• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Nutraceuticals for Men: Muscle Health and Performance Nutrition

    Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions

    Getting an Edge in Esports: Meeting the Health Needs of Competitive Gamers

    Beyond CBD: Cannabis Compounds Warrant Recognition and More Research

    Leveling Out the Energy Segment for Mainstream, and Rethinking Caffeine
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    FDA Issues Draft Guidance on NDI Enforcement Discretion

    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Sabinsa Corporation

    Aiya America, Inc. (Aiya Matcha)

    Ecuadorian Rainforest

    KLK OLEO

    Verdure Sciences
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Sabinsa Corporation

    Aiya America, Inc. (Aiya Matcha)

    Ecuadorian Rainforest

    KLK OLEO

    Verdure Sciences
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Online Exclusives

    Layn Launching Standardized Sophora Japonica Extract to Target Inflammation, Oxidative Stress

    An in vitro study showed SophorOx significantly inhibited six pro-inflammatory and reactive molecules linked to oxidative stress.

    Layn Launching Standardized Sophora Japonica Extract to Target Inflammation, Oxidative Stress
    Layn harvests the buds of the Sophora japonica plant before they bloom, when they are most abundant in polyphenols.
    Related CONTENT
    • Cranberry Consumption Linked to Memory and Neurological Function Improvements
    • Experts Debate Role of Supplements in Improving Public Health in EU
    • Walgreen’s Brand Vitamins and Supplements First to Carry UL Verified Mark
    • Indena Spotlights ‘Fabulous Four’ Ingredients
    • Quality Testing of CoQ10 and Quercetin Brands Sold on Amazon Finds Continued Failure
    By Mike Montemarano, Associate Editor 09.13.21
    Layn Natural Ingredients is launching a new Sophora japonica extract, SophorOx, which is standardized to support a healthy inflammatory response thanks to its standardized levels of polyphenols.
     
    Specifically, the extract is standardized to 90% flavonoids, including quercetin, rutin, isorhamnetin, kaempferol, genistin, and genistein, according to Jim Roza, Layn’s chief scientific officer.

    “Stevia has certainly been Layn’s claim to fame, but we’re much more than that. One of our core competencies is polyphenols, and when you count the number of teas and botanical extracts that we have, we have over 100 products,” Roza said. “We’re one of the global leaders in Sophora japonica, with about 25% of its global supply, from which many of our polyphenols are derived. We’ve studied polyphenols for a long time, and know a great deal about the benefits that these polyphenols can provide regarding their antioxidant and anti-inflammatory properties.”
     
    “With the pandemic, and knowing that people who are in poor health quite often suffer because of the fact that there’s too much oxidative stress occurring in their body, as well as chronic inflammation, we were led to look at many of our different polyphenols,” Roza continued. “We know how each one works individually, and decided to look at a formulation of Sophora japonica extracted into a proprietary form, and test it for its antioxidant and anti-inflammatory properties, which was the impetus for us to move forward with an in vitro study to show proof of concept.”
      
    Currently, SophorOx is supported by a proof-of-concept in vitro study as well as an in vivo animal study, both conducted with contract researcher Vedic Lifesciences, which concluded that the extract, at doses equivalent to 500 mg per day for an average adult, significantly reduced several markers of oxidative stress in exercised mice compared to placebo. Both studies are currently slated for publication in the near future, according to Layn.
     
    Specifically, SophorOx was shown in the in vitro study to significantly inhibit six pro-inflammatory and reactive molecules linked to oxidative stress, including: 8-Isoprostane, a biomarker of lipid peroxidation; MDA, which is derived from PUFA peroxidation in cells; 8-OHdG, a marker of DNA damage; C-reactive protein, a common marker of systemic inflammation; Interleukin-1 beta, a marker of pro-inflammatory cytokine production; and Interleukin-6, a pro-inflammatory cytokine produced in immune responses.
     
    Additionally, the company is seeking to conduct a human clinical trial, the design for which is still under review. “Of course, we’d like to take things beyond proof-of-concept and efficacy in lab animals,” said Roza. “I’m in the process of working with a life science company to develop a human study involving mildly obese individuals, who are known to have higher amounts of visceral fat. They typically experience higher levels of oxidative stress and inflammation and would be a good model to test this ingredient in a human clinical study.”
     
