X as Exclusive US Supplier
    Exclusives
    Top Companies
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Lion’s Mane Extract Linked to Better Cognitive Performance, Subjective Stress

    NutraShure Introduces SA3X as Exclusive US Supplier

    Tocotrienol Supplementation May Aid Liver Function in Diabetes, MASL Patients

    Euromed Receives EcoVadis Platinum Medal for ESG Efforts

    State of the Industry Part 2: Supplement Access, Safety, and CBD
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    FDA Issues Interim Response to Nammex’s Mushroom Labeling Petition

    MSM Linked to Improvements in Knee Pain

    Lion’s Mane Extract Linked to Better Cognitive Performance, Subjective Stress

    NPA Lawsuit Claims New York Age Restriction on Supplements is Unconstitutional

    Kyowa Hakko Publishes First Report on Global Health, Sustainability Impact
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    MSM Linked to Improvements in Knee Pain

    Lion’s Mane Extract Linked to Better Cognitive Performance, Subjective Stress

    NutraShure Introduces SA3X as Exclusive US Supplier

    NPA Lawsuit Claims New York Age Restriction on Supplements is Unconstitutional

    Gencor’s PEA Ingredient Levagen+ May Offer Allergy Relief
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Sabinsa Corporation

    PhytoGaia Inc

    Applied Food Sciences, Inc.

    Xsto Solutions

    Botanic Healthcare LLC
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Sabinsa Corporation

    PhytoGaia Inc

    Applied Food Sciences, Inc.

    Xsto Solutions

    Botanic Healthcare LLC
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Top Companies
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Vitamin K2 Could Benefit Cardiovascular Health of Nicotine Users

    Research showed vitamin K2 to be an effective antioxidant capable of reducing oxidative stress and nicotine-induced vascular smooth muscle cell calcification.

    Vitamin K2 Could Benefit Cardiovascular Health of Nicotine Users
    07.27.21
    Smoking influences cardiovascular disease, resulting in accelerated atherosclerosis and vascular calcification. While the exact mechanisms whereby nicotine accelerates vascular disease is unknown, Cardiovascular Research published a study that investigated the effects of nicotine on initiation of vascular smooth muscle cell (VSMC) calcification.
     
    The study aimed to elucidate the underlying mechanisms of nicotine-induced VSMC calcification and examined vitamin K2 as a potential therapy. The study was completed with the support of NattoPharma, as partner within the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant INTRICARE.
     
    "In this study we show that smokers are at increased risk of cardiovascular events and that smoking impacts cardiovascular disease by increasing oxidative stress resulting in accelerated vascular calcification,” said Prof. Leon Schurgers, Professor of Biochemistry of Vascular Calcification and Vice-Chair of Biochemistry at the Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, and corresponding author to this paper. “We show that vitamin K2, next to its well-known function as a cofactor in the activation of vitamin K-dependent proteins, also is an effective antioxidant capable of reducing oxidative stress.”
     
    Researchers assessed vascular calcification of human carotid lesions of both smoking and non-smoking patients using ex vivo micro-computed-tomography (µCT)-scanning. Calcification was present more often in carotid plaques of smokers compared to non-smokers, confirming a higher atherosclerotic burden.
     
    The difference was particularly profound, according to researchers, “for microcalcifications, which was 17-fold higher in smokers compared to non-smokers. Using induced human primary VSMC in vitro, nicotine increased osteogenic gene expression (Runx2, Osx, BSP and OPN), extracellular vesicle (EV) secretion and subsequently increased calcification.”
     
    The pro-calcifying effects of nicotine were mediated by the free radical producing Ca2+-dependent Nox5. SiRNA knock-down of Nox5 inhibited nicotine-induced EV release and calcification. Additionally, the study showed that Nox5 expression was higher in carotid arteries of smokers and correlated with calcification levels in these vessels. Finally, pre-treatment of hVSMCs with vitamin K2 ameliorated nicotine-induced intracellular oxidative stress, EV secretion, and calcification.
     
    Researchers noted that nicotine is the primary agent in both cigarettes and e-cigarettes. These findings add to existing literature that vaping may not be a healthier choice when it comes to vascular health.
     
    Through the Horizon 2020 grants awarded, in which CARIM is coordinator and one of the beneficiaries, in partnership with NattoPharma, the company has hosted PhD students (ESRs) to teach them about the food and supplement industry and foster further understanding of the RDI values set by FDA/EFSA. Dr. Petsophonsakul, lead author on this paper, was one of those ESRs.
     
