• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    The Pet Health Boom: Supplement Growth Set to Build on Rapid Expansion

    (Re)Open for Business: China’s Strong Demand for Natural Products Spells Opportunity for U.S. Brands

    Review Finds No Causative Connection Between Dietary Supplements and Eating Disorders

    KA! Empathogenics: Creating Calm and Connectedness with Inspiration from Nature

    Moms Raise the Bar for Kids Supplements
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Glossary
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing

    BGG Receives Patent for Saw Palmetto ID Method

    Premium Label & Packaging Solutions Receives Safe Quality Food (SQF) Certification

    Inulinase Enzymes May Benefit Gut Symptoms of FODMAP Digestion

    Verdure Sciences’ Boswellia Ingredient Receives USP Verification
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing

    BGG Receives Patent for Saw Palmetto ID Method

    ‘Uniquely Unbound’: Releasing the Potential, and Genius, of Walnuts

    Inulinase Enzymes May Benefit Gut Symptoms of FODMAP Digestion

    Verdure Sciences’ Boswellia Ingredient Receives USP Verification
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing

    BGG Receives Patent for Saw Palmetto ID Method

    The Pet Health Boom: Supplement Growth Set to Build on Rapid Expansion

    ‘Uniquely Unbound’: Releasing the Potential, and Genius, of Walnuts

    Premium Label & Packaging Solutions Receives Safe Quality Food (SQF) Certification
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    ‘Uniquely Unbound’: Releasing the Potential, and Genius, of Walnuts

    Inulinase Enzymes May Benefit Gut Symptoms of FODMAP Digestion

    Gaming and Esports Health Concerns

    Bioiberica’s DAOgest Authorized as Novel Food ingredient in EU

    Review Finds No Causative Connection Between Dietary Supplements and Eating Disorders
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Verdure Sciences

    Bioenergy Life Science, Inc. (BLS)

    BGG Americas, Inc.

    Botanic Healthcare LLC

    Aiya America, Inc. (Aiya Matcha)
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Verdure Sciences

    Bioenergy Life Science, Inc. (BLS)

    BGG Americas, Inc.

    Botanic Healthcare LLC

    Aiya America, Inc. (Aiya Matcha)
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Research Highlights Danger of Vitamin B12 Deficiency

    Rice University scientists found B12 promotes survival in roundworms during infection by improving mitochondrial health.

    Research Highlights Danger of Vitamin B12 Deficiency
    03.15.19
    Using roundworms, one of Earth's simplest animals, Rice University bioscientists have found the first direct link between a diet with too little vitamin B12 and an increased risk of infection by two potentially deadly pathogens.
     
    Despite their simplicity, 1-millimeter-long nematodes called Caenorhabditis elegans (C. elegans) share an important limitation with humans: they cannot make B12 and must get all they need from their diet. In a study published today in PLOS Genetics, researchers from the lab of Rice biochemist and cancer researcher Natasha Kirienko describe how a B12-deficient diet harms C. elegans' health at a cellular level, reducing the worms' ability to metabolize branched-chain amino acids (BCAA). The research showed that the reduced ability to break down BCAAs led to a toxic buildup of partially metabolized BCAA byproducts that damaged mitochondrial health.
     
    Researchers studied the health of two populations of worms, one with a diet sufficient in B12 and another that got too little B12 from its diet. Like the second population of worms, at least 10% of U.S. adults get too little B12 in their diet, a risk that increases with age.
     
    "We used C. elegans to study the effect of diet on a host and found that one kind of food was able to dramatically increase resistance to multiple stressors—like heat and free radicals—as well as to pathogens," said Kirienko, assistant professor of biosciences and a CPRIT Scholar in Cancer Research at Rice.
     
    The lead scientist and co-author of the study, Kirienko said the B12 finding came as a surprise to her team, which first noticed the effect in experiments designed to investigate the mechanisms of pathogenesis of Pseudomonas aeruginosa (P. aeruginosa), a potentially deadly disease in both worms and humans that infects some 51,000 U.S. hospital patients each year, according to the Centers for Disease Control.
     
    Her lab, like thousands of others worldwide, uses C. elegans as a model organism to study the effects of disease, drugs, toxins and other processes that affect humans and animals. In many C. elegans research labs worms are fed Escherichia coli(E. coli), a common human gut bacteria that is itself a model organism.
     
