• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    A Kingdom of Their Own: Fungi Shine While Mushrooms Emerge as Market Stars

    The Pet Health Boom: Supplement Growth Set to Build on Rapid Expansion

    (Re)Open for Business: China’s Strong Demand for Natural Products Spells Opportunity for U.S. Brands

    Review Finds No Causative Connection Between Dietary Supplements and Eating Disorders

    KA! Empathogenics: Creating Calm and Connectedness with Inspiration from Nature
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Glossary
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Stefan Pasiakos, PhD, Selected to Lead NIH Office of Dietary Supplements

    Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing

    BGG Receives Patent for Saw Palmetto ID Method

    Premium Label & Packaging Solutions Receives Safe Quality Food (SQF) Certification

    Inulinase Enzymes May Benefit Gut Symptoms of FODMAP Digestion
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    A Kingdom of Their Own: Fungi Shine While Mushrooms Emerge as Market Stars

    Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing

    BGG Receives Patent for Saw Palmetto ID Method

    ‘Uniquely Unbound’: Releasing the Potential, and Genius, of Walnuts

    Inulinase Enzymes May Benefit Gut Symptoms of FODMAP Digestion
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Stefan Pasiakos, PhD, Selected to Lead NIH Office of Dietary Supplements

    A Kingdom of Their Own: Fungi Shine While Mushrooms Emerge as Market Stars

    Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing

    BGG Receives Patent for Saw Palmetto ID Method

    The Pet Health Boom: Supplement Growth Set to Build on Rapid Expansion
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    A Kingdom of Their Own: Fungi Shine While Mushrooms Emerge as Market Stars

    ‘Uniquely Unbound’: Releasing the Potential, and Genius, of Walnuts

    Inulinase Enzymes May Benefit Gut Symptoms of FODMAP Digestion

    Gaming and Esports Health Concerns

    Bioiberica’s DAOgest Authorized as Novel Food ingredient in EU
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Gencor

    Applied Food Sciences, Inc.

    KLK OLEO

    Bioenergy Life Science, Inc. (BLS)

    American FlexPack
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Gencor

    Applied Food Sciences, Inc.

    KLK OLEO

    Bioenergy Life Science, Inc. (BLS)

    American FlexPack
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Online Exclusives

    SRW Laboratories Debuts Line of Supplements Targeting Cellular Health

    The range of three products features hobamine, a novel ingredient tied to DNA protection and antioxidant activity, alongside several other emerging ingredients.

    SRW Laboratories Debuts Line of Supplements Targeting Cellular Health
    By Mike Montemarano, Associate Editor 11.18.21
    The structure and function of cells, as measured by DNA, free radical signaling, metabolism at the mitochondrial level, telomere length, and other areas, is a promising frontier for researchers in the dietary supplements space. Clinical studies are seeking to understand how food components can affect biological age, and perhaps, even turn back some of the biological clocks – biomarkers tied to age-related health conditions.  
     
    The newly-founded supplement brand SRW Laboratories (short for Science Research Wellness), led by founder Greg Macpherson, recently launched its first full line of targeted cellular health supplements alongside a team of scientists which includes researcher Dr. Naji Abumrad. The company discussed how its Cellular System portfolio of three products target the effects of aging.
     
    Macpherson, a pharmacist, biotechnologist, and cellular health expert, has worked to create a brand which can encompass various nutritional areas which can have an effect on aging, which is the premise for his newly-released book “Harnessing the Nine Hallmarks of Aging.” SRW was then founded on the premise of helping people to succeed at aging well based on a host of cellular health targets which have been identified by contemporary research.
     
    “Up until now we’ve aged fairly well with basic lifestyle management and a little luck,” Macpherson said. “Today, we have the precise tools to take it to another level – the cellular level. Using the nine hallmarks of aging, or identified causes of aging, we can literally reprogram our cells to function at a much younger biological age than our current chronological age. No other generation has had this technology available to them.”
     
    How Well Are Your Cells?
    The product line features a relatively novel ingredient known as hobamine (2-HOBA), an antioxidant found in the highest natural concentrations in Himalayan Tartary Buckwheat. 2-HOBA was discovered by Vanderbilt University scientists through research spearheaded by Abumrad, who is now an SRW team member. To date, only one other supplement on the market contains this distinguished antioxidant, according to SRW.
     
