An open-label, clinical pilot study was conducted by NIS Labs, and involved healthy individuals experiencing moderate loss of joint range of motion (ROM), and associated recurring pain. The goal of the study was to evaluate the effects of consumption of dried apple peel powder (DAPP) on joint function and range of motion (ROM). Additional in vitro and clinical testing was performed to investigate specific mechanisms of action. A full manuscript of the study has been published in The Journal of Medicinal Food, and a study abstract may be found on the PubMed site.
Study subjects consumed 4.25 grams of AppleActiv DAPP daily for 12 weeks, with evaluations at baseline, 2, 4, 8, and 12 weeks. ROM was evaluated at each visit using dual digital inclinometry. Pain scores were collected using visual analogue scales. Blood draws enabled testing of serum antioxidant protective capacity using the cellular antioxidant protection (CAP-e) bioassay. Additional in vitro testing involved testing of cyclooxygenase-2 (COX-2) and lipoxygenase inhibition, cellular antioxidant protection by the CAP-e bioassay, and formation of reactive oxygen species (ROS) by polymorphonuclear (PMN) cells by flow cytometry.
According to Gitte Jensen, research director at NIS Labs, “The study indicated that daily consumption of AppleActiv DAPP was associated with a statistically significant improvement in serum antioxidant protective status, as well as improved ROM.” She added, “We are pleased with the results of this clinical pilot study, which suggest multifaceted anti-inflammatory properties of dried apple peel powder.”
AppleActiv DAPP is certified organic, and contains a rich polyphenol blend with high levels of antioxidants. In the study, DAPP was shown to increase antioxidant activity, including cell protection from oxidative damage in vitro. The consumption of AppleActiv DAPP daily for 12 weeks showed both inhibited COX-2 and lipoxygenase enzyme activity. The study also observed pain reduction, which may be associated with the improved antioxidant status, and is likely linked to the anti-inflammatory effects of the polyphenols.
For more information: www.appleactiv.com