    "We found that switching between E. coli strain OP50 and strain HT115 dramatically altered the worm's stress tolerance," Kirienko said. She said it took about two years of follow-up studies to isolate the biochemical mechanism of stress and pathogen resistance. Her research team included study lead co-author Alexey Revtovich and co-author Ryan Lee.
     
    "The key difference between the two diets is the ability of HT115 and OP50 to acquire B12 from the environment," said Revtovich, a research scientist. "We showed that HT115 is far more efficient at this, making about eight times as much of the protein that it needs to harvest B12 as compared to OP50."
     
    The researchers used numerous tests to confirm their results and rule out other possible mechanisms for the effect. They also found that C. elegans on an HT115 diet had the ability to resist infection by another deadly human pathogen, Enterococcus faecalis.
     
    Lee, a Rice undergraduate student, said the study highlights the need for C. elegans labs worldwide to pay attention to the possible differential impacts of diet on experimental outcomes.
     
    "Some labs use OP50 as their standard food, and others use HT115 or even another strain of E. coli," Lee said. "Our results show there are significant metabolic differences between these diets, and it's likely those differences could contribute to substantial uncertainty in research outcomes."
     
    Kirienko joined Rice's faculty in 2015 thanks to a recruitment grant from the Cancer Prevention and Research Institute of Texas (CPRIT), a state ballot initiative approved in 2007 to provide $3 billion to support cancer research statewide. To date, CPRIT has awarded $2.2 billion in grants to Texas researchers, institutions and organizations through its academic research, prevention, and product development research programs.
     
    "This work is related in the sense that it focuses on mitochondrial health," Kirienko said. "In this case, we are working to improve mitochondrial health to help fight infections. For CPRIT, we're trying to do the opposite. We want to damage mitochondria in cancer cells to kill them. So, actually, now that we know this is important, it gives us another potential target in cancer cells."
    Related Searches
    • Free Radicals
    • Vitamin
    • Amino Acids
    • Health
    Related Knowledge Center
    • Research
    • Immune Function
    • Vitamins
    Suggested For You
    ExcelVite Sdn. Bhd. ExcelVite Sdn. Bhd.
    Vitamin D May Protect Obese Children from Asthma Symptoms Associated with Pollution Vitamin D May Protect Obese Children from Asthma Symptoms Associated with Pollution
    AFS Innovative, Functional Ingredients AFS Innovative, Functional Ingredients
    Eating Organic Can Reduce Pesticide Levels in Humans Eating Organic Can Reduce Pesticide Levels in Humans
    Nano-Encapsulation Technology Could Enhance Absorption of Omega-3 DHA Nano-Encapsulation Technology Could Enhance Absorption of Omega-3 DHA
    Nestlé Acquires Technology to Address Iron Deficiency Nestlé Acquires Technology to Address Iron Deficiency
    Non-GMO Project Renews Valensa International’s Parry Organic Spirulina, Organic Chlorella Non-GMO Project Renews Valensa International’s Parry Organic Spirulina, Organic Chlorella
    Vitamin D Named the UK Vitamin D Named the UK's Top Single Vitamin Supplement
    Not All Lycopene Supplements Contain What They Claim, ConsumerLab Tests Reveal Not All Lycopene Supplements Contain What They Claim, ConsumerLab Tests Reveal
    Large Meta-Analysis Backs Benefits of Probiotic for Gut Health Large Meta-Analysis Backs Benefits of Probiotic for Gut Health
    Silk Launches Non-Dairy Oatmilk Silk Launches Non-Dairy Oatmilk
    More Consumers Focused on Origin & Quality of Food More Consumers Focused on Origin & Quality of Food
    Vitamins & Minerals: Traditions in Preventive Health Vitamins & Minerals: Traditions in Preventive Health
    Findings Suggest Personalized Nutrition is Disrupting Cancer Findings Suggest Personalized Nutrition is Disrupting Cancer
    ConsumerLab Testing Compares Fish Oil Supplements to Prescription Fish Oil ConsumerLab Testing Compares Fish Oil Supplements to Prescription Fish Oil

    Related Buyers Guide Companies

    • ExcelVite Sdn. Bhd.

      ExcelVite Sdn. Bhd.

