08.16.11
A study published in the journal Food & Nutrition Sciences indicates Slimaluma, a standardized extract of the plant Caralluma fimbriata, from Gencor Nutrients, has the potential to inhibit hyperplastic obesity by inhibiting pre-adipocyte cell division.
Mouse 3T3-L1 pre-adipocyte cell line samples were treated with different concentrations of the extract standardized against its pregnane glycoside content. The cells were counted at 12-hour intervals, and their viability tested using the MTT assay. The treated cells were subjected to direct and indirect immunofluorescent assays for cyclin D1. Slimaluma inhibited 3T3-L1 cell growth in a dose and duration-dependent manner, with results comparable to those produced by hydroxyurea.
Researchers concluded the Slimaluma appears to inhibit pre-adipocyte cell division by interfering with a mechanism preceding the import of cyclin D1-CDk4/6 complex into the nucleus during the early G1 phase of the cell cycle, suggesting that it has the potential to inhibit hyperplastic obesity. For further information: www.gencorpacific.com
Mouse 3T3-L1 pre-adipocyte cell line samples were treated with different concentrations of the extract standardized against its pregnane glycoside content. The cells were counted at 12-hour intervals, and their viability tested using the MTT assay. The treated cells were subjected to direct and indirect immunofluorescent assays for cyclin D1. Slimaluma inhibited 3T3-L1 cell growth in a dose and duration-dependent manner, with results comparable to those produced by hydroxyurea.
Researchers concluded the Slimaluma appears to inhibit pre-adipocyte cell division by interfering with a mechanism preceding the import of cyclin D1-CDk4/6 complex into the nucleus during the early G1 phase of the cell cycle, suggesting that it has the potential to inhibit hyperplastic obesity. For further information: www.gencorpacific.com
