• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Supporting Musculoskeletal Health: Tending to Muscles, Joints, and Bones

    2023 Contract Manufacturing Survey

    Dosage and Delivery Innovations Help Manufacturers Meet Common Challenges

    A Paradigm Shift for Antioxidants?

    Manufacturing Dietary Supplements in Economic Uncertainty
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Glossary
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    NPA: ‘Major Victory’ in Colorado After Amendment to Eating Disorder Bill

    GOOD Meat Receives FDA Go-Ahead for Cultured Meat

    IFF Achieves Industrial-Scale Production of Anaerobic Probiotic Strain

    Jones Healthcare Group Primed to Help Nutraceutical Brands Comply with New Packaging Rules

    Nordic Naturals Debuts Probiotic Line in More Than 375 Sprouts Farmer’s Markets
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Harmonizing the EU's Upper Limits For Micronutrients

    GOOD Meat Receives FDA Go-Ahead for Cultured Meat

    IFF Achieves Industrial-Scale Production of Anaerobic Probiotic Strain

    Nordic Naturals Debuts Probiotic Line in More Than 375 Sprouts Farmer’s Markets

    DolCas Biotech's Curcugen Featured in Beauty-From-Within Supplement
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    NPA: ‘Major Victory’ in Colorado After Amendment to Eating Disorder Bill

    Harmonizing the EU's Upper Limits For Micronutrients

    GOOD Meat Receives FDA Go-Ahead for Cultured Meat

    IFF Achieves Industrial-Scale Production of Anaerobic Probiotic Strain

    Jones Healthcare Group Primed to Help Nutraceutical Brands Comply with New Packaging Rules
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    NPA: ‘Major Victory’ in Colorado After Amendment to Eating Disorder Bill

    Nordic Naturals Debuts Probiotic Line in More Than 375 Sprouts Farmer’s Markets

    DolCas Biotech's Curcugen Featured in Beauty-From-Within Supplement

    NOW Tests Bromelain Supplements Purchased on Amazon

    Podcast: Erin Stokes, ND, on Natural Health Strategies and the Role for Dietary Supplements
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    BGG Americas, Inc.

    KLK OLEO

    PhytoGaia Inc

    Xsto Solutions

    American FlexPack
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    BGG Americas, Inc.

    KLK OLEO

    PhytoGaia Inc

    Xsto Solutions

    American FlexPack
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Researchers Uncover Key Mechanisms of Inflammation, Cancer and Aging

    Telomeres play key roles in a number of health conditions.

    02.27.17
    A team of University of Pittsburgh researchers uncovered new details about the biology of telomeres, “caps” of DNA that protect the tips of chromosomes and play key roles in a number of health conditions, including cancer, inflammation and aging. The new findings were published in the journal Nature Structural and Molecular Biology.
     
    Telomeres, composed of repeated sequences of DNA, are shortened every time a cell divides and therefore become smaller as a person ages. When they become too short, telomeres send a signal to the cell to stop dividing permanently, which impairs the ability of tissues to regenerate and contributes to many aging-related diseases, explained lead study author Patricia Opresko, PhD, associate professor of Environmental and Occupational Health at Pitt, and member of the University of Pittsburgh Cancer Institute Molecular and Cellular Cancer Biology program and Carnegie Mellon University Center for Nucleic Acids Science and Technology.
     
    In contrast, in most cancer cells, levels of the enzyme telomerase, which lengthens telomeres, are elevated, allowing them to divide indefinitely.
     
    “The new information will be useful in designing new therapies to preserve telomeres in healthy cells and ultimately help combat the effects of inflammation and aging. On the flip side, we hope to develop mechanisms to selectively deplete telomeres in cancer cells to stop them from dividing,” said Dr. Opresko.
     
    A number of studies have shown that oxidative stress—a condition where damaging molecules known as free radicals build up inside cell—accelerates telomere shortening. Free radicals can damage not only the DNA that make up telomeres, but also the DNA building blocks used to extend them.
     
    Oxidative stress is known to play a role in many health conditions, including inflammation and cancer. Damage from free radicals, which can be generated by inflammation in the body as well as environmental factors, is thought to build up throughout the aging process.
     
    The goal of the study was to determine what happens to telomeres when they are damaged by oxidative stress. The researchers suspected that oxidative damage would render telomerase unable to do its job.
     
    “Much to our surprise, telomerase could lengthen telomeres with oxidative damage,” Dr. Opresko said. “In fact, the damage seems to promote telomere lengthening.”
     
    Next, the team looked to see what would happen if the building blocks used to make up telomeres were instead subjected to oxidative damage. They found that telomerase was able to add a damaged DNA precursor molecule to the end of the telomere, but was then unable to add additional DNA molecules.
     
