• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Citrus Support for the Blood Glucose-Immune System Connection

    A Glance At The Eye Health Market

    The Value of Vitamin D Testing

    A Growing Need for Mineral Supplementation

    More Than Just A Trend: Supplements Embedded in Consumer Health Regimens
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Ingredient Manufacturers Discuss the E-Sports Market

    Euromonitor Names Top Ten Trends for 2021

    Study Highlights Differences Between EPA's and DHA's Effect on Sleep

    BGG Obtains U.S. Patent on AstaZine Natural Astaxanthin for Heart Function During Exercise

    Qualitas Health/iwi Raises $10 Million in Investment Round
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Ingredient Manufacturers Discuss the E-Sports Market

    Study Highlights Differences Between EPA's and DHA's Effect on Sleep

    An Interview with Michael Bentley, President, SierraSIl

    Themes For The Long Haul

    CBD in Europe: News from the Front
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Ingredient Manufacturers Discuss the E-Sports Market

    Euromonitor Names Top Ten Trends for 2021

    Study Highlights Differences Between EPA's and DHA's Effect on Sleep

    A Growing Need for Mineral Supplementation

    An Interview with Michael Bentley, President, SierraSIl
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Ingredient Manufacturers Discuss the E-Sports Market

    Euromonitor Names Top Ten Trends for 2021

    Study Highlights Differences Between EPA's and DHA's Effect on Sleep

    ‘Follow the Science’ Often Misses the Mark with Nutrition

    Botanical Research: Botanicals & Immunity, Kava Challenges, Turmeric Therapeutics and More
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Nutrition21, LLC

    Aiya America (Matcha by Aiya)

    Verdure Sciences

    Indena USA, Inc.

    Chenland Nutritionals Inc.
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Chenland Nutritionals Inc.

    Aiya America (Matcha by Aiya)

    Sabinsa Corporation

    Indena USA, Inc.

    Nutrition21, LLC
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • eBook
    • Infographics
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Research Expands on Use of Sabinsa’s Curcumin C3 Complex as Adjunct to Chemotherapy

    Combination of curcumin with FOLFOX represents a safe and tolerable treatment with potential to provide patient benefit.

    Related CONTENT
    • Research Expands on Use of Curcumin C3 Complex as Adjunct to Chemotherapy
    • Sabinsa Self-Affirms GRAS Status of Curcumin C3 Reduct
    • Sabinsa to Feature New Patent-Protected Products
    • Publication Provides Comprehensive Overview of Curcumin Research
    • Turmeric & Curcumin: Rising Stars of the Nutrition World
    07.08.19
    In continuation of two earlier related studies, researchers at the University of Leicester in the U.K. published the results of a phase IIa, open-labeled trial in which 27 subjects with metastatic colorectal cancer were randomized to take FOLFOX or FOLFOX + Curcumin C3 Complex (CUFOX). The study was directed toward the evaluation of safety, and efficacy of treatment via progression-free survival and overall survival. In general, CUFOX was well tolerated by all the subjects. Where causality was reported as possibly or probably related to curcumin were primarily gastrointestinal in nature, with the most common being diarrhea. Results were published in the Journal of Nutrition.
     
    In the per-protocol group median progression-free survival was 171 days for FOLFOX and 320 days for CUFOX. Median overall survival was 200 days for FOLFOX and 596 days for CUFOX. This is the first randomized controlled trial of CUFOX in metastatic colorectal subjects which has shown the safety and tolerability of CUFOX in subjects.
     
    The authors concluded that “…combination of curcumin with FOLFOX chemotherapy represents a safe and tolerable treatment with potential to provide patient benefit,” and that a phase III trial is warranted.
     
    “Research examining the use of drugs and nutraceuticals together is an exciting new direction to investigate,” said N. Kalyanam, PhD, Sabinsa’s president of R&D. “Sabinsa continues to build on science and contribute to the extensive knowledge base of curcumin for better health for all.”
     
    The study, Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial, was published in the Journal of Nutrition: doi/10.1093/jn/nxz029/5499032.
     
    The study protocol, Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomized control trial, was previously published in Trials 2015 and can be accessed here: doi.org/10.1186/s13063-015-0641-1.
     
