• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Optimizing Gut Health: Unlocking the Gates to Well-Being

    Sweeteners Market Continues to Broaden with Cleaner Labels and Better Formulations

    Green Business Network Seeks Comment on New Certification for Hemp-CBD Businesses

    Delivering Dietary Supplements that Exceed Consumer Expectations

    Delivering Better Gut Health Supplements
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Ashland Supports the Nature Conservancy Forest Restoration Effort to Help Plant a Billion Trees

    Martin Bauer Announces Installation of Agile Filling System at Bethlehem, PA Facility

    PepsiCo and Ingredion Begin Pilot Partnership with Soil and Water Outcomes Fund

    Innova Market Insights: Sports Nutrition Must Focus on Flavors for Mainstream Consumers

    Probiotic Strain Evidenced to Reduce Iron Deficiency/Anemia Risk
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Martin Bauer Announces Installation of Agile Filling System at Bethlehem, PA Facility

    Innova Market Insights: Sports Nutrition Must Focus on Flavors for Mainstream Consumers

    Probiotic Strain Evidenced to Reduce Iron Deficiency/Anemia Risk

    Longvida Curcumin Extract Receives ANVISA Approval in Brazil

    Curcugen Curcumin Formulation Evidenced to Attenuate Post-Exercise Inflammation
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Ashland Supports the Nature Conservancy Forest Restoration Effort to Help Plant a Billion Trees

    Martin Bauer Announces Installation of Agile Filling System at Bethlehem, PA Facility

    PepsiCo and Ingredion Begin Pilot Partnership with Soil and Water Outcomes Fund

    Innova Market Insights: Sports Nutrition Must Focus on Flavors for Mainstream Consumers

    Probiotic Strain Evidenced to Reduce Iron Deficiency/Anemia Risk
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Innova Market Insights: Sports Nutrition Must Focus on Flavors for Mainstream Consumers

    Probiotic Strain Evidenced to Reduce Iron Deficiency/Anemia Risk

    Curcugen Curcumin Formulation Evidenced to Attenuate Post-Exercise Inflammation

    Good Rāz Launches Taste-Free Vitamin D3 Drops

    In Vitro Study Suggests Bovine Colostrum May Prevent “Leaky Gut”
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Gencor

    Bioenergy Life Science, Inc. (BLS)

    Chenland Nutritionals Inc.

    AIDP

    Vesta Nutra
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    KLK OLEO - Davos Life Science

    Xsto Solutions

    AIDP

    Gencor

    Vesta Nutra
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • eBook
    • Infographics
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Features

    New Roles for Polyphenols

    A 3-Part report on Current Regulations & the State of Science

    Related CONTENT
    • Following the Ascent of Alternative Proteins
    • Antioxidants Adapt to New Growth Avenues
    • IFF Olive Leaf Extract Receives Non-GMO Project, CAIRM Certifications
    • Astaxanthin Microencapsulated with Spirulina Targets ‘Mental Agility’ and Healthy Aging
    • Transforming Health with Nature’s Sunshine
    Paul Gross03.01.09
    Branding of nutraceuticals and other natural products like superfruit juices with antioxidant content infers that polyphenol pigments-flavonoids, anthocyanins, ellagitannins, catechins, proanthocyanidins and others with antioxidant activity in vitro-provide health benefits. However, such marketing defies scientific knowledge because there is no physiological evidence that polyphenols have any such action in humans.

    In July 2008, FDA republished guidance for industry using antioxidant claims, with the terms specified for the regulation of product labels and marketing literature pertaining to antioxidants.

    Stated with the release, FDA declared: "This guidance document restates in plain language the legal requirements set forth in 21 CFR 101.54(f) and (g) and 21 CFR 101.60(c)(1)(iii)(A) concerning dietary supplement use of certain nutrient content claims. This regulation is binding and has the full force and effect of law."


    Is an antioxidant claim a nutrient content claim?



    Yes. "A claim that describes the level of antioxidant nutrients present in a food is a nutrient content claim and may be used on the label or in the labeling of a food when the conditions of use in the regulation are met (21 CFR 101.54(g))."

