• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains

    Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality

    Nutrition and Flavor: Formulating for Modern Product Preferences

    What Do Consumers Know About the Gut Microbiome?

    How Will the European Green Deal Impact Dietary Supplements?
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients

    IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Fact or Myth: Antioxidants Negatively Impact Iron Absorption

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Fact or Myth: Antioxidants Negatively Impact Iron Absorption

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    Caffeine-Free Energy Supplement Linked to Alertness, Fatigue Benefits

    Monk Fruit Sweetener May Have Prebiotic Activity, Study Finds

    People with Low-Fiber Diets Benefit the Most from Fiber Supplements, Study Finds

    Gut Microbiome May Be Part of Link Between Red Meat and Heart Disease Risk
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    JRS Pharma

    Atlantia Clinical Trials

    KLK OLEO

    Botanic Healthcare LLC

    Sabinsa Corporation
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    JRS Pharma

    Atlantia Clinical Trials

    KLK OLEO

    Botanic Healthcare LLC

    Sabinsa Corporation
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Delta-Tocotrienol Combined with Standard Therapy May Increase Survival in Ovarian Cancer Patients

    Anti-angiogenic activity of both compounds suspected as possible mechanism of action.

    Related CONTENT
    • Fiber Revisited: Closing the Gap
    • The Magical Mystery Tour Also Known as Cannabis Sativa
    • Trend Spotlight for 2019
    • Study Finds Mixture of Probiotic Strains and Lactoferrin Reduces Common Cause of Vaginal Discomfort
    • Fourteen Sami-Sabinsa Group Staff Members Now PCQI Certified
    01.28.19
    A recent study conducted at Denmark’s Vejle Hospital, published in Pharmacological Research, provided evidence of delta-tocotrienol’s benefits for cancer patients. Results of the open-label trial suggested that American River Nutrition-manufactured delta-tocotrienol in combination with bevacizumab had additive effects in chemotherapy refractory ovarian cancer, possibly conferred by the anti-angiogenic activity of both compounds. This is the first-ever clinical trial using tocotrienols in ovarian cancer patients, according to American River.
     
    In the study of 23 advanced-stage ovarian cancer patients, tocotrienol was administered at a dosage of 300 mg three times a day, with bevacizumab given to patients at 10 mg/kg intravenously every three weeks. Patient disease stabilization was high at 70%, with increased survival, which approximately doubled.
     
    Background
    Ovarian cancer is the fifth most common cause of cancer death in women in the U.S. According to the American Cancer Society, approximately 22,240 women in the U.S. received a new ovarian cancer diagnosis, while approximately 14,070 people died of the disease in 2018. Since ovarian cancer is usually not diagnosed until it is more advanced, the 5-year survival rate is only 47%. Patients with advanced-stage ovarian cancer often have a recurrence of the disease after primary treatment, and despite second and third line treatments, these patients eventually become chemotherapy-resistant with few therapeutic options. The goal at this stage is to improve the quality and duration of life with as few side effects as possible.
     
    In 2018, the FDA approved bevacizumab (Avastin), an anti-angiogenic agent, for frontline treatment of ovarian cancer after surgery, based on its ability to reduce disease progression by 38% in a double-blind, placebo-controlled, multicenter study. In Europe, the drug has been used for first-line and recurrent ovarian cancer treatment for much longer, since 2011, and shows similar promising results.
     
    Similar to bevacizumab, tocotrienols, isomers of the vitamin E family, have anti-angiogenic properties that are thought to contribute to the anti-neoplastic effect. Previous in vitro and in vivo studies, including a clinical trial in patients with pancreatic cancer, showed that delta-tocotrienol was especially active against malignancies, compared to other vitamin E isoforms.
     
    Study Details
    The Danish study, led by Dr. Anders Jakobsen at Vejle Hospital, aimed to identify the potential additive effects of bevacizumab and delta-tocotrienol by observing the stabilization and control of disease, progression-free survival (PFS), and overall survival (OS). Although the target level of 75% disease control at six months was not reached, the observed disease control of 50% at six months was high compared to only 25% of disease control when using bevacizumab as a single agent in another study conducted by the same researchers. Even more compelling is the result of a high overall disease control of 70% with a combination of bevacizumab and delta-tocotrienol.
     
    Compared to a typically reported median PFS of 2-4 months and median OS of 5-7 months, combined treatment of bevacizumab and delta-tocotrienol nearly doubled survival, allowing patients to reach a median PFS of 6.9 months and a median OS of 10.9 months. Notably, 25% of the patients were alive after 24 months.
     
