• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    How Can the Nutraceuticals Industry Empower More Women?

    The Naturally Proud Network: Supporting Diversity, Equity, and Inclusion

    Radicle Science Aims to Set New Trajectory for Healthcare with Modern Clinical Trial Model

    Key Trends in Functional Foods for 2024

    New Cognitive Health Solutions Aim to Address Varied Consumer Needs
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Glossary
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Ahiflower Replaces Key Tissue DHA in Mice Comparably to Marine DHA

    Chromadex’s Niagen NR Tested in Phase 1 Parkinson's Study

    Alkemist Announces New Participants in its Transparency Program

    One Hemp Coalition Forms to Advocate for CBD Regulatory Standards

    Earthlight Whole Food Vitamin D Receives Food, Beverage Approval in Brazil
    Exclusives
    Top Companies
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Ahiflower Replaces Key Tissue DHA in Mice Comparably to Marine DHA

    One Hemp Coalition Forms to Advocate for CBD Regulatory Standards

    Earthlight Whole Food Vitamin D Receives Food, Beverage Approval in Brazil

    FDA’s Safety Review of NAC to Go Under Peer Review

    Gnosis by Lesaffre Launches Private-Label Immune Support Supplement MenaQ7 Protect
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Ahiflower Replaces Key Tissue DHA in Mice Comparably to Marine DHA

    Chromadex’s Niagen NR Tested in Phase 1 Parkinson's Study

    How Can the Nutraceuticals Industry Empower More Women?

    Alkemist Announces New Participants in its Transparency Program

    One Hemp Coalition Forms to Advocate for CBD Regulatory Standards
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    How Can the Nutraceuticals Industry Empower More Women?

    Pharmavite Acquires Women’s Health Brand Bonafide for $425 Million

    Kyowa Hakko Discussed Cognitive Health Supplements at Neuro Navigators Event

    Gnosis by Lesaffre Launches Private-Label Immune Support Supplement MenaQ7 Protect

    Beauty Brand Genaura to Launch Product Line Featuring Gencor’s Levagen+
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    PhytoGaia Inc

    PLT Health Solutions

    BGG World

    Sabinsa Corporation

    American FlexPack
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    PhytoGaia Inc

    PLT Health Solutions

    BGG World

    Sabinsa Corporation

    American FlexPack
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Top Companies
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Review Discusses Vitamin C’s Benefit in Metabolic Syndrome

    The compound’s anti-oxidative and anti-inflammatory properties have been well-catalogued in a vast body of human clinical trials.

    Review Discusses Vitamin C’s Benefit in Metabolic Syndrome
    The review sums up clinical substantiation for vitamin C's preventative and therapeutic roles in metabolic syndrome that have come about over the past two decades.
    07.31.20
    A review published in the International Journal of Medical Sciences summed up a vast body of human clinical trials suggesting that vitamin C plays an important role in the prevention and management of metabolic syndrome, a cluster of often concurrent conditions including elevations in blood pressure and serum glucose, high triglycerides, excess body fat around the waist, and abnormal cholesterol levels, heightening a person’s risk for developing a number of serious and potentially fatal non-communicable diseases, such as heart attack, stroke, type 2 diabetes, and cardiovascular disease.
     
    While the authors concluded that the mechanism of action has yet to be fully determined, they hypothesize that the anti-inflammatory and anti-oxidative properties of vitamin C likely play some role, and the significant reductions of metabolic syndrome induced in populations through better intakes of vitamin C in foods, beverages, and dietary supplements shows that it is important to maintain vitamin C concentration to reduce the risk, and potentially reverse, metabolic syndrome.
     
    Our current medical recommendations for addressing metabolic syndrome include improving dietary patterns that are high in the consumption of refined carbohydrates and saturated fats, as well as avoiding foods and beverages containing high sugar and fat content, and maintaining aerobic exercise. Where these measures fail, the next step is often drug therapies or bariatric surgery. However, there has been a growing interest in anti-oxidative and anti-inflamatory agents for their potential use in prevention and therapy for metabolic syndrome.
     
    Five animal studies that were reviewed, using rodents and rabbits, examined the effects of vitamin C alone as well as vitamin C within a cocktail of antioxidants. Each of the trials, which ranged from 4 weeks to 9 months, resulted in significant reductions to symptoms of obesity, hyperglycemia, hypertension, and levels of LDL cholesterol.
     