    In legal context, this quote is an excerpt from Title 21: Food and Drug Administration, Part 101-Food Labeling, Subpart D-Specific Requirements for Nutrient Content Claims. This term defines an "antioxidant" phytochemical as a nutrient only if physiological evidence exists to verify such a qualification. However, as only dietary vitamins A, C and E are verified as physiological antioxidant nutrients, just these vitamins-not polyphenols-qualify for an antioxidant nutrient claim.


    Can I make an antioxidant nutrient content claim for any ingredient in a food?



    No. "An antioxidant nutrient content claim can only be made for nutrients for which there is an RDI established in 21 CFR 101.9 (21 CFR 101.54(g)(1))."

    Demonstrating a Reference Dietary Intake level requires substantial physiological evidence for a role of the candidate compound as an actual nutrient with proven health values to humans. This is established only for vitamins A, C and E as dietary antioxidants in vivo. If a natural health product marketed as an antioxidant does not show good to excellent levels (10-20% DV) of vitamin A, C or E, then the product cannot be branded as an antioxidant.

    Since no evidence exists for plant-derived polyphenols having such qualification, it is unlawful to state or infer that polyphenols in natural health products furnish antioxidant benefits. Products containing only polyphenols and branded as having high antioxidant content mislead the public into believing such products provide antioxidant benefit where no such action has been physiologically proven.


    Does the claim apply to all nutrients listed in 21 CFR 101.9?



    No. "The nutrient that is the subject of the claim must have recognized antioxidant activity. That is, there must be scientific evidence that after it is eaten and absorbed from the gastrointestinal tract, the substance participates in physiological, biochemical or cellular processes that inactivate free radicals or prevent free radical-initiated chemical reactions (21 CFR 101.54(g)(2))."

    The terms of the regulatory document are especially restrictive for excluding polyphenols as physiological antioxidants because:

    1. It is unlikely that polyphenols survive the gastric acid-enzyme environment of the stomach in the same chemical form as in the product or natural fruit.

    2. Polyphenols do not have a biochemically confirmed mechanism of action or participation in any biological processes in vivo.

    3. Polyphenols have not been proven in physiological studies to inactivate free radicals or block radical-initiated events.


    Does the label claim have to include the name of the nutrient that is an antioxidant, or can the claim simply say "antioxidants?"



    "The names of the nutrients that are the antioxidants must appear in the claim. For example, 'high in antioxidant vitamins C and E.'

    "Alternatively, when used as part of a nutrient content claim, the term 'antioxidant' or 'antioxidants' (such as "high in antioxidants"), may be linked by a symbol (such as an asterisk) that refers to the same symbol that appears elsewhere on the same panel of a product label followed by the name or names of the nutrients with the recognized antioxidant activity."

    This term further defines the role of-and frankly, it absolutely excludes-polyphenols in branded products or mentioned on a product label as antioxidants.

    Branding a product as an 'antioxidant' 1) implies the product or extract has substantiated science proving its physiological activity; 2) may deceptively persuade consumers to buy such a product expecting a health benefit; and 3) promotes an 'antioxidant' product as beneficial to consumer health.

    As no physiological evidence exists for polyphenol antioxidant activity, it is contrary to FDA regulations and law when manufacturers brand products as antioxidants unless sufficient scientific evidence exists to confirm nutrient status.

    As summarized later in this report by Drs. Balz Frei, James Joseph and colleagues, molecules like polyphenols-assumed to be physiological antioxidants-may actually serve roles apart from antioxidant functions. Included may be modification of on-off switches for enzymes, facilitation of receptor binding as a selective ligand or mimic, or cell-cell signaling at concentrations lower than anticipated for antioxidant activity.

    Polyphenols actually are known to facilitate synthesis of glutathione, the most prevalent endogenous antioxidant, so they could play a role in increasing content of antioxidant molecules already present in the body.

    In conclusion, emphasis of polyphenols as physiological antioxidant ingredients in superfruit or other natural health products is scientifically baseless, deceptive and unlawful by promoting unproved antioxidant health benefits that may induce consumer purchases.