    “We have been working with Maastricht University for almost two decades validating the health benefits of vitamin K2, creating this category,” said Hogne Vik, Chief Medical Officer with NattoPharma, world leaders in K2 research and development and exclusive suppliers of MenaQ7 vitamin K2 as MK-7. “Our work, in addition to others’, is building the necessary body of evidence required to convince regulatory bodies how essential vitamin K2 is for the betterment of global human health. And this new study adds to our current pursued argument that vitamin K2 can have a tremendous impact as a cardiovascular therapy – not only in healthy populations, but in patient or unhealthy populations, like nicotine users.”
    Related Searches
    • Cardiovascular Health
    • Antioxidants
    • Research
    • Medical Nutrition
    Related Knowledge Center
    • Vitamins
    • Research
    • Medical Nutrition
    • Cardiovascular Health
    • Antioxidants
    Suggested For You
    Gnosis by Lesaffre Launches Private-Label Immune Support Supplement MenaQ7 Protect Gnosis by Lesaffre Launches Private-Label Immune Support Supplement MenaQ7 Protect
    Vitamin K2 Study: No Benefit in Vascular Calcification Found in Dialysis Patients Vitamin K2 Study: No Benefit in Vascular Calcification Found in Dialysis Patients
    Your K2VITAL® Guide: Choose the Right K2 to Power Your Next Innovation Your K2VITAL® Guide: Choose the Right K2 to Power Your Next Innovation
    New Study Highlights Importance of Bone Mineral Density as Proactive Target New Study Highlights Importance of Bone Mineral Density as Proactive Target
    Blue Helix Launches NAD+ Boosting Products, Debuts Clinical Research Program Blue Helix Launches NAD+ Boosting Products, Debuts Clinical Research Program
    Novozymes OneHealth to Showcase Psychobiotic, Postbiotic Ingredients Novozymes OneHealth to Showcase Psychobiotic, Postbiotic Ingredients
    Dyna-Tabs, LLC Dyna-Tabs, LLC
    Probiotix Health Launches New Heart Health Supplement CholBiome Probiotix Health Launches New Heart Health Supplement CholBiome
    Clinical Study to Commence on Migraines and Vitamin K2 Clinical Study to Commence on Migraines and Vitamin K2
    Gnosis By Lesaffre Announces Customer Experience Measures Gnosis By Lesaffre Announces Customer Experience Measures
    Reproductive Factors, Menopause Play Understated Role in Heart Health Risk Reproductive Factors, Menopause Play Understated Role in Heart Health Risk
    Kappa Bioscience to Showcase Synergies with Parent Company Balchem Kappa Bioscience to Showcase Synergies with Parent Company Balchem
    Novozymes OneHealth to Give Presentations on Spores, Vitamin K2, and Psychobiotics Novozymes OneHealth to Give Presentations on Spores, Vitamin K2, and Psychobiotics
    Moms Raise the Bar for Kids Supplements Moms Raise the Bar for Kids Supplements
    CRN Highlights CRN Highlights 'Supplement to Savings' Report for National Heart Month

    Related Breaking News

    • Contract Manufacturing | Dietary Supplements | Immune Function | Probiotics & Prebiotics | Vitamins
      Gnosis by Lesaffre Launches Private-Label Immune Support Supplement MenaQ7 Protect

      Gnosis by Lesaffre Launches Private-Label Immune Support Supplement MenaQ7 Protect

      Collaboration with Probiotical features vitamin K2 with probiotics and vitamin C in an orange-flavored stick pack.
      11.29.23

    • Breaking News | Cardiovascular Health | Medical Nutrition | Research | Research News | Vitamins
      Vitamin K2 Study: No Benefit in Vascular Calcification Found in Dialysis Patients

      Vitamin K2 Study: No Benefit in Vascular Calcification Found in Dialysis Patients

      The inconclusive findings suggested that kidney patients may need greater dosages of vitamin K2 in order to achieve cardioprotective benefits.
      10.19.23

    • Your K2VITAL® Guide: Choose the Right K2 to Power Your Next Innovation

      Your K2VITAL® Guide: Choose the Right K2 to Power Your Next Innovation

      ...