    The new results suggest that the mechanism by which oxidative stress accelerates telomere shortening is by damaging the DNA precursor molecules, not the telomere itself. “We also found that oxidation of the DNA building blocks is a new way to inhibit telomerase activity, which is important because it could potentially be used to treat cancer.”
     
    Dr. Opresko and her team are now beginning to further explore the consequences of oxidative stress on telomeres, using a novel photosensitizer, developed by Marcel Bruchez at Carnegie Mellon University that produces oxidative damage selectively in telomeres. “Using this exciting new technology, we’ll be able to learn a lot about what happens to telomeres when they are damaged, and how that damage is processed,” she said.
     
    Funding for the published research was provided by National Institutes of Health (NIH) grants R01ES022944, R21AG045545, R21ES025606, 1DP2GM105453 and CA148629; American Cancer Society grant RSG-12-066-01-DMC; and the Abraham A. Mitchell Distinguished Investigator fund. In addition, the research used the UPCI’s Cell and Tissue Imaging Facility and Cytometry Facility that are supported in part by NIH grant P30CA047904.
    Related Searches
    • Inflammation
    • Cancer
    • Stress
    • Research
    Related Knowledge Center
    • Inflammation
    • Healthy Aging
    • Cancer Risk
    Suggested For You
    Manufacturing Dietary Supplements in Economic Uncertainty Manufacturing Dietary Supplements in Economic Uncertainty
    Blue California: Delivering Sustainable, Evidence-Based Solutions for a Healthy Mind and Body Blue California: Delivering Sustainable, Evidence-Based Solutions for a Healthy Mind and Body
    Top Health Benefits of Glutathione, the Master Antioxidant Top Health Benefits of Glutathione, the Master Antioxidant
    Ergothioneine Study Reveals Signs of Possible Healthy Aging Benefit Ergothioneine Study Reveals Signs of Possible Healthy Aging Benefit
    The Immunity Imperative The Immunity Imperative
    Most Supplement Users Aware of Gut Microbiome, But Understanding Limited  Most Supplement Users Aware of Gut Microbiome, But Understanding Limited
    Aging Ain’t Easy Aging Ain’t Easy
    Building Foundations for Healthy Living Building Foundations for Healthy Living
    Vitamin D Shows Promise in Reducing Cancer in Older Women Vitamin D Shows Promise in Reducing Cancer in Older Women
    Weighty Matters: Implications for Repeal of the Affordable Care Act Weighty Matters: Implications for Repeal of the Affordable Care Act
    Prebiotic Shown to Improve Appetite Control in Obese Children Prebiotic Shown to Improve Appetite Control in Obese Children
    KOHJIN Rebrands Glutathione as OPITAC KOHJIN Rebrands Glutathione as OPITAC
    Resources & Standards:  An Oven is Not a Cake Recipe Resources & Standards: An Oven is Not a Cake Recipe
    Go for the Gold Go for the Gold
    Antioxidants Outlook:  Expanding Options for Aging Well Antioxidants Outlook: Expanding Options for Aging Well

    Related Features

    • Contract Manufacturing | Delivery & Dosage Technologies | Dietary Supplements | Quality & Safety | World Markets
      Manufacturing Dietary Supplements in Economic Uncertainty

      Manufacturing Dietary Supplements in Economic Uncertainty

      Cost pressures are challenging brands to meet varying consumer needs.
      By Sean Moloughney, Editor 02.28.23

    • Antioxidants | Dietary Supplements | Healthy Aging | Supplier Insights
      Blue California: Delivering Sustainable, Evidence-Based Solutions for a Healthy Mind and Body

      Blue California: Delivering Sustainable, Evidence-Based Solutions for a Healthy Mind and Body

      Company’s expanded portfolio includes ingredients produced via fermentation and enzymatic conversion to target key areas of health.

    • Antioxidants | Healthy Aging | Immune Function | Inflammation | Proteins, Peptides, Amino Acids
      Top Health Benefits of Glutathione, the Master Antioxidant

      Top Health Benefits of Glutathione, the Master Antioxidant

      GSH stops free radicals from damaging cells while also assisting other antioxidants along the way.
      By Nayan Patel, PharmD, Author of The Glutathione Revolution 03.02.22


    • Breaking News | Cosmeceuticals / Nutricosmetics | Dietary Supplements | Healthy Aging | Proteins, Peptides, Amino Acids | Research | Research News
      Ergothioneine Study Reveals Signs of Possible Healthy Aging Benefit