    Non-Antioxidant Roles for Dietary Flavonoids: Reviewing the relevance to cancer and cardiovascular diseases.



    By Jane Higdon, PhD, Victoria Drake, PhD & Balz Frei, PhD
    Linus Pauling Institute
    Oregon State University



    Flavonoids represent a family of some 5000 plant compounds having common chemical structures called polyphenols. Flavonoids can be divided into chemically-related subclasses of polyphenols called isoflavones (found in soy products), flavanones (such as naringenin from citrus fruits), flavanols (e.g., catechins from tea or cocoa), flavonols (e.g., quercetin from many fruits and vegetables) and anthocyanidins (from berries and grapes).

    Following ingestion, flavonoids are likely to undergo a change in chemical structure during exposure to stomach acids and enzymes. Flavonoids are poorly absorbed into blood and rapidly eliminated from the body; thus, flavonoids have low eventual biological availability or 'bioavailability'-the fraction of ingested substance reaching target organs. Bioavailability is only about 10% of total intake for flavonoids like soy isoflavones and citrus flavonones, while it is even lower (about 2% of total intake) for most other flavonoids, including anthocyanidins, catechins and quercetin. Unfortunately, many test tube experiments published in the scientific literature showing strong antioxidant activity of flavonoids have used very high, unphysiological concentrations and parent chemical structures (rather than metabolites) of flavonoids. When these results are conveyed to the public, a misunderstanding may occur about the actual biological significance of flavonoids, leading consumers to believe incorrectly that flavonoids have important antioxidant value.


    What follows is a summary of possible actions of dietary flavonoids in human physiology.



    1) Minimal or no direct antioxidant activity. Flavonoids have antioxidant activity in test tube experiments because they effectively scavenge free radicals. However, in the human body, flavonoids are not effective antioxidants because, even with high levels of dietary intake, cellular flavonoid concentrations are 100-1000 times lower than concentrations of other important cellular antioxidants, including vitamins C and E, uric acid and glutathione. Moreover, flavonoid metabolites often have even lower antioxidant activity than their parent flavonoids. For these reasons, the relative contribution of dietary flavonoids to antioxidant function in the body is likely very small and physiologically negligible.

    2) Potential estrogenic and anti-estrogenic activities. Soy isoflavones are referred to as "phytoestrogens"-plant-derived compounds that exert estrogen-like effects rather than antioxidant functions. Estrogen is a hormone that binds to estrogen receptors located in bone, liver, heart, brain and reproductive tissue. Soy isoflavones can either mimic the effects of estrogen in some tissues or block its effects in others. Estrogenic effects in various tissues could help maintain bone density and improve cholesterol levels, while anti-estrogenic effects in reproductive tissue could potentially decrease the risk of hormone-associated cancers (e.g., breast, uterine and prostate cancers).

    3) Potential effects on cell-signaling pathways. Cells can respond to a variety of stresses or signals by increasing or decreasing activity of "cell-signaling pathways" (also called "signal transduction pathways"). These pathways regulate many processes, including cell growth, cell proliferation and removal of damaged cells (programmed cell death or "apoptosis"). Although it was originally assumed that flavonoids exert antioxidant effects in the body, it has become increasingly clear that instead they modulate cell-signaling pathways.

    Inside cells, the concentration of flavonoids needed to affect cell-signaling mechanisms is much lower than that needed to affect cellular antioxidant capacity, so this evidence is consistent with the low flavonoid concentrations kept in the body. The results of many laboratory experiments suggest that flavonoids may selectively inhibit a group of cell-signaling enzymes called kinases, which are important in maintaining normal cell function. Increased activity of these kinases appears to be responsible for the start of various chronic diseases; flavonoids may selectively inhibit kinases, thereby lowering chronic disease risk.

    In most of the following examples, flavonoids in their native chemical structure and in relatively high concentrations were applied directly into the experimental preparation (did not pass through the stomach). The results indicate that changes in cell signaling by flavonoids could help prevent cancer by:

    Increasing levels of detoxification enzymes: Detoxification enzymes carry out reactions that help excrete potentially toxic or carcinogenic (cancer-causing) compounds.