    As a botanical ingredient, plenty of expertise regarding the harvest conditions of Sophora japonica is necessary to achieve the standardization needed for clinical efficacy, Roza said. “We take the buds of the plant before they bloom when they are most abundant in polyphenols and these flavonoids, and that’s when we do the extraction. This ingredient is naturally-occurring and is naturally-sourced,” Roza said.
     
    Consumer Needs and Delivery Platforms
    SophorOx, Roza said, has plenty of versatility and can be featured in a range of delivery formats.
     
    “Healthy agers want to be able to live life to the fullest, and could really benefit from this ingredient as a standalone or alongside other polyphenols, vitamins, and minerals,” he said. “I think it’s also an important ingredient for millennials, who are aware that the population is aging and that they might want safeguards. Another group would be athletes – whether you’re a weekend warrior or someone who is a runner or a weightlifter.”
     
    While regular exercise is important, it does create oxidative stress and inflammation, Roza said. “SophorOx could work well as a post-workout ingredient. Gamers, workers, and students are also increasingly exposed to high levels of blue light, and antioxidants are very important to mitigating its effects. Lastly, I’d say that this ingredient could be useful for people with allergies. Quercetin, which is a major component of the ingredient, has been shown to be helpful in allergic responses. We’re generally positioning this product as one that is helpful to maintain a healthy inflammatory response. Inflammation raises a red flag for many people when it’s talked about, and many people see any inflammation as bad which is not the case. It becomes problematic when the response goes awry and becomes chronic.”
     
    SophorOx can be applied to powders, capsules, and softgels, Roza said, and can be emulsified in order to appear in bars, beverages, gummies, and potentially topical dermal applications.


    Mike Montemarano has been the Associate Editor of Nutraceuticals World since February 2020. He can be reached at MMontemarano@RodmanMedia.com.
    Related Searches
    • Delivery & Dosage Technologies
    • Herbs & Botanicals
    • Inflammation
    • Antioxidants
    Related Knowledge Center
    • Research
    • Herbs & Botanicals
    • Inflammation
    Suggested For You
    Cranberry Consumption Linked to Memory and Neurological Function Improvements Cranberry Consumption Linked to Memory and Neurological Function Improvements
    Experts Debate Role of Supplements in Improving Public Health in EU Experts Debate Role of Supplements in Improving Public Health in EU
    Walgreen’s Brand Vitamins and Supplements First to Carry UL Verified Mark Walgreen’s Brand Vitamins and Supplements First to Carry UL Verified Mark
    Indena Spotlights ‘Fabulous Four’ Ingredients Indena Spotlights ‘Fabulous Four’ Ingredients
    Quality Testing of CoQ10 and Quercetin Brands Sold on Amazon Finds Continued Failure Quality Testing of CoQ10 and Quercetin Brands Sold on Amazon Finds Continued Failure
    Authenticating Ginkgo Biloba Leaf Extract: Lab Guidance Document Reviews Analytical Methods Authenticating Ginkgo Biloba Leaf Extract: Lab Guidance Document Reviews Analytical Methods
    Supplement Formulations That Win In Wellness Supplement Formulations That Win In Wellness
    HP Ingredients and H&AD to Showcase Ingredients at Vitafoods Europe HP Ingredients and H&AD to Showcase Ingredients at Vitafoods Europe
    Nutraceuticals for Men: Muscle Health and Performance Nutrition Nutraceuticals for Men: Muscle Health and Performance Nutrition
    Fullscript Drives Consolidation While Eyeing Inroads to Conventional Care Fullscript Drives Consolidation While Eyeing Inroads to Conventional Care
    James Roza of Layn Natural Ingredients: Driving the Science and Botanical Innovation James Roza of Layn Natural Ingredients: Driving the Science and Botanical Innovation
    NPA Letter Spells Out Perceived Failings of Proposed Dietary Supplement Listing Act NPA Letter Spells Out Perceived Failings of Proposed Dietary Supplement Listing Act
    Dietary Supplement Listing Bill Introduced in Senate Dietary Supplement Listing Bill Introduced in Senate
    NGS Launches Healthy Heights KidzProtein Nutritional Shakes NGS Launches Healthy Heights KidzProtein Nutritional Shakes
    Bonafide Acquires Patented, Enhanced SAM-e Formulation Bonafide Acquires Patented, Enhanced SAM-e Formulation

    Related Content

    • Antioxidants | Breaking News | Cognitive Function | Herbs & Botanicals | Medical Nutrition | Research News
      Cranberry Consumption Linked to Memory and Neurological Function Improvements