    The findings were categorized by those which evaluated impacts on MetS by vitamin C intake, vitamin C circulation, and vitamin C supplementation. The researchers then some up the body of evidence surrounding the potential mechanism of action for vitamin C in the management of MetS.
     
    Intake and Metabolic syndrome
     
    26 human clinical trials were included in the review, each of which directly evaluated the role that vitamin C had in mitigating or preventing the onset of metabolic syndrome symptoms, representing populations consisting of thousands of participants.
     
    Three large cross-sectional studies examined the direct association with metabolic syndrome, by the Korea National Health and Nutrition Examination Survey (KNHANES), which found that vitamin C intake was about 7% lower in the MetS group than the non-MetS group in a total of 22,671 adults. There was a pronounced decrease in waist circumference in individuals with high vitamin C intake, high physical activity, or both.. Vitamin C intake and physical activity combined also improved triglycerides, and both high physical activity and vitamin C intake were able to independently decrease the risk of MetS at similar rates.
     
    Another Korean study also identified a correlation between MetS, and lower vitamin C intake after adjusting for cofounding factors such as age and sex in a pool of 221 patients.
     
    A 2019 study provided an updated version of the evaluation of the association between 100% fruit juice consumption with risk factors for MetS. The study, conducted on over 10,000 participants, found that consumers of 100% fruit juice had higher intake of vitamin C compared to non-consumers, and, compared to non-consumers, had lower BMI, body weight, waist circumference, plasma glucose, and glycated hemoglobin. These fruit juice consumers experienced an overall decrease in overweight or obesity, raised waist circumference, and having MetS.
     
    Circulating Vitamin C Concentration
     
    Four cross-sectional studies involving participants in the National Health and Nutrition Examination Survey demonstrated that serum vitamin C concentration was associated with MetS outcomes, sourced from thousands of participants in adult and adolescent age groups. Additionally, it was found that vitamin C concentration decreased with increases in BMI and the number of components of MetS.
     
    This phenomenon was corroborated by another cross-sectional study recruiting 85 Brazilian adults, 200 Nigerian adults, and two other case-control studies which found that vitamin C concentration was additionally able to lower blood pressure.
     
    Two cross-sectional studies specifically on vitamin C concentration reported paradoxical results, however. They reported that among 46 participants diagnosed with MetS, no significant difference was observed in the plasma vitamin C concentration among individuals with and without MetS, nor were there any significant differences in other oxidative stress parameters, or antioxidant levels. The authors of these studies concluded that the discrepancy in results compared to other studies could have been due to the presence of other antioxidants besides vitamin C which could have counteracted the effects of vitamin C on oxidative stress.
     
    Supplementation

     
    A 2009 clinical trial conducted with 5,220 participants in France was the first to specifically examine vitamin C intake in the form of dietary supplements as opposed to other food and beverage sources. The participants were all free of MetS, and were followed for 7.5 years. While this first study found that there were no significant differences between supplementation and incident risk of MetS, participants who had higher measures of baseline vitamin C concentration had a lower MetS incident risk.
     
    Two randomized controlled trails in examined the effects of vitamin C supplementation alone, as well as in combination with endurance physical activity. The group taking vitamin C alone experienced lower tryglyceride levels compared to the placebo, and resulted in a decreased BMI compared to the placebo group. The additional benefit of reduced blood pressure was observed when vitamin C supplementation was combined with 30 minutes of endurance exercise daily.
     
    A 2019 trial found that a combination of zinc and vitamin C resulted in reductions of fasting blood glucose, tryglycerides, and systolic and diastolic blood pressure in a group of postmenopausal women. In the same year, another trial found that daily intake of orange juice resulted in higher concentrations of vitmaain C as well as improved MetS features, including decreased body weight, BMI, waist circumference, fat mass, visceral fat area, blood glucose, tryglycerides, and blood pressure. Only those who had a daily intake of orange juice also experienced lowered insulin and insulin resistance levels.
     