    Preserving normal cell cycle regulation: The "cell cycle" is the sequence of events involving growth, replication and division of a cell. If DNA damage occurs, the cell cycle can be transiently arrested in order for the DNA to be repaired-or if the damage is irreparable-for activation of pathways leading to removal of the damaged cell. Cancer may develop if DNA mutations are propagated, for instance, in the case of defective cell cycle regulation. Flavonoids appear to maintain normal cell cycle.

    Inhibiting proliferation and inducing programmed cell death (apoptosis): In contrast to normal cells, cancer cells proliferate rapidly and cannot respond to cell signals that initiate apoptosis. Flavonoids stimulate apoptosis in isolated cancer cells, so they may be important as dietary agents combating cancer.

    Inhibiting tumor invasion and angiogenesis: With the aid of enzymes called matrix-metalloproteinases, cancer cells invade normal tissue. Angiogenesis-the development of new blood vessels-is necessary for the growth of invasive, cancerous tumors. Flavonoids appear to act against both the invasion process and angiogenesis.

    Decreasing inflammation: Inflammation can result in increased production of free radicals by inflammatory enzymes, as well as the release of inflammatory mediators that promote cell proliferation and angiogenesis and inhibit apoptosis. In test tube studies, flavonoids act against inflammatory mechanisms.


    Modulation of cell-signaling pathways by flavonoids could help prevent cardiovascular diseases (mainly heart attacks and strokes) by:



    Decreasing inflammation: Atherosclerosis is now recognized as an inflammatory disease of the arterial wall. Accordingly, several markers of inflammation-such as C-reactive protein (CRP)-have been associated with increased risk of heart attacks and strokes. In test tube experiments and in preliminary studies with animals and humans, there is evidence that dietary flavonoids may lower CRP and inhibit atherosclerosis resulting from inflammation of the arterial wall.

    Decreasing vascular endothelial cell adhesion: Early in the development of atherosclerosis, inflammatory white blood cells are recruited from the blood to the arterial wall. This event is dependent on so-called adhesion molecules produced by vascular endothelial cells that line the inner walls of blood vessels. This process is inhibited by flavonoids.

    Increasing endothelial nitric oxide production: An enzyme called eNOS produces the chemical nitric oxide, which is needed to maintain normal blood vessel relaxation (vasodilation). Impaired nitric oxide-dependent vasodilation is linked to an increased risk of cardiovascular diseases. Nitric oxide also may reduce inflammation and inhibit smooth muscle cell proliferation, important factors in atherosclerosis. Dietary flavonoids (from tea or cocoa) may increase eNOS activity by binding to estrogen receptors (above) and stimulating cell-signaling pathways that activate eNOS.

    Decreasing platelet aggregation: Platelet aggregation is one of the first steps in the formation of a blood clot that can occlude a coronary or cerebral artery, leading to a heart attack or stroke, respectively. Thus, inhibiting platelet aggregation-an action that flavonoids appear to have-is important in the prevention of cardiovascular diseases.

    In summary, dietary flavonoids cannot be significant antioxidants in humans, but they may affect a variety of cell-signaling pathways, possibly influencing the onset and progression of cancer or cardiovascular diseases.




    Berry Polyphenols: Exploring non-antioxidant theory and potential mechanisms of brain aging.



    By James Joseph, PhD, Barbara Shukitt-Hale, PhD & Lauren Willis, PhD
    USDA-Agricultural Research Service
    Human Nutrition Research Center on Aging at Tufts University



    Dietary polyphenols have been shown to delay and even reverse age-related cognitive decline in laboratory animals via mechanisms associated with antioxidant mechanisms. However, dietary supplementation with blueberries and strawberries in rats also induces brain changes not strictly involving antioxidant actions.

    Oxidative damage occurs when oxygen radicals produced as a byproduct of normal metabolism accumulate from over-production or decreased capacity of cells to neutralize free radicals.