    A previous research article on a two-part study, Curcumin  inhibits  cancer  stem  cell  phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy, was published in Cancer Letters in  2015 (doi: 10.1016/j.canlet.2015.05.005). The first part of the study included an ex vivo model to test the efficacy of the curcumin and FOLFOX therapy on cancer liver metastases. The second part included a phase I dose escalation study, which evaluated the safety and tolerability of curcumin during FOLFOX chemotherapy. Overall, the study results indicated that the combination of curcumin and 5-FU/oxaliplatin reduced the number of spheroids and downregulated cancer stem cells markers such as CD44, CD166, and ALDH activity. In the phase I dose escalation study, curcumin was found to be safe and tolerable up to a dose of 2 g in the colorectal cancer with liver metastases subjects.
     
    Related Searches
    • Nutrition
    • Health
    • Cancer
    • Nutraceuticals
    Related Knowledge Center
    • Research
    • Herbs & Botanicals
    • Cancer Risk
    Suggested For You
    Research Expands on Use of Curcumin C3 Complex as Adjunct to Chemotherapy Research Expands on Use of Curcumin C3 Complex as Adjunct to Chemotherapy
    Sabinsa Self-Affirms GRAS Status of Curcumin C3 Reduct Sabinsa Self-Affirms GRAS Status of Curcumin C3 Reduct
    Sabinsa to Feature New Patent-Protected Products Sabinsa to Feature New Patent-Protected Products
    Publication Provides Comprehensive Overview of Curcumin Research Publication Provides Comprehensive Overview of Curcumin Research
    Turmeric & Curcumin: Rising Stars of the Nutrition World Turmeric & Curcumin: Rising Stars of the Nutrition World
    Sabinsa Obtains Patents for ForsLean Coleus Forskohlii Extract Related to Energy Balance Sabinsa Obtains Patents for ForsLean Coleus Forskohlii Extract Related to Energy Balance
    Excellence in Research and Manufacturing Excellence in Research and Manufacturing
    Sabinsa Appoints Lori Diez Sales Manager- Texas Sabinsa Appoints Lori Diez Sales Manager- Texas
    Sabinsa Shagandha Ashwagandha Root Extract 2.5% Meets USP Monograph Sabinsa Shagandha Ashwagandha Root Extract 2.5% Meets USP Monograph

    Related Breaking News

    • Breaking News | Dietary Supplements | Energy | Mood Health & Sleep | Omega-3s | Research | Research News
      Study Highlights Differences Between EPA

      Study Highlights Differences Between EPA's and DHA's Effect on Sleep

      With different biological mechanisms, these two omega-3 fatty acids have unique roles to play in sleep quality, efficiency, and subjective feelings of rest.
      01.20.21

    • Antioxidants | Breaking News | Cardiovascular Health | Certifications, Approvals & Patents | Marine Nutraceuticals | Research | Sports Nutrition | Supplier News
      BGG Obtains U.S. Patent on AstaZine Natural Astaxanthin for Heart Function During Exercise

      BGG Obtains U.S. Patent on AstaZine Natural Astaxanthin for Heart Function During Exercise

      Results of a clinical trial found subjects taking AstaZine experienced heart rates on average 10% lower during endurance training than the placebo group.
      01.18.21

    • Bone & Joint Health | Breaking News | Dietary Supplements | Healthy Aging | Herbs & Botanicals | Inflammation | Natural/Organic | Research | Research News
      Cistanche Tubulosa Botanical Shown to Attenuate Locomotive Syndrome

      Cistanche Tubulosa Botanical Shown to Attenuate Locomotive Syndrome

      In an aging society, preventing dysfunction in the ability to walk is key to long-term quality of life for many.
      01.18.21


    • Breaking News | Cognitive Function | Dietary Supplements | Infant & Children's Health | Medical Nutrition | Omega-3s | Research | Research News
      Maternal Dietary Intake of Fish, Omega-3s, and Omega-6s Linked to Child Neurodevelopment

      Maternal Dietary Intake of Fish, Omega-3s, and Omega-6s Linked to Child Neurodevelopment

      A large-scale epidemiological study found that omega-6 fatty acids are also an important component for development down the line.
      01.18.21

    • Breaking News | Diabetes & Blood Sugar Management | Functional Foods & Beverages | Healthcare Trends | Medical Nutrition | Research | Research News | Weight Management/Weight Loss
      Short Term Low-Carb Diet Linked to Remission of Type 2 Diabetes