    “The discovery of Hobamine (2-hydroxy-benzyl amine; aka 2-HOBA) and its effective beneficial effects necessitates a complete understanding of the role that lipid aldehydes play in the development of various disease processes,” Abumrad said. “Several investigators, dating back to the mid-1980s have discovered the formation of various free radicals, the most notorious of which are called Isolevuglandins (IsoLGs) that rapidly react with various proteins and nucleic acids causing damage to many cellular components in the body.”
     
    Investigators found that IsoLGs accumulate and cause damage in a wide variety of disease states, Abumrad said, including neurodegenerative diseases. “The same investigators sought therapeutic strategies to arrest the damage caused by IsoLGs,” he added, and while strategies to target the formation of these free radicals failed, the investigators developed an alternative successful strategy to develop small molecules that can react more rapidly and trap the IsoLGs formed, thus preventing cellular damage.
     
    “In the early 2000s investigators at Vanderbilt developed 2-HOBA (Hobamine) and found it to be the most effective at blocking the formation of IsoLG protein adducts in platelets and other cells,” Abumrad said. “The seminal papers were published in 2004 (Amarnath, et al.) and 2006 (Davies, et al.). Soon thereafter, it was found that hobamine was a natural component of buckwheat, with the highest concentration found in Tartary buckwheat. Synthesis of hobamine led to testing in arresting the development and occasional reversal of many of the biochemical and molecular abnormalities found in chronic diseases mentioned above. Metabolic Technologies, Inc. obtained the worldwide rights for hobamine and carried out and established safety, tolerability, and pharmacokinetic studies for hobamine in animals and later in humans, both in young and older adults and these were recently published (2019-2021). These studies led the way for obtaining GRAS (generally recognized as safe) affirmation for hobamine, and there are several ongoing studies examining the efficacy in various disease states in humans.”
     
    Specific disease states that Abumrad mentioned, for which there is ongoing clinical research being done, include hypertension, arrhythmias, atherosclerosis, obesity, lung injury, cancer, blood disorders (particularly those effecting platelets), chronic kidney disease, eye disease, and several neurodegenerative diseases including Alzheimer’s.
     
    “Hobamine is part of a new class of cellular protectors that researchers have been investigating, known as reactive carbonyl species (RCS) scavengers,” MacPherson added, noting that beyond the challenge of establishing that IsoLGs are more present in disease tissues, establishing causation beyond the correlation, and developing and testing molecules which might target IsoLG activity took significant research investment. “While free radicals cause damage to cellular components they really only light the fuse. The real damage occurs when lipids are oxidized and form reactive carbonyl species. The byproducts of lipid peroxidation are highly reactive isolevuglandins that bond very quickly and irreversibly with critical cell components like proteins and DNA. These isoLG-protein/DNA-adducts interfere with cell function, are immunogenic and in many cases are unable to be broken down and removed from the cell leading to persistent cell damage that accumulates over time.”
     
    In addition to overall diet, intermittent fasting, exercise, stress reduction, and sleep, dietary interventions have also been revealed to potentially support DNA repair mechanisms, and these interventions were the foundation behind the company’s line of products, which includes Cel1 Stability, Cel2 Nourishment, and Cel3 Renewal. The overall age of cells, as determined by DNA testing which reveals how “old” a cell is acting, can be vastly different from what is normally associated with a certain chronological age.
     
    The first supplement, which contains clinically-relevant dosages of hobamine, astragaloside, and rutin, is formulated to support DNA structure and function in the presence of stress factors such as lack of sleep, poor diet, excessive stress, or exposure to UV and pollution. The second supplement, which contains nicotinamide mononucleotide, pterostilbene, and astaxanthin, is designed to serve as a precursor used in mitochondrial metabolism for energy support. The third supplement, an antioxidant-flavonoid blend containing fisetin, apigenin, oleuropein, berberine, and EGCG, is designed to support the “cellular housekeeping process,” or the metabolic processes by which the body clears out and recycles senescent cells that are no longer useful.
     
    Macpherson said that optimal times to begin supplementation with a variety of the active ingredients can vary. An ideal time to being taking hobamine would be in ones twenties, he said. “Just like we apply sunscreen to our faces over the course of a lifetime to slow the effect of chronic UV exposure on our appearance, supplementing with hobamine during the course of a lifetime helps to slow the irreversible effects of free radical damage across all tissue types. NAD is a critical enzyme involved in over 500 cellular processes. NAD levels decline precipitously from our late 30s and beyond. The perfect time to start supplementing with NMN is in your 40s, or earlier, if you have a condition associated with mitochondrial dysfunction or have high levels of oxidative stress putting pressure on DNA structure and function. For those in their 50s and beyond, it is becoming increasingly clear that the addition of natural senolytics like fisetin into their supplement regime will lower the inflammatory burden of senescent cells that accumulate with age and will also support a healthy inflammatory response to infections.”
     