    During aging, neuronal failure to process and complete motor skills occurs in brain structures-e.g., hippocampus, striatum and cerebellum-and may result from oxidative damage to proteins, membrane lipids and enzymes involved in neuron survival and communication. Neurons in the aged brain fail to regulate intracellular ion concentrations, leading to deficits in cell communication. Aging also causes activation of brain support cells called glia, possibly worsening neuron damage by release of toxic cell chemicals.


    Brain Actions of Polyphenols In Vivo



    Blueberries and other dark fruits are known for their polyphenolic chemicals, particularly anthocyanins, in skin and pulp. Dietary anthocyanins improve cognitive performance and cell changes in the hippocampus of rats. When considering brain uptake, dietary compounds must not only pass through the digestive system and enter the blood, but must also cross the blood-brain barrier to access neural tissue. Following chronic supplementation with blueberries in rats, anthocyanins locate in the hippocampus and cortex, indicating they must have passed through the blood-brain barrier.

    Due to their beneficial effects on age-related cognitive decline and accumulation in brain structures involved in learning and memory, polyphenols may act directly on brain cells. They may have a variety of effects on the aging brain, including changes in gene expression, signaling molecule activity, and neuron survival mechanisms.

    Blueberry polyphenols appear to directly affect neuronal processes such as survival mechanisms and intracellular signals. Exposure of hippocampal cells in culture to different stressors, like dopamine or beta-amyloid protein of Alzheimer's disease, decreases ability of neurons to control levels of calcium, leading to cell death. When hippocampal cells were treated with blueberry extracts, ability to control cell calcium was restored.


    Possible Molecular Actions of Polyphenols in the Brain



    In other rat studies, blueberry consumption reversed stress-induced alterations in cell signaling molecules in the hippocampus and induced activation of a multi-functional transcription factor required for long-term memory. This activation was associated with increased expression of a growth factor called "brain-derived neurotrophic factor" involved in brain aging, stress responses and signaling molecules involved in cell survival.

    These studies clarify a new concept that berry polyphenols, although possibly being antioxidants in the aged brain, also affect brain aging processes. Potential mechanisms involved include changes in 1) gene expression, 2) signaling activity, 3) brain cell survival mechanisms and 4) calcium ion transport in and out of cells.

    As examples, studies show that oxidative and inflammatory stressors activate signaling molecules within neurons. Several critical elements that may lead to cell protection from these stressors include enzymes and growth factors involved in cell survival and protection. Recent research has shown that dietary blueberry polyphenols protect hippocampal neurons from low-oxygen stress and enhance protection and growth of brain cells.

    Importantly, in rat experiments, a signaling molecule enzyme was involved in memory of fear conditions, learning and "place" memory. One other signaling enzyme, protein kinase C (PKC), regulated synapse responses and memory mechanisms. PKC activity may be important in memory formation, particularly memory of place and learning. A blueberry diet in rats stimulates genes associated with cell survival, including one involved in cell-to-cell communication.

    In conclusion, an antioxidant explanation for dietary effects of berries on brain cells and behavior involves only a small probable benefit. Others possibly include cell protection, reduced cell responses to inflammatory stimuli, and increased ability for brain cells to communicate.

    References furnished upon request.
    About the authors: Paul Gross, PhD, is an industry consultant and author, specializing in superfruits. Jane Higdon, PhD (deceased), Victoria Drake, PhD, and Balz Frei, PhD, represent the Linus Pauling Institute at Oregon State University in Corvallis, OR. James Joseph, PhD, Barbara Shukitt-Hale, PhD, and Lauren Willis, PhD, represent the USDA Agricultural Research Service, Human Nutrition Research Center on Aging at Tufts University in Boston, MA.

