06.13.17
ChromaDex Corp., Irvine, CA, has signed an exclusive patent license and research agreement with The Scripps Research Institute (TSRI), gaining access to groundbreaking, pre-clinical discoveries by Dr. Brunie Felding.
Dr. Felding’s patented discoveries include the enhancement of NAD+ metabolism through treatment with NAD+ precursors to potentiate the effects of endocrine therapy in breast cancer, inhibit resistance of breast cancer cells to endocrine therapy, and re-instate sensitivity in breast cancer cells that are unresponsive to endocrine treatments such as Tamoxifen. The research agreement will build upon the previous material transfer agreement, and if successful, will yield the data and tools required for the development of a clinical trial evaluating a novel combination therapy consisting of nicotinamide riboside (NR) and endocrine therapy in the treatment of breast cancer.
This acquisition brings the total number of patents and patents pending relating to nicotinamide riboside, owned or exclusively licensed by ChromaDex, to 16.
ChromaDex Founder and CEO, Frank Jaksch, stated, “TSRI was one of the first institutions we signed a material transfer agreement with on NR back in 2013. It’s great to see that TSRI’s discoveries have now sparked a collaborative partnership that could lead to another drug application.”
ChromaDex Scientific Affairs Director Amy Boileau commented, “Though the research is still early stage, the findings by Dr. Felding and her team are remarkable. We are thrilled to expand our partnership with TSRI and continue advancing research that holds great promise for improved treatment of breast cancer.”
The TSRI team is equally pleased to build upon the existing partnership. “Our research indicates that normalizing tumor cell metabolism could very efficiently enhance cancer therapy,” said Dr. Felding. “The planned studies may identify a novel way to enhance treatment responses and improve the quality of life for cancer patients.”
This new research program adds to a robust lineup of over 100 collaborative research studies with leading universities and research institutions, representing an estimated $50 million in NR research.
Dr. Felding’s patented discoveries include the enhancement of NAD+ metabolism through treatment with NAD+ precursors to potentiate the effects of endocrine therapy in breast cancer, inhibit resistance of breast cancer cells to endocrine therapy, and re-instate sensitivity in breast cancer cells that are unresponsive to endocrine treatments such as Tamoxifen. The research agreement will build upon the previous material transfer agreement, and if successful, will yield the data and tools required for the development of a clinical trial evaluating a novel combination therapy consisting of nicotinamide riboside (NR) and endocrine therapy in the treatment of breast cancer.
This acquisition brings the total number of patents and patents pending relating to nicotinamide riboside, owned or exclusively licensed by ChromaDex, to 16.
ChromaDex Founder and CEO, Frank Jaksch, stated, “TSRI was one of the first institutions we signed a material transfer agreement with on NR back in 2013. It’s great to see that TSRI’s discoveries have now sparked a collaborative partnership that could lead to another drug application.”
ChromaDex Scientific Affairs Director Amy Boileau commented, “Though the research is still early stage, the findings by Dr. Felding and her team are remarkable. We are thrilled to expand our partnership with TSRI and continue advancing research that holds great promise for improved treatment of breast cancer.”
The TSRI team is equally pleased to build upon the existing partnership. “Our research indicates that normalizing tumor cell metabolism could very efficiently enhance cancer therapy,” said Dr. Felding. “The planned studies may identify a novel way to enhance treatment responses and improve the quality of life for cancer patients.”
This new research program adds to a robust lineup of over 100 collaborative research studies with leading universities and research institutions, representing an estimated $50 million in NR research.