    Related Searches
    • Delivery & Dosage Technologies
    • Healthy Aging
    • Antioxidants
    • Inflammation
    Related Knowledge Center
    • Delivery & Dosage Technologies
    • Dietary Supplements
    • Antioxidants
    • Healthy Aging
    • Inflammation
    • Energy
    • Research
    • Immune Function
    • Medical Nutrition
    Suggested For You
    The Pet Health Boom: Supplement Growth Set to Build on Rapid Expansion The Pet Health Boom: Supplement Growth Set to Build on Rapid Expansion
    ‘Uniquely Unbound’: Releasing the Potential, and Genius, of Walnuts ‘Uniquely Unbound’: Releasing the Potential, and Genius, of Walnuts
    (Re)Open for Business: China’s Strong Demand for Natural Products Spells Opportunity for U.S. Brands (Re)Open for Business: China’s Strong Demand for Natural Products Spells Opportunity for U.S. Brands
    Verdure Sciences’ Boswellia Ingredient Receives USP Verification Verdure Sciences’ Boswellia Ingredient Receives USP Verification
    Review Finds No Causative Connection Between Dietary Supplements and Eating Disorders Review Finds No Causative Connection Between Dietary Supplements and Eating Disorders
    KA! Empathogenics: Creating Calm and Connectedness with Inspiration from Nature KA! Empathogenics: Creating Calm and Connectedness with Inspiration from Nature
    MartinBauer Launches Line of Floral Ingredients for Beverages MartinBauer Launches Line of Floral Ingredients for Beverages
    Nature’s Bounty Reveals Women’s Health Supplements for Hair Growth and Weight Management Nature’s Bounty Reveals Women’s Health Supplements for Hair Growth and Weight Management
    CBD, Other Cannabinoids Well-Tolerated Among Healthy Dogs: Study Commissioned by NASC CBD, Other Cannabinoids Well-Tolerated Among Healthy Dogs: Study Commissioned by NASC
    Clinical Health Educator - Hormone Health - Barrington, IL Clinical Health Educator - Hormone Health - Barrington, IL
    Sempera Organics Launches Six New Mushroom Ingredients Sempera Organics Launches Six New Mushroom Ingredients
    CRN Petitions FDA to Change Course on CRN Petitions FDA to Change Course on 'Drug Preclusion'
    Trends in the Nutraceuticals Market Trends in the Nutraceuticals Market
    Nature’s Way Launches Brain Fuel, a Cognitive Support Supplement Nature’s Way Launches Brain Fuel, a Cognitive Support Supplement
    Novozymes OneHealth to Give Presentations on Spores, Vitamin K2, and Psychobiotics Novozymes OneHealth to Give Presentations on Spores, Vitamin K2, and Psychobiotics

    Related Features

    • Consumer Trends | Delivery & Dosage Technologies | Dietary Supplements | Pet Nutraceuticals | Quality & Safety | Regulations | Research | Testing
      The Pet Health Boom: Supplement Growth Set to Build on Rapid Expansion

      The Pet Health Boom: Supplement Growth Set to Build on Rapid Expansion

      The pandemic compelled many people to add a furry friend to their family, and their spending habits demonstrate a dedication to health.
      By Sean Moloughney, Editor 05.30.23

    • Cognitive Function | Delivery & Dosage Technologies | Fatty Acids | Nutrition Bars & Snacks | Omega-3s
      ‘Uniquely Unbound’: Releasing the Potential, and Genius, of Walnuts

      ‘Uniquely Unbound’: Releasing the Potential, and Genius, of Walnuts

      Rikki Bhatti, co-founder of Unbound Snacks, is a third-generation farmer intent on giving walnuts their (relative) time in the limelight.
      By Sheldon Baker 05.26.23

    • Dietary Supplements | Natural/Organic | Quality & Safety | World Markets
      (Re)Open for Business: China’s Strong Demand for Natural Products Spells Opportunity for U.S. Brands