    Related Searches
    • Inflammation
    • Healthy Aging
    • Research
    • Enzymes
    Related Knowledge Center
    • Skin Health
    • Antioxidants
    • Inflammation
    Suggested For You
    Antioxidants Adapt to New Growth Avenues Antioxidants Adapt to New Growth Avenues
    Following the Ascent of Alternative Proteins Following the Ascent of Alternative Proteins
    IFF Olive Leaf Extract Receives Non-GMO Project, CAIRM Certifications IFF Olive Leaf Extract Receives Non-GMO Project, CAIRM Certifications
    Astaxanthin Microencapsulated with Spirulina Targets ‘Mental Agility’ and Healthy Aging Astaxanthin Microencapsulated with Spirulina Targets ‘Mental Agility’ and Healthy Aging
    Unfolding the Interrelationship Between GI Health & Immunity Unfolding the Interrelationship Between GI Health & Immunity
    Understanding FTC Standards for Claims Substantiation Understanding FTC Standards for Claims Substantiation
    Transforming Health with Nature’s Sunshine Transforming Health with Nature’s Sunshine
    TREHA Trehalose Available As ‘Natural Flavor’ TREHA Trehalose Available As ‘Natural Flavor’
    ConsumerLab.com Tests Popular Vitamin D Supplements ConsumerLab.com Tests Popular Vitamin D Supplements
    Gottlieb Confirmed to Lead FDA Gottlieb Confirmed to Lead FDA
    Probi Launches Select Range of Probiotics Probi Launches Select Range of Probiotics
    An Interview with George A. Burdock, PhD, of the Burdock Group An Interview with George A. Burdock, PhD, of the Burdock Group
    Blueberries May Improve Cognition in Older Adults Blueberries May Improve Cognition in Older Adults
    Scientists Respond to Coverage of Curcumin Scientists Respond to Coverage of Curcumin
    Study Finds Probiotics May Improve Cognition in Alzheimer Study Finds Probiotics May Improve Cognition in Alzheimer's Patients

    Related Features

    • Cognitive Function | Dietary Supplements | Digestive Health | Enzymes | Fiber & Carbohydrates | Healthcare Trends | Immune Function | Probiotics & Prebiotics | Research
      Optimizing Gut Health: Unlocking the Gates to Well-Being

      Optimizing Gut Health: Unlocking the Gates to Well-Being

      Tied to so many facets of wellness, the gut microbiome will continue to be an attractive target for nutritional products.
      By Sean Moloughney, Editor 04.08.21

    • Herbs & Botanicals | Quality & Safety | Regulations
      Green Business Network Seeks Comment on New Certification for Hemp-CBD Businesses

      Green Business Network Seeks Comment on New Certification for Hemp-CBD Businesses

      The draft standard addresses social and environmental initiatives in 10 different categories.
      By Fran Teplitz, Executive Co-Director, Green America 04.08.21

    • Consumer Trends | Cosmeceuticals / Nutricosmetics | Herbs & Botanicals | Skin Health
      Navigating New Product Development in CBD

      Navigating New Product Development in CBD

      Advice for personal care brands that want to market their own topical products.
      By Christine Esposito, Managing Editor, Happi 04.01.21


    • Consumer Trends | Dietary Supplements | Herbs & Botanicals | Regulations
      Untapped Potential: CBD Food & Supplement Market Still in Regulatory Limbo

      Untapped Potential: CBD Food & Supplement Market Still in Regulatory Limbo

      Without a federal regulatory framework for hemp-derived CBD dietary supplements, stakeholders across the value chain are feeling the effects.
      By Sean Moloughney, Editor 04.01.21

    • Dietary Supplements | Herbs & Botanicals | Quality & Safety | Regulations
      USDA’s Final Rule on Hemp: Experts Discuss Ramifications

      USDA’s Final Rule on Hemp: Experts Discuss Ramifications

      There are mixed opinions coming from the industry on new regulations that will replace those issued in the interim.
      By Mike Montemarano, Associate Editor, Nutraceuticals World 04.01.21

    • Cosmeceuticals / Nutricosmetics | Dietary Supplements | Herbs & Botanicals | Natural/Organic | Skin Health
      A Closer Look at cbdMD: A Wellness Company to Watch

      A Closer Look at cbdMD: A Wellness Company to Watch

      This longtime proponent of cannabidiol components has branched out into personal care.
      By Melissa Meisel, Associate Editor, Happi 04.01.21


