Source: Nutr Metab, October 15, 2011;8(1):71.
Research: Seventy-nine healthy sedentary post-menopausal women aged 58-78 years were randomized to one of four groups: exercise + supplement (E+S, n=21), exercise (E, n=20), supplement (S, n=20), and control (Con, n=18). The subjects in the E+S and E groups performed aerobic exercise training (walking and jogging) up to 65% of HRmax, three times a week for 24 weeks. Subjects in the E+S and S groups consumed 1000 mg a day of N-3 for 24 weeks. The lumbar spine (L2-L4) and femoral neck BMD, serum tumor necrosis factor (TNF) alpha, interleukin (IL) 6, prostaglandin (PG) E2, estrogen, osteocalcin, 1,25-dihydroxyvitamin D3 (1,25 Vit D), C-telopeptide (CTX), parathyroid hormone (PTH) and calcitonin (CT) were measured at baseline, and at the end of weeks 12 and 24.
Results: Serum estrogen, osteocalcin, 1,25 Vit D, CT, L2-L4 and femoral neck BMD measures increased and the serum CTX, PTH, TNF-alpha, IL-6 and PGE2 decreased in E+S group after the 24 week intervention but not in the E or S intervention groups. L2-L4 and femoral neck BMD, estrogen, osteocalcin and CT were negatively correlated with TNF-alpha and PGE2. PTH and CT were correlated positively and negatively with IL-6, respectively. According to researchers, this study demonstrates that long-term aerobic exercise training plus N-3 supplementation have a synergistic effect in attenuating inflammation and augmenting BMD in post-menopausal osteoporosis.