      (Re)Open for Business: China’s Strong Demand for Natural Products Spells Opportunity for U.S. Brands

      The United Natural Products Alliance (UNPA) has established an e-channel for companies to sell supplements to China despite trade uncertainties.
      By Sean Moloughney, Editor 05.24.23


    • Breaking News | Certifications, Approvals & Patents | Herbs & Botanicals | Quality & Safety | Supplier News | Testing
      Verdure Sciences’ Boswellia Ingredient Receives USP Verification

      Verdure Sciences’ Boswellia Ingredient Receives USP Verification

      WokVel Boswellia serrata extract received the USP seal after ingredient testing, manufacturing audits, and documentation review.
      05.23.23

    • Dietary Supplements | Healthcare Trends | Research | Sports Nutrition | Weight Management/Weight Loss
      Review Finds No Causative Connection Between Dietary Supplements and Eating Disorders

      Review Finds No Causative Connection Between Dietary Supplements and Eating Disorders

      Studies attempting to link supplements to ED are inadequately designed, and often conflate drugs and dietary supplements.
      By Mike Montemarano, Associate Editor 05.23.23

    Loading, Please Wait..
    Trending
    • Soviets Took Probiotics To The Next Level
    Breaking News
    • Stefan Pasiakos, PhD, Selected to Lead NIH Office of Dietary Supplements
    • Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing
    • BGG Receives Patent for Saw Palmetto ID Method
    • Premium Label & Packaging Solutions Receives Safe Quality Food (SQF) Certification
    • Inulinase Enzymes May Benefit Gut Symptoms of FODMAP Digestion
    View Breaking News >
    CURRENT ISSUE

    May 2023

    • Cellular Aging and Longevity: Ingredients for a New Age of Health
    • Addressing the Plastic-Packaging Problem: Getting to Zero-Waste with Zero Compromise
    • Moms Raise the Bar for Kids Supplements
    • Building on Steps to Improve Children’s Health Around the World
    • FDA Remains Focused on Modernizing DSHEA
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Stefan Pasiakos, PhD, Selected to Lead NIH Office of Dietary Supplements
    Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing
    BGG Receives Patent for Saw Palmetto ID Method
    Coatings World

    Latest Breaking News From Coatings World

    120 Years HOFFMANN MINERAL - Success Through Innovation and Responsibility
    New ‘Invisible’ Coating Against Bacteria
    Sherwin-Williams Launches Ultra-High-Solids Epoxy
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Freudenberg Medical Implements Virtual Reality Training for Employees
    Siemens Healthineers and CommonSpirit Health Acquire Block Imaging
    Japanese Regulators Approve EDAP's ExactVu Micro-Ultrasound
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Getinge Acquires High Purity New England
    3M Invests $146M in Biopharma Filtration Technology
    Impact Therapeutics, Eikon Partner to Develop PARP1 Selective Inhibitors
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Kiehl’s Celebrates Pride by Supporting The Trevor Project
    L’Oréal & UNESCO Announce 2023 Laureates of the For Women in Science International Awards
    Sky Organics Earns B Corp Certification
    Happi

    Latest Breaking News From Happi

    P&G Patents Laundry Detergent with EO/PO/EO Triblock Copolymer, Lipase
    Gojo Patents Non-Antimicrobial Cleansing Composition
    Beauty Pie Taps Kevin Cornils as CEO
    Ink World

    Latest Breaking News From Ink World

    Graphco and Printing & Finishing Solutions Participate at IPMA
    IMCD Strengthens North America Technical Capabilities
    Arkema Partners with Habitat for Humanity Philadelphia
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    ACTEGA teams with Makro Labelling to advance Signite technology
    Constantia Flexibles and SB Packagings commence joint venture
    Inland donates new VersaStudio printer to local high school
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    What You’re Reading on Nonwovens-Industry.com
    Biodiapers Signs Agreement with Sicam
    Sinaatec Uses Two A.Celli End-Of-Line Solutions
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Artelon Closes $20M Series B Funding
    Orthofix Unveils Seven-Year Outcome Data for M6-C Artificial Cervical Disc
    Enrollment Completed in Anika Therapeutics' Hyalofast Study
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Arkema Collaborates with Habitat for Humanity Philadelphia
    Vitesco Technologies, onsemi Sign SiC Long-Term Supply Agreement
    Ambiq Receives 2023 Bronze Stevie Award

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login