    • Cosmeceuticals / Nutricosmetics | Healthcare Trends | Herbs & Botanicals | Skin Health
      Mary Jane’s Botanicals: Unique Formulations Hand-Crafted with Premium Ingredients

      Mary Jane’s Botanicals: Unique Formulations Hand-Crafted with Premium Ingredients

      Dahlia Mertens discusses the early days of topical cannabis products, the CBD bubble, and how she’s striving to improve people’s lives.
      By Sheldon Baker, Area Code 420 04.01.21

    • Cosmeceuticals / Nutricosmetics | Delivery & Dosage Technologies | Healthcare Trends | Herbs & Botanicals | Quality & Safety | Regulations
      The Cannabis Glow Up

      The Cannabis Glow Up

      The notorious plant rises from its troubled history to provide new possibilities in cosmetics.
      By Nicole Foss, MBA, MSN, RN, NeXtraction 04.01.21

    • Delivery & Dosage Technologies | Herbs & Botanicals | Research
      Supporting CBD Science: The Path to Claims

      Supporting CBD Science: The Path to Claims

      Pharmacokinetics study showed Caliper CBD products absorbed faster than CBD oil and isolate.
      By Keith Woelfel, Director of R&D, Caliper Foods 04.01.21


    • Consumer Trends | Dietary Supplements | Healthcare Trends | Healthy Aging | Immune Function | Research
      Personalized Nutrition: Science & Innovation Bring Concept to Life

      Personalized Nutrition: Science & Innovation Bring Concept to Life

      This rapidly developing field could be positioned to catalyze a new health paradigm.
      By Sean Moloughney, Editor 03.03.21

    • Antioxidants | Dietary Supplements | Energy | Eye Health | Healthy Aging | Herbs & Botanicals | Immune Function | Vitamins
      Antioxidants Adapt to New Growth Avenues

      Antioxidants Adapt to New Growth Avenues

      Brands have opportunities to reach consumers in search of general health and wellness protection, as well as those who opt for targeted solutions.
      By Sean Moloughney, Editor 03.03.21

    • Consumer Trends | Delivery & Dosage Technologies | Dietary Supplements | Healthcare Trends | Healthy Aging | Nutrition Bars & Snacks | Proteins, Peptides, Amino Acids | Sports Nutrition | Weight Management/Weight Loss
      Following the Ascent of Alternative Proteins

      Following the Ascent of Alternative Proteins

      As the protein palate of global consumers turns greener, concerted efforts to create nutritionally optimized, appealing options abound.
      By Mike Montemarano, Associate Editor 03.03.21


    • Consumer Trends | Delivery & Dosage Technologies | Dietary Supplements | Healthcare Trends | Healthy Aging | Proteins, Peptides, Amino Acids | Research | Sports Nutrition
      Performance, Personalization Continue Driving the Market for Stalwart Protein Supplements

      Performance, Personalization Continue Driving the Market for Stalwart Protein Supplements

      As the line between athletes and active consumers continues to blur, a growing number of protein supplement users seek clean, powerful, and personal solutions.
      By Mike Montemarano, Associate Editor 03.03.21

    • Healthcare Trends | Natural/Organic | Vitamins
      There Couldn’t Be a Better Time for Change—An Open Invitation from Organic & Natural Health

      There Couldn’t Be a Better Time for Change—An Open Invitation from Organic & Natural Health

      Supporting historically Black colleges and universities can help open doors to leadership and introduce students to natural and organic career pathways.
      By Karen Howard, CEO and Executive Director, Organic & Natural Health Association 03.03.21

    • Cognitive Function | Consumer Trends | Dietary Supplements | Energy | Functional Foods & Beverages | Healthcare Trends | Herbs & Botanicals | Vitamins
      Saving Energy: Brands Must Offer Grown-Up and Personalized Products to Compete

      Saving Energy: Brands Must Offer Grown-Up and Personalized Products to Compete

      From dual and triple action formulas to natural and organic ingredients, success in the energy market is about way more than the loud packaging of the past.
      By Melissa Kvidahl Reilly, Contributing Writer 03.03.21