    “The current evidence shows that high vitamin C intake, concentration, and supplementation are beneficial in reversing MetS except for a few studies,” the authors concluded. Because many of the randomized controlled trials involved the intake of other antioxidants besides vitamin C, “it is hard to justify whether the beneficial effects in improving MetS abnormalities were contributed by vitamin C or other compounds that present in the combined therapy. However, it can be suggested that the supplementation of vitamin C in combination with other antioxidants or exercise may provide synergistic effects in the management of MetS and its associated conditions.”
     
    Oxidative stress, a hallmark of MetS, has been shown to have a number of causes, including diets high in fat and carbohydrates, as well as low physical activity, due to the state of overnutrition this causes. Overnutrition, and the resulting rise in fat content, causes enzymatic anti-oxidant processes to be inhibited. Another hallmark of MetS is chronic, low-grade inflammation, which is also experienced in people with obesity, but not MetS.
     
    “In short, oxidative stress and inflammation are two interrelated conditions that ccharacterie the pathophysiology of MetS and its related manifestations. The rise in inflammatory mediators could be responsible for the increase in reactive oxygen species, and vice versa,” The authors wrote.
    Related Searches
    • Dietary Supplements
    • Vitamins
    • Medical Nutrition
    • Inflammation
    Related Knowledge Center
    • Dietary Supplements
    • Weight Management/Weight Loss
    • Medical Nutrition
    • Diabetes & Blood Sugar Management
    • Inflammation
    • Cardiovascular Health
    • Antioxidants
    • Research
    • Functional Foods & Beverages
    Suggested For You
    Key Trends in Functional Foods for 2024 Key Trends in Functional Foods for 2024
    Eriomin Associated with Improved Microbiota in People with Prediabetes Eriomin Associated with Improved Microbiota in People with Prediabetes
    Microbiome Modulation: Emerging Probiotic Benefits Microbiome Modulation: Emerging Probiotic Benefits
    Nutrartis Launches Cardiosmile Plant Sterols in U.S. Nutrartis Launches Cardiosmile Plant Sterols in U.S.
    Physician-Formulated Solutions from 1MD Nutrition Target Major Health Concerns Physician-Formulated Solutions from 1MD Nutrition Target Major Health Concerns
    Probiotic Linked to Improvements in Metabolism Markers Probiotic Linked to Improvements in Metabolism Markers
    Cleveland Clinic Researchers Associate Common Sweetener with Heart Attack and Stroke Cleveland Clinic Researchers Associate Common Sweetener with Heart Attack and Stroke
    Tocotrienols May Have Protective Effect on Liver in NAFLD Patients Tocotrienols May Have Protective Effect on Liver in NAFLD Patients
    Epax Launches Omega-11 Cetoleic Acid Ingredient Epax Launches Omega-11 Cetoleic Acid Ingredient
    The Skinny on Weight Management in Our Transformational Year The Skinny on Weight Management in Our Transformational Year
    Weight Management: Supplements Find Their Place in a Bigger Picture Weight Management: Supplements Find Their Place in a Bigger Picture
    Formulating for Weight Loss Products Formulating for Weight Loss Products
    Fight or Flight? Prolonged Stress Takes A Toll on Public Health Fight or Flight? Prolonged Stress Takes A Toll on Public Health
    Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD
    New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance

    Related Features

    • Cognitive Function | Consumer Trends | Dairy-Based Ingredients | Delivery & Dosage Technologies | Diabetes & Blood Sugar Management | Digestive Health | Functional Foods & Beverages | Herbs & Botanicals | Minerals | Probiotics & Prebiotics | Weight Management/Weight Loss
      Key Trends in Functional Foods for 2024

      Key Trends in Functional Foods for 2024

      Young people in particular are hungry for health benefits from food. As nutrition ‘rules’ change and need-states evolve, new business opportunities emerge.
      By Julian Mellentin, New Nutrition Business 11.01.23

    • Antioxidants | Breaking News | Diabetes & Blood Sugar Management | Dietary Supplements | Digestive Health | Herbs & Botanicals | Research | Research News | Supplier News
      Eriomin Associated with Improved Microbiota in People with Prediabetes

      Eriomin Associated with Improved Microbiota in People with Prediabetes

      The blend of citrus flavonoids reduced growth of various bacteria associated with obesity, prediabetic factors, and digestive health issues.
      10.03.23

    • Microbiome Modulation: Emerging Probiotic Benefits

      Microbiome Modulation: Emerging Probiotic Benefits

      Next-generation probiotics are moving beyond digestion toward condition-specific health outcomes.
      By Mike Montemarano, Associate Editor 10.03.23


    • Breaking News | Cardiovascular Health | Dietary Supplements | Herbs & Botanicals | Products
      Nutrartis Launches Cardiosmile Plant Sterols in U.S.