      Ergothioneine Study Reveals Signs of Possible Healthy Aging Benefit

      This amino acid helps preserve telomere length, which shortens with aging and oxidative stress.
      12.11.20

    • Antioxidants | Consumer Trends | Dietary Supplements | Healthcare Trends | Herbs & Botanicals | Immune Function | Probiotics & Prebiotics | Proteins, Peptides, Amino Acids
      The Immunity Imperative

      The Immunity Imperative

      The best way to preserve health is through preventive approaches. These nutraceuticals are on the front lines.
      By Alan Richman, Contributing Writer 06.02.17

    Loading, Please Wait..
    Trending
    • Shiitake Mushroom Extract Appears Helpful In HPV Infections
    • The Functional Chocolate Company Launches Painfree Chocolate
    Breaking News
    • NPA: ‘Major Victory’ in Colorado After Amendment to Eating Disorder Bill
    • GOOD Meat Receives FDA Go-Ahead for Cultured Meat
    • IFF Achieves Industrial-Scale Production of Anaerobic Probiotic Strain
    • Jones Healthcare Group Primed to Help Nutraceutical Brands Comply with New Packaging Rules
    • Nordic Naturals Debuts Probiotic Line in More Than 375 Sprouts Farmer’s Markets
    View Breaking News >
    CURRENT ISSUE

    March 2023

    • Supporting Musculoskeletal Health: Tending to Muscles, Joints, and Bones
    • Dosage and Delivery Innovations Help Manufacturers Meet Common Challenges
    • 2023 Contract Manufacturing Survey
    • Manufacturing Dietary Supplements in Economic Uncertainty
    • Beyond Antioxidants: The Power of Berries
    • A Paradigm Shift for Antioxidants?
    • Ayana Bio on Path to Scale Bioactives Derived from Plant Cell Cultures
    • Nuritas: Leveraging Artificial Intelligence to Speak the Language of Life
    • Dietary Supplement Quality Assurance Programs Critical to Natural Products Industry Success
    • Innovation in Nutraceuticals: Dose Forms and Application Science Help Meet Consumer Demand
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    NPA: ‘Major Victory’ in Colorado After Amendment to Eating Disorder Bill
    GOOD Meat Receives FDA Go-Ahead for Cultured Meat
    IFF Achieves Industrial-Scale Production of Anaerobic Probiotic Strain
    Coatings World

    Latest Breaking News From Coatings World

    HOFFMANN MINERAL to Focus on Comprehensive Sustainability Strategy
    HMG and Prodrive Renew Technical Partnership
    Eastern Coatings Show Sets Schedule for Technical Papers
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    MPO's Most-Read Stories This Week—March 25
    Getinge iCast Receives FDA Premarket Approval
    Tessy Plastics Corp. Celebrates 50th Anniversary
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Willow, Suanfarma Complete Manufacturing Process for Cannabigerol
    Berkshire Sterile to Install nearly 1,500 solar panels at Massachusetts site
    Harm Reduction Therapeutics, Catalent Ink Naloxone Commercial Supply Pact
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Interpack 2023 Introduces New Special Areas and Activities
    eSalon Expands into Over 1,900 CVS Stores Nationwide
    The RealReal Discontinues Beauty Business
    Happi

    Latest Breaking News From Happi

    Clairol Announces First Global Haircare Campaign in Five Years
    Nair’s Prep & Smooth Hair Removal, Walmart’s Accelerator
    ‘Glossier You’ Returns to Glossier’s Fragrance Portfolio
    Ink World

    Latest Breaking News From Ink World

    Weekly Recap: Packaging Inks, Toyo Ink Top This Week’s Stories
    Eastern Coatings Show Announces Schedule for Technical Papers
    Pulse Roll Label Products Adds Sean Labas to Technical Sales Team
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Imageworx details new facility, Avery Dennison tackles recycling and more
    TLMI announces 2022 Eugene Singer Award winners
    Pulse Roll Label Products expands technical sales team
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Weekly Recap: Heartland Polymers Begins Production, Zeta Polimeri Becomes Radici EcoMaterials & More
    Heartland Polymers Begins Production in Alberta
    Zeta Polimeri Becomes Radici EcoMaterials
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    ODT's Most-Read Stories This Week—March 25
    AI is Effective at Documenting Orthopedic Encounters in Hand Surgery
    3D LifePrints Rebrands to Insight Surgery & Launches New Business in Houston
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Weekly Recap: Dave Rahami, Zebra, Dracula Technologies Top This Week’s Stories
    Midsummer, UCLA Collaborate on Perovskite-CIGS Tandem Solar Cells
    HID Reports on Reshaping the Security Industry

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login