    Trending
    • CGA-7 Green Coffee Extract By Vidya Herbs Achieves Self-Affirmed GRAS Status
    • Review Covers Role Of Vitamin K2 In The ‘Calcium Paradox’
    • 6th Annual Dietary Supplements Regulatory Summit Scheduled For July 13
    • Omniactive's Capsimax Shown To Support Weight Management Through Increased Metabolic Rate
    • Euromonitor Explores Cannabis User Profiles
    Breaking News
    • Ashland Supports the Nature Conservancy Forest Restoration Effort to Help Plant a Billion Trees
    • Martin Bauer Announces Installation of Agile Filling System at Bethlehem, PA Facility
    • PepsiCo and Ingredion Begin Pilot Partnership with Soil and Water Outcomes Fund
    • Innova Market Insights: Sports Nutrition Must Focus on Flavors for Mainstream Consumers
    • Probiotic Strain Evidenced to Reduce Iron Deficiency/Anemia Risk
    View Breaking News >
    CURRENT ISSUE

    April 2021

    • Sweeteners Market Continues to Broaden with Cleaner Labels and Better Formulations
    • Green Business Network Seeks Comment on New Certification for Hemp-CBD Businesses
    • Delivering Dietary Supplements that Exceed Consumer Expectations
    • Delivering Better Gut Health Supplements
    • Optimizing Gut Health: Unlocking the Gates to Well-Being
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Ashland Supports the Nature Conservancy Forest Restoration Effort to Help Plant a Billion Trees
    Martin Bauer Announces Installation of Agile Filling System at Bethlehem, PA Facility
    PepsiCo and Ingredion Begin Pilot Partnership with Soil and Water Outcomes Fund
    Coatings World

    Latest Breaking News From Coatings World

    AkzoNobel Shareholders Approve Final Dividend at Annual General Meeting
    PPG Maintains EcoVadis Gold Rating
    Sustainable Plastics Will Make Up More Than 15% of Production by 2030
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Getinge Receives FDA Clearance for Multiple Products
    Study Shows Benefits of CCHD Screening Using Masimo SET Pulse Oximetry
    TEAM Technologies Acquires ViruDefense
    Contract Pharma

    Latest Breaking News From Contract Pharma

    RDIF, Minapharm to Make Over 40M Doses of the Sputnik V Vaccine in Egypt
    Bora Pharmaceuticals Completes Health Canada Inspection
    Nanoform, Aprecia Partner to Advance 3DP Nanomedicines
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Johnson & Johnson Reports Sales Increase in First Quarter of 2021
    THG Launches Recycling Program in UK
    Knoll Printing & Packaging Commits to a Healthy Ocean and Planet
    Happi

    Latest Breaking News From Happi

    L’Oréal Successfully Defends Itself In Patent Infringement Lawsuit
    TFF Names 2021 Honorees for Lifetime Achievement Perfumer and Hall of Fame
    Ashland Donates $20,000 To Help Plant Trees
    Ink World

    Latest Breaking News From Ink World

    Kumon North America Adds Speedmaster XL 106 from Heidelberg
    Acrylic Resins Market Worth $21.9 Billion by 2025: MarketsandMarkets
    SE-DA Invests in Kornit Presto S
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Ashland commits to forest restoration
    Epson upgrades SurePress demo facility
    Xeikon helps converters navigate toner and inkjet
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Savaré Strengthens Technical Support for the Americas
    FiberVisions, Avgol Partner with Polymateria
    High-Tech Conversions Launches Wipes Dispenser
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    FDA Clears Orthofix's 3D-Printed FORZA Titanium TLIF Spacer System
    Patients Conclude Clinical Visits in Knee Osteoarthritis Treatment Study
    SeaSpine Begins Limited Rollout of WaveForm TO 3D-Printed Interbodies
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Identiv, Ameta International Announce US, Canadian Distribution Partnership
    Adesis Achieves ISO 9001:2015 Certification
    Louis Widmer SA Complies with EU Anti-Counterfeiting Directive with Zebra Technologies’ Solution

    Copyright © 2021 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login