    The study treatment was shown to have low toxicity, with only three patients discontinuing their medications due to well-known side effects of bevacizumab therapy. Further, quality of life was stable.
     
    The authors noted that “the present study indicates that the combination of bevacizumab and delta-tocotrienol is effective in multiresistant ovarian cancer.” They also mentioned that, “bevacizumab is used in a spectrum of different tumors and an additional effect by an atoxic drug holds high priority.”
     
    Commenting on the research, Dr. Barrie Tan, president of American River Nutrition said that “as one of the most deadly cancers in women, ovarian cancer needs further attention, and I applaud Dr. Jakobsen and his group for their novel approach in finding alternative treatment options for these patients. The fact that a simple vitamin such as tocotrienol in combination with standard therapy could prolong a woman’s life and improve its quality under these severe circumstances is nothing short of astonishing.”
    Related Searches
    • Vitamin
    • tocotrienol
    • Cancer
    • Research
    Related Knowledge Center
    • Women's Health
    • Cancer Risk
    • Vitamins
    Suggested For You
    Fiber Revisited: Closing the Gap Fiber Revisited: Closing the Gap
    The Magical Mystery Tour Also Known as Cannabis Sativa The Magical Mystery Tour Also Known as Cannabis Sativa
    Trend Spotlight for 2019 Trend Spotlight for 2019
    Study Finds Mixture of Probiotic Strains and Lactoferrin Reduces Common Cause of Vaginal Discomfort Study Finds Mixture of Probiotic Strains and Lactoferrin Reduces Common Cause of Vaginal Discomfort
    Fourteen Sami-Sabinsa Group Staff Members Now PCQI Certified Fourteen Sami-Sabinsa Group Staff Members Now PCQI Certified
    Study Finds Sensoril Ashwagandha Improves Strength Training Adaptations & Recovery Study Finds Sensoril Ashwagandha Improves Strength Training Adaptations & Recovery
    Sabinsa’s Nigellin Black Cumin Seed Extract Identified as Immunomodulator of Asthma Inflammation Sabinsa’s Nigellin Black Cumin Seed Extract Identified as Immunomodulator of Asthma Inflammation
    DuPont Research Shows Increase in Plant-Based Eating DuPont Research Shows Increase in Plant-Based Eating
    Frutarom Health Targets Sport Nutrition with Activeberry Performance Ingredient Frutarom Health Targets Sport Nutrition with Activeberry Performance Ingredient
    Immune Health: Building a Foundation of Wellness Immune Health: Building a Foundation of Wellness
    JAMA Study Uncovers Unapproved Ingredients in Products Marketed as Dietary Supplements JAMA Study Uncovers Unapproved Ingredients in Products Marketed as Dietary Supplements
    Research Examines Sabinsa’s Curcumin C3 Complex + BioPerine with Diabetic Subjects Research Examines Sabinsa’s Curcumin C3 Complex + BioPerine with Diabetic Subjects
    Potential Role of Microbe-Gut-Brain Axis on Mood Potential Role of Microbe-Gut-Brain Axis on Mood
    Harvard Researcher Questions Probiotic Benefits Harvard Researcher Questions Probiotic Benefits
    Probiotics May Help Reduce Antibiotic Use in Children Probiotics May Help Reduce Antibiotic Use in Children

    Related Features

    • Delivery & Dosage Technologies | Dietary Supplements | Digestive Health | Fiber & Carbohydrates | Functional Foods & Beverages | Herbs & Botanicals | Probiotics & Prebiotics | Regulations | Sweeteners | Weight Management/Weight Loss
      Fiber Revisited: Closing the Gap

      Fiber Revisited: Closing the Gap

      Since FDA’s redefinition of fiber, innovation in healthy and natural foods, supplements, and beverages is ready for a renaissance.
      By Lisa Schofield, Contributing Writer 01.03.19

    • Dietary Supplements | Herbs & Botanicals | Quality & Safety | Regulations
      The Magical Mystery Tour Also Known as Cannabis Sativa

      The Magical Mystery Tour Also Known as Cannabis Sativa

      What’s in the new Farm Bill and what does it mean for hemp and CBD?
      By Todd Harrison & Meryl Nolan, Venable 01.03.19

    • Consumer Trends | Digestive Health | Herbs & Botanicals | Immune Function | Quality & Safety | Regulations
      Trend Spotlight for 2019