      Nutrartis Launches Cardiosmile Plant Sterols in U.S.

      The stick packs were linked to significant reductions in LDL cholesterol and triglycerides in a placebo-controlled study.
      09.13.23

    • Cardiovascular Health | Contract Manufacturing | Dietary Supplements | Healthcare Trends | Probiotics & Prebiotics
      Physician-Formulated Solutions from 1MD Nutrition Target Major Health Concerns

      Physician-Formulated Solutions from 1MD Nutrition Target Major Health Concerns

      Ziv Haklili discusses the company’s mission to empower people to lead stronger, healthier lives.
      By Sheldon Baker, Baker Dillon Group 08.21.23

    Loading, Please Wait..
    Breaking News
    • Ahiflower Replaces Key Tissue DHA in Mice Comparably to Marine DHA
    • Chromadex’s Niagen NR Tested in Phase 1 Parkinson's Study
    • Alkemist Announces New Participants in its Transparency Program
    • One Hemp Coalition Forms to Advocate for CBD Regulatory Standards
    • Earthlight Whole Food Vitamin D Receives Food, Beverage Approval in Brazil
    View Breaking News >
    CURRENT ISSUE

    November 2023

    • Success Factors in Sports Nutrition
    • Key Trends in Functional Foods for 2024
    • New Cognitive Health Solutions Aim to Address Varied Consumer Needs
    • Why Women are Fleeing STEM Jobs, and How the Nutraceutical Industry Can WIN Them Back
    • Liposomal Delivery: The Future for Dietary Supplement Innovation
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Ahiflower Replaces Key Tissue DHA in Mice Comparably to Marine DHA
    Chromadex’s Niagen NR Tested in Phase 1 Parkinson's Study
    Alkemist Announces New Participants in its Transparency Program
    Coatings World

    Latest Breaking News From Coatings World

    PPG Earns Equality 100 Award in 2023 Corporate Equality Index
    Beckers Aiming for New Industry Standard for Sustainability
    Birla Carbon Celebrates 65th Anniversary of Cubatão Plant in Brazil
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    What You’re Reading in November
    Millstone Medical Outsourcing Moves Testing Services into Expanded Facility
    Nordson Medical Expands Easton, PA Operations
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Intas Pharmaceuticals Receives Another Warning Letter from FDA
    Ono Expands Investment in Ono Venture Fund to $200M
    Sirnaomics Names Francois Lebel Chief Medical Officer
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Mary Kay Expands Operations into Hungary
    Anti-Aging Products Market to Hit $60 Billion by 2030
    Wella Company Marks 3 Years of Success—& Aims to Expand
    Happi

    Latest Breaking News From Happi

    Beverly Hills MD Sells Over 7.5 Million Units of Its Dermal Repair Complex
    Mary Kay Expands to Hungary
    Itching: Is a Common Skin Bacterium Behind It?
    Ink World

    Latest Breaking News From Ink World

    Pacer Print Produces High Quality Labels with Epson SurePress L-6534VW UV
    BASF Expands Certification of Recyclability of Multi-layer Films Containing Polyamide
    Mark Andy Selects Duane Pekar as CEO
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Top stories from November
    Davis-Standard's headquarters attains ISO 14001 certification
    Abbott Label named AFFLINK preferred supplier
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Optima Packaging Group Awarded for its Digitalization Strategy
    What You’re Reading on Nonwovens-Industry.com
    ISSA Clean Advocacy Summit and Fly-In Set for April
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    ODT’s Most Read Articles in November
    Anika's Integrity Implant System Makes its O.R. Debut
    Study Shows How a Multimodal Feedback System Can Improve Laser Surgery
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Emerson Appoints Michael Tang as Chief Legal Officer
    Canatu Presents Film Heaters at DVN LiDAR
    Jabil Updates Fiscal 2024 Outlook

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login