In collaboration with the Jordan Valley Innovation Center within Missouri State University, the scientists evaluated three different hydrolyzates of eggshell membrane (fermentation, enzymatic, or chemical) in cell cultures of two different types of human immune cells. All three hydrolyzates were found to activate the gene transcription factor NF-kB, although the chemical hydrolyzate was about 10-fold less effective versus the fermentation and enzymatic hydrolyzates. NF-kB plays a fundamental role in the functioning of the immune system and occurs very early in the inflammatory cascade. Dysregulation of NF-kB has been implicated in the development of a number of classical inflammatory diseases such as rheumatoid arthritis, asthma, and inflammatory bowel disease. Interestingly, NF-kB dysregulation has also been associated with diseases such as diabetes, Alzheimer’s Disease, and multiple sclerosis which are not traditionally thought of as inflammatory in nature.
“It’s always rewarding to gain insight into the observed efficacy of one of our ingredients through fundamental research, particularly when this leads to the potential for new intellectual property,” commented Dr. Kevin J. Ruff, Director of Scientific & Regulatory Affairs for ESM Technologies, the manufacturer of NEM. The results of these studies were published in the February issue of the Journal of Inflammation Research (DOI: http://dx.doi.org/10.2147/JIR.S78118).
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