      ...
      Choymun Lai, Marketing Executive 11.01.22

    • Breaking News | Infant & Children's Health | Research | Research News | Vitamins
      Vitamin D May Protect Obese Children from Asthma Symptoms Associated with Pollution

      Vitamin D May Protect Obese Children from Asthma Symptoms Associated with Pollution

      Over 6 million U.S. children have the immune-mediated lung condition.
      03.15.19

    • AFS Innovative, Functional Ingredients

      AFS Innovative, Functional Ingredients

      ...


    • Breaking News | Cancer Risk | Cognitive Function | Infant & Children's Health | Natural/Organic | Regulations | Research | Research News
      Eating Organic Can Reduce Pesticide Levels in Humans

      Eating Organic Can Reduce Pesticide Levels in Humans

      After just six days of eating organic researchers found pesticides—which are linked to numerous health issues—declined by 60.5% in participants.

    • Breaking News | Delivery & Dosage Technologies | Infant & Children's Health | Omega-3s | Research News | Women's Health
      Nano-Encapsulation Technology Could Enhance Absorption of Omega-3 DHA

      Nano-Encapsulation Technology Could Enhance Absorption of Omega-3 DHA

      Mouse study aimed to address delivery and absorption issues of DHA that affect potency and efficacy.
      02.01.19

    Loading, Please Wait..
    Trending
    • Soviets Took Probiotics To The Next Level
    Breaking News
    • Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing
    • BGG Receives Patent for Saw Palmetto ID Method
    • Premium Label & Packaging Solutions Receives Safe Quality Food (SQF) Certification
    • Inulinase Enzymes May Benefit Gut Symptoms of FODMAP Digestion
    • Verdure Sciences’ Boswellia Ingredient Receives USP Verification
    View Breaking News >
    CURRENT ISSUE

    May 2023

    • Cellular Aging and Longevity: Ingredients for a New Age of Health
    • Addressing the Plastic-Packaging Problem: Getting to Zero-Waste with Zero Compromise
    • Moms Raise the Bar for Kids Supplements
    • Building on Steps to Improve Children’s Health Around the World
    • FDA Remains Focused on Modernizing DSHEA
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing
    BGG Receives Patent for Saw Palmetto ID Method
    Premium Label & Packaging Solutions Receives Safe Quality Food (SQF) Certification
    Coatings World

    Latest Breaking News From Coatings World

    Sherwin-Williams Leads Global Paints Brands in Value: Brand Finance
    Arkema Partnering with Habitat for Humanity Philadelphia
    Rhino Shield’s Ceramic Elastomeric Coatings has Best in Class Permeability
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    CareDx, Miromatrix Collaborate on Bioengineered Organs Research
    Capitainer Releases to Market its Fully Automated Sample Handler
    Titan Medical Licenses Most IP to Intuitive; CEO Steps Down
    Contract Pharma

    Latest Breaking News From Contract Pharma

    AVROBIO Sells Cystinosis Gene Therapy for $87.5 Million
    Meiji Seika Pharma, Adcock Ingram Pharma Complete Construction of New Manufacturing Facility
    JSR Life Sciences Consolidates KBI Biopharma and Selexis SA
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Unilever Uses AI for Product Development
    Beautycounter Names New Interim CEO
    Shaz & Kiks Available at Sephora
    Happi

    Latest Breaking News From Happi

    Sally Hansen Teams Up with GLAAD for Pride Month Collection
    Garnier Introduces Limited Edition Micellar Cleansing Water Duo for Pride Month
    Covergirl Introduces Clean Fresh Yummy Gloss Collection
    Ink World

    Latest Breaking News From Ink World

    Arkema Partners with Habitat for Humanity Philadelphia
    HP Inc. Reports Fiscal 2023 Second Quarter Results
    Kodak Acquires Graphic Systems Services Inc.
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    ACTEGA teams with Makro Labelling to advance Signite technology
    Constantia Flexibles and SB Packagings commence joint venture
    Inland donates new VersaStudio printer to local high school
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Mann+Hummel Names President Air Filtration Americas
    KNH Launches Eco-Friendly Menstrual Pads
    Niine Introduces India's First PLA-Based Sanitary Pads
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Enrollment Completed in Anika Therapeutics' Hyalofast Study
    Exactech Releases Next-Gen GPS Shoulder
    Data Shows Favorable Survivorship of MISHA Knee System & Reduction of Arthroplasty Risk in Patients
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Vitesco Technologies, onsemi Sign SiC Long-Term Supply Agreement
    Ambiq Receives 2023 Bronze Stevie Award
    onsemi Presents Path to Accelerate Revenue Growth

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login