      Trend Spotlight for 2019

      As companies embark on a new year, here’s a handful of trends and themes to consider.
      By Sean Moloughney, Editor 01.03.19


    • Breaking News | Probiotics & Prebiotics | Research | Research News | Sexual & Reproductive Health | Women's Health

      Study Finds Mixture of Probiotic Strains and Lactoferrin Reduces Common Cause of Vaginal Discomfort

      Clinical trial using DuPont Nutrition & Health probiotic strains shows Lactobacillus strains and lactoferrin prevents recurrent bacterial vaginosis.
      12.28.18

    • Breaking News | Certifications, Approvals & Patents | Quality & Safety | Regulations | World Markets

      Fourteen Sami-Sabinsa Group Staff Members Now PCQI Certified

      A total of 14 staff members are specifically trained in implementing the 21 CFR part 117 regulations, covering all of the company’s manufacturing facilities.
      12.17.18

    Loading, Please Wait..
    Trending
    • Study Examines Vitamin K2 Content In Cheese
    • Chenland Nutritionals Self-Affirms GRAS For Cumin UP60 Ingredient
    • Pycnogenol Evidenced To Have Skin Benefits In Dermatology Study
    • ADM And Benson Hill Partner To Scale High Protein Soy For U.S. Market
    Breaking News
    • Charlotte’s Web Sports Product Line to Undergo NSF Certification Process
    • ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    • Tazo Transitions to Regenerative Organic Agriculture
    • Protein Ingredient Formulated for Chronic Kidney Disease Patients
    • IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    View Breaking News >
    CURRENT ISSUE

    July/August 2022

    • A Growing Herbal Products Market Still Faces Formidable Threats, Challenges
    • Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality
    • Nutrition and Flavor: Formulating for Modern Product Preferences
    • Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains
    • How Will the European Green Deal Impact Dietary Supplements?
    • What Do Consumers Know About the Gut Microbiome?
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process
    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    Tazo Transitions to Regenerative Organic Agriculture
    Coatings World

    Latest Breaking News From Coatings World

    What are you Reading this Week?
    SONGWON Industrial Group Reports Strong Q2 Financial Results
    PPG Completes COLORFUL COMMUNITIES Project for Boys & Girls Clubs of Greater Houston
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    MPO's Most-Read Stories This Week—Aug. 13
    'Graft-on-a-Chip' Built to Improve Vascular Graft Success
    Abbott Invests €440 in New Irish Facility
    Contract Pharma

    Latest Breaking News From Contract Pharma

    AskBio Appoints Clinical Ops Executives
    SpectrumX Partners With UK Contract Manufacturer
    GL Chemtec Partners with Edgewater Capital to Accelerate Growth
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Arkay Chairman Emeritus Howard Kaneff Has Died
    Nutricosmetics Market to Hit $13.7 Billion by 2030
    Estée Lauder Pledges 100% Electric Fleet of Vehicles by 2030
    Happi

    Latest Breaking News From Happi

    Consumers are Clamoring for Vintage Glam: Spate
    Kayali’s Lovefest Fragrance, Newell’s New Candle and HydraFacial’s Record Financial Results
    Self Care Trumps Home Care Post-Covid
    Ink World

    Latest Breaking News From Ink World

    Weekly Recap: Printing Ink Primer, Zeller+Gmelin Lead This Week’s News Stories
    Heidelberg Enjoys Successful Start to 2022-23 Fiscal Year
    Mimaki Announces New LATAM Website
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Esko, Constantia Flexibles announce acquisitions and more
    Hybrid Software joins The Flexo Xperience Center
    Flexo Wash LLC and Mike Potter celebrate 20 years
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Weekly Recap: Essity Switches to Recyclable Packs for Feminine Pads, FTC Sues PPE Maker on False Origin Claims & More
    Focke & Co. to Host Destination: Your Hygiene Hub on August 31
    Exports Dominate Chinese Trade of Tissues, Hygiene Products and Wipes
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    ODT's Most-Read Stories This Week—Aug. 13
    Dental 3D Printing Market is Expanding 20% Annually
    Study Results Released for Abbott's Concussion Blood Test
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Weekly Recap: ALTANA, Universal Display and Emerson Top This Week’s Stories
    eMagin Corporation Announces 2Q 2022 Results
    Zebra Technologies’ Emission Reduction Targets Validated by SBTi

    Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login