      Short Term Low-Carb Diet Linked to Remission of Type 2 Diabetes

      While most benefits diminished within a year, researchers point to this eating pattern as a possible therapy.
      01.18.21

    • Breaking News | Diabetes & Blood Sugar Management | Energy | Healthcare Trends | Healthy Aging | Inflammation | Medical Nutrition | Research | Research News | Weight Management/Weight Loss
      Brown Fat Associated with Reductions in Chronic Disease Risk

      Brown Fat Associated with Reductions in Chronic Disease Risk

      A study of 50,000 people highlighted that this clinical target is well worth investigating in the field of nutrition.
      01.15.21


    • Breaking News | Dietary Supplements | Digestive Health | Healthcare Trends | Immune Function | Medical Nutrition | Proteins, Peptides, Amino Acids | Research | Research News
      NIH Study Identifies Antibacterial Properties in Taurine

      NIH Study Identifies Antibacterial Properties in Taurine

      The amino acid helps the gut “recall” prior infections to kill invading bacteria, the authors of the study said.
      01.15.21

    • Antioxidants | Breaking News | Dietary Supplements | Herbs & Botanicals | Inflammation | Natural/Organic | Research | Supplier News
      Eriocitrin Shown to Have Metabolic Benefits in Recent Study

      Eriocitrin Shown to Have Metabolic Benefits in Recent Study

      This lemon-sourced flavonone was assessed for benefits to oxidative stress, inflammation, and the metabolism of glucose and lipids in mice.
      01.14.21

    • Breaking News | Herbs & Botanicals | Natural/Organic | Quality & Safety | Regulations | Regulatory News
      AHPA Requests FDA Take a New Approach on Produce Regulation Affecting Herbs

      AHPA Requests FDA Take a New Approach on Produce Regulation Affecting Herbs

      Many herbs are subject to the same requirements as vegetables which are eaten raw.
      01.14.21


    • Breaking News | Dietary Supplements | Healthcare Trends | Immune Function | Inflammation | Medical Nutrition | Natural/Organic | Omega-3s | Research | Research News
      Preliminary Study Suggests Link Between Omega-3s and Lower COVID-19 Death Rates

      Preliminary Study Suggests Link Between Omega-3s and Lower COVID-19 Death Rates

      While a long stretch from thresholds of significance, the researchers are seeking to further substantiate these initial findings.
      01.12.21

    • Breaking News | Cognitive Function | Dietary Supplements | Healthcare Trends | Infant & Children's Health | Medical Nutrition | Research | Research News | Sexual & Reproductive Health | Vitamins | Women's Health
      Maternal Vitamin D Concentrations During Gestation Benefits Child Cognitive Development

      Maternal Vitamin D Concentrations During Gestation Benefits Child Cognitive Development

      These findings further substantiate the need for proper nutrition for mothers especially at risk of deficiency.
      01.11.21

    • Breaking News | Digestive Health | Fiber & Carbohydrates | Functional Foods & Beverages | Healthcare Trends | Healthy Aging | Medical Nutrition | Mood Health & Sleep | Natural/Organic | Probiotics & Prebiotics | Research | Research News | Women's Health
      Dietary Fiber Intake Associated with Lower Risk for Depression in Premenopausal Women

      Dietary Fiber Intake Associated with Lower Risk for Depression in Premenopausal Women

      The North American Menopause Society said that the link is likely to be explained through gut-brain interactions.
      01.11.21


    • Breaking News | Dietary Supplements | Healthcare Trends | Immune Function | Medical Nutrition | Research | Research News | Vitamins
      Study Links Vitamin D Deficiency to Incidence and Worsened COVID-19 Outcomes

      Study Links Vitamin D Deficiency to Incidence and Worsened COVID-19 Outcomes

      A recent study in China showed that vitamin D deficiency was among significant risk factors for COVID-19 severity.
      01.11.21

    • Breaking News | Cancer Risk | Consumer Trends | Dairy-Based Ingredients | Healthcare Trends | Medical Nutrition | Proteins, Peptides, Amino Acids | Regulations | Regulatory News
      Physicians Committee Calls on USDA to Retract Latest Dietary Guidelines for Americans

