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    Breaking News

    ABC Updates Monograph on Scientific and Clinical Research on Pycnogenol

    Document describes scientific data supporting various uses of the French maritime pine bark extract.

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    02.08.19
    The non-profit American Botanical Council (ABC) has published an updated ingredient-specific monograph that summarizes selected scientific and clinical studies of Pycnogenol, a patented dietary ingredient derived from French maritime pine bark (Pinus pinastersubsp. atlantica, Pinaceae). ABC’s first monograph on Pycnogenol was published in 2010.  
     
    The revised monograph describes a total of 63 human clinical trials on Pycnogenol—46 more than were included in the original monograph. The studies evaluate the proprietary extract’s potential benefits for numerous health conditions, including chronic venous insufficiency (improper leg vein function), thrombosis (formation or presence of clots in blood vessels), type 2 diabetes, and hypertension.
     
    The evidence from the selected scientific and clinical trials suggests that Pycnogenol may have a wide range of potential applications, including the ability to improve blood sugar control in patients with type 2 diabetes and improve endothelial function (the ability of blood vessels to widen through relaxation of the muscular wall of the vessels). Current clinical trial data suggest that Pycnogenol may also help decrease edema formation (swelling) in the lower legs, benefit children with attention deficit hyperactivity disorder (ADHD), be a useful adjunct therapy for patients with asthma, reduce pain associated with menstrual disorders, and improve subjective symptoms of osteoarthritis in the knee. 
     
    “Few proprietary botanical extracts have been subjected to human clinical trials in such a wide range of human health conditions,” said Mark Blumenthal, founder and executive director of ABC. “We acknowledge Horphag Research, the producer of Pycnogenol, for its strong commitment to clinical research on its leading ingredient.”
     
    Horphag Research of Geneva, Switzerland invests about $1.5 million annually in new scientific and clinical research on the special extract.
     
    According to Victor Ferrari, CEO of Horphag Research, “The new ABC monograph is the most comprehensive technical document on Pycnogenol to date. It will help tremendously in educating the industry and scientific audience and sets the foundation for all future developments and research to come. Horphag Research is committed to continue the path of evidence-based science and innovation.”

    The monograph is published in three parts: a clinical overview (i.e., executive summary) containing condensed information from the monograph, a consumer/patient information sheet consisting of essential information for consumer education about the responsible use of the product, and the full monograph that describes scientific and clinical research on Pycnogenol. Each of these elements is accessible separately on the ABC website.
     
    The full monograph contains an overview of Pycnogenol’s production and chemistry, uses of the product, dosage information, summaries of the product’s pharmacology and mechanisms of action, safety data, and summaries of selected clinical trials. A 13-page table includes synopses of the clinical trials profiled within the monograph’s text, plus summaries of several additional studies. The monograph also includes patent information and describes how Pycnogenol is regulated in 10 countries and regions around the world.
     
    Pycnogenol’s manufacturer Horphag Research has extensively studied the extract over the past 49 years to assure the safety and efficacy of Pycnogenol as an ingredient in dietary supplements and conventional foods. According to the company, more than 100 clinical trials and a total of over 400 scientific studies and review articles have been published on the extract. Horphag Research earned the Frost & Sullivan North American Health Ingredients Excellence in Research of the Year Award for 2008, and ABC presented the company with the Varro E. Tyler Commercial Investment in Phytomedicinal Research Award in 2012.
     
    ABC’s ingredient-specific monograph on Pycnogenol was written by toxicologist Heather S. Oliff, PhD, and it was formally peer reviewed by scientific and medical experts for its accuracy. “The Pycnogenol monograph is a useful compendium on Pycnogenol because it is a very thorough and unbiased review of the scientific literature,” she said.
     
    ABC emphasizes that the publication of the Pycnogenol monograph is not an endorsement or recommendation of the ingredient or the manufacturer. “ABC has had a long history of documenting the specific herbal products and ingredients that have been clinically tested,” said Blumenthal. “As part of our non-profit research and educational mission, we believe it is in the public interest to identify human clinical research conducted on natural plant-based products and ingredients which the scientific literature suggests are safe and beneficial.” 
     
    ABC’s Pycnogenol monograph is the fifth in a series of product- or ingredient-specific monographs that the organization has initiated. It was produced under an educational grant from Horphag Research to ABC. The organization has plans to produce additional monographs concerning specific researched commercial products and ingredients.
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