    • Bone & Joint Health | Breaking News | Healthy Aging | Medical Nutrition | Research News
      New Study Highlights Importance of Bone Mineral Density as Proactive Target

      New Study Highlights Importance of Bone Mineral Density as Proactive Target

      Proactive strategies to improve bone density should be an important concept in healthy aging product development, notes vitamin K2 supplier Gnosis by Lesaffre.
      10.10.23

    • Dietary Supplements | Healthy Aging | Herbs & Botanicals
      Blue Helix Launches NAD+ Boosting Products, Debuts Clinical Research Program

      Blue Helix Launches NAD+ Boosting Products, Debuts Clinical Research Program

      The newly-founded company will be pioneering research into the mechanisms behind boosting production of the coenzyme, and links to health benefits.
      10.10.23

    Loading, Please Wait..
    Breaking News
    • Women in Nutraceuticals Hires Executive Director Rebecca Takemoto
    • FDA Issues Interim Response to Nammex’s Mushroom Labeling Petition
    • MSM Linked to Improvements in Knee Pain
    • Lion’s Mane Extract Linked to Better Cognitive Performance, Subjective Stress
    • NutraShure Introduces SA3X as Exclusive US Supplier
    View Breaking News >
    CURRENT ISSUE

    December 2023

    • State of the Industry Series (Part 1): FDA Restructuring and FTC Activity
    • State of the Industry Part 2: Supplement Access, Safety, and CBD
    • State of the Industry Part 3: Communication, Education, and Trust
    • State of the Industry Part 4: Advanced/Advancing Technologies and Research
    • State of the Industry Part 5: Advocating Best Practices
    • State of the Industry Part 6: Business Trends and Innovation
    • Radicle Science Aims to Set New Trajectory for Healthcare with Modern Clinical Trial Model
    • How Can the Nutraceuticals Industry Empower More Women?
    • The Naturally Proud Network: Supporting Diversity, Equity, and Inclusion
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Women in Nutraceuticals Hires Executive Director Rebecca Takemoto
    FDA Issues Interim Response to Nammex’s Mushroom Labeling Petition
    MSM Linked to Improvements in Knee Pain
    Coatings World

    Latest Breaking News From Coatings World

    Orion S.A. Has Four Carbon Black Plants Awarded ISCC PLUS
    Peninsula Polymers Acquires New Distribution Center in Indiana
    PPG Completes COLORFUL COMMUNITIES Project in Shildon, UK
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Babson Diagnostics’ BetterWay Achieves Regulatory Milestone
    WhiteSwell Successfully Treats Acute Decompensated Heart Failure in Study
    Everly Health Releases At-Home Collection Kidney Health Test
    Contract Pharma

    Latest Breaking News From Contract Pharma

    FDA Approves Bio-Thera's Biosimilar Referencing Roche’s Avastin
    Full-Life Technologies to Build GMP Radiopharmaceuticals Mfg. Facility
    Innovent Biologics, Synaffix Expand ADC Licensing Deal
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    COSRX’s Latest TikTok Campaign Accumulates 3.2B Views on TikTok
    Christian Louboutin Taps Morgane Martini as Global Makeup Artist
    Shiseido Forms New Venture Fund
    Happi

    Latest Breaking News From Happi

    Estée Lauder Lead Scientist Dr. Nadine Pernodet To Lecture At SCC Science Meeting
    Topical Testosterone Formulation for Chest Hair Growth
    New York City Is Hub for Cosmetic Chemistry Next Week
    Ink World

    Latest Breaking News From Ink World

    Orion S.A. Now Has Four Carbon Black Plants Awarded ISCC PLUS
    BASF Commits to Scope 3.1 Emissions Targets
    Dantex and ACTEGA Partner on ECOLEAF
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Analyzing the Russian label market, Carter boosts brands and more
    FLAG’s December Lunch & Learn to feature Omet
    UPM Raflatac releases neuromarketing study findings
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Ginni Strikes Deal to Sell Spinning, Knitting Operations
    Campen Machinery Announces Patent Pending Status for Airlaid Trays
    Veocel Partners with Beauty and Feminine Care Brands in Asia Pacific
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Fujitsu, iSurgery Launch Bone Health Promotion Project in Japan
    Wenzel Spine Hires Dr. Robert Gordon as Executive Chairman
    Dr. Srikant Datar to Retire from Stryker's Board of Directors
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Intel CEO Pat Gelsinger to Cover AI During CES 2024 Keynote
    Ciena Invests in US Manufacturing with Flex
    Sitoo, SML Team Up to Enhance CX and Retail Operations

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login