      Physicians Committee Calls on USDA to Retract Latest Dietary Guidelines for Americans

      The non-profit health organization believes research linking animal products to cancer risk was overlooked.
      01.08.21

    • Breaking News | Diabetes & Blood Sugar Management | Dietary Supplements | Healthcare Trends | Medical Nutrition | Probiotics & Prebiotics | Research | Research News | Weight Management/Weight Loss
      Researchers Identify Microbes Which Could Benefit Type 2 Diabetes

      Researchers Identify Microbes Which Could Benefit Type 2 Diabetes

      Certain strains are linked to lower BMI, while others appear to beneficially modulate glucose response, lipids, and mitochondrial health in the liver.
      01.08.21

    Trending
    • Nutrition Industry Reacts To 2020-2025 Dietary Guidelines For Americans
    • Preliminary Study Suggests Link Between Omega-3s And Lower COVID-19 Death Rates
    • NOW Raises Additional Concerns About Supplements Available On Amazon
    • High-Protein Meal Replacement Improves Exercise Metabolism Compared To Standard Breakfast
    • Seraphina Therapeutics Formulates Dairy Ingredient For Cellular Health
    Breaking News
    • Ingredient Manufacturers Discuss the E-Sports Market
    • Euromonitor Names Top Ten Trends for 2021
    • Study Highlights Differences Between EPA's and DHA's Effect on Sleep
    • BGG Obtains U.S. Patent on AstaZine Natural Astaxanthin for Heart Function During Exercise
    • Qualitas Health/iwi Raises $10 Million in Investment Round
    View Breaking News >
    CURRENT ISSUE

    Jan/Feb 2021

    • The Value of Vitamin D Testing
    • A Glance At The Eye Health Market
    • Citrus Support for the Blood Glucose-Immune System Connection
    • Modern Snacking: Where Health & Indulgence Converge
    • More Than Just A Trend: Supplements Embedded in Consumer Health Regimens
    • A Growing Need for Mineral Supplementation
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Ingredient Manufacturers Discuss the E-Sports Market
    Euromonitor Names Top Ten Trends for 2021
    Study Highlights Differences Between EPA's and DHA's Effect on Sleep
    Coatings World

    Latest Breaking News From Coatings World

    IGL Coatings Launches Graphene Reinforced Dual System Ceramic Coating
    Miller Paint Declares Simple Serenity its 2021 Color of the Year
    TAUBMANS Paint by PPG Releases ‘Chromatic Joy’ Palettes
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Eitan Medical Receives FDA Clearance for Sapphire Infusion System
    Researchers Successfully ‘Fine Tune’ New Thermoplastic Biomaterial
    RSIP Vision Announces Versatile Medical Image Segmentation Tool
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Global Biosciences Co. Selects ValGenesis VLMS
    Eisai Appoints Chief Clinical Officer of Oncology Biz
    Nexelis Acquires GSK Vax Lab in Marburg
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Top Beauty Brands in the World—And Most Loved Fragrances
    P&G Reports Q2 Results
    A Lacquering Technique Makes Very Good Girl by Carolina Herrera Shine
    Happi

    Latest Breaking News From Happi

    Flow Launches Collagen Waters
    Associations Congratulate Biden & Harris
    David Stanko Joins JPMS
    Ink World

    Latest Breaking News From Ink World

    Morancé Soudure France Adds Comexi F2 MC 10-color Flexo Press
    THIMM Group Installs 1st Koenig & Bauer CorruFLEX
    Cowan Graphics Adds Fujifilm Inca OnsetX3 HS
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Domino grows installation and service teams
    ABG keeps pace with demand with recruitment drive
    Acucote expands FSC-certified portfolio
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    First Quality Launches Incognito by Prevail
    Essity Launches Reusable Underwear Product
    Honeywell Delivered 225 Million Masks in December
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    DJO Acquires Trilliant Surgical
    FDA Breakthrough Device Designation Granted to Spiderwort's Spinal Cord Technology
    Bioventus Appoints SVP of Operations
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    UDC Subsidiary Adesis' Website Wins 2020 MarCom Platinum Award
    Roadsimple Modernizes Warehouse Ops with Zebra Technologies
    Graphene Flagship Launches Redesigned Website

    Copyright © 2021 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login