      Cranberry Consumption Linked to Memory and Neurological Function Improvements

      The vascular health benefits of cranberries may have a role to play in neurological improvements, according to the authors.
      05.19.22

    • Dietary Supplements | Healthy Aging | Regulations | World Markets
      Experts Debate Role of Supplements in Improving Public Health in EU

      Experts Debate Role of Supplements in Improving Public Health in EU

      At a panel discussion supported by Food Supplements Europe, stakeholders discussed regulation, bridging nutrient gaps, nutrition literacy, and more.
      By Mike Montemarano, Associate Editor 05.16.22

    • Breaking News | Industry & Market News | Quality & Safety | Testing
      Walgreen’s Brand Vitamins and Supplements First to Carry UL Verified Mark

      Walgreen’s Brand Vitamins and Supplements First to Carry UL Verified Mark

      The certification affirms that product ingredients are as listed on Nutrition Facts and Supplement Facts panels.
      05.16.22


    • Indena Spotlights ‘Fabulous Four’ Ingredients

      Indena Spotlights ‘Fabulous Four’ Ingredients

      Company showcased Anthocran Phytosome (cranberry extract), Relissa (Melissa officinalis), Meriva curcumin, and Berbevis berberine.
      05.12.22

    • Breaking News | Dietary Supplements | Industry & Market News | Quality & Safety | Testing
      Quality Testing of CoQ10 and Quercetin Brands Sold on Amazon Finds Continued Failure

      Quality Testing of CoQ10 and Quercetin Brands Sold on Amazon Finds Continued Failure

      Potency issues are prevalent, and several brands claiming to offer products in vegetarian capsules were found to contain gelatin.
      05.10.22

      Trending
      • Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk In Older Adults | Nutraceuticals World
      • Leaven Essential To Launch Branded Botanical Extracts To Global Markets | Nutraceuticals World
      • Indena’s Meriva Curcumin Supplement May Benefit Kidney Function
      • Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk in Older Adults
      • Test On Hydrolyzed Collagen Shows Resoundingly High Bioavailability | Nutraceuticals World
      Breaking News
      • GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe
      • Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
      • Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission
      • Choline Alone May Improve Maternal DHA Status During Pregnancy
      • Cranberry Consumption Linked to Memory and Neurological Function Improvements
      View Breaking News >
      CURRENT ISSUE

      May 2022

      • Aging in Place: Lifestyle Supplements Science-Based Solutions
      • Getting an Edge in Esports: Meeting Health & Nutrition Needs
      • Nutraceuticals for Men: Muscle Health and Performance Nutrition

      Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
      You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

      • About Us
      • Privacy Policy
      • Terms And Conditions
      • Contact Us

      follow us

      Subscribe
      Nutraceuticals World

      Latest Breaking News From Nutraceuticals World

      GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe
      Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
      Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission
      Coatings World

      Latest Breaking News From Coatings World

      Teknos Receives EcoVadis Gold Medal for Sustainability Performance
      AkzoNobel and Partners Team Up to Hack Carbon Reduction Challenges
      Five PPG Facilities in Ohio Recognized for Sustainability, Health, Safety Practices
      Medical Product Outsourcing

      Latest Breaking News From Medical Product Outsourcing

      Iterative Scopes Expands its Senior Leadership Team
      Viz.ai Raises $100 Million in Series D Funding
      FDA Clears Arterys' AI Mapping and Quantification Tools
      Contract Pharma

      Latest Breaking News From Contract Pharma

      Piramal Pharma Solutions New API Plant in Canada Now Online
      MG America Appoints Claudio Radossi as President
      Catalent Invests $175M to Expand Mfg. Capabilities at Winchester, KY
      Beauty Packaging

      Latest Breaking News From Beauty Packaging

      Authentic Beauty Concept Launches Second-Generation ‘Refill Bar’
      HASK Beauty Enters Exclusive Partnership with Amazon
      Garance Doré Launches Made in France Skincare Line
      Happi

      Latest Breaking News From Happi

      SPF Setting Spray, Lip Contour and Knotless Braids Are Hot Trends: Spate
      Nutrafol Launches Collagen Infusion
      ÄZ Craft Luxury Haircare Products Support All Hairstyles
      Ink World

      Latest Breaking News From Ink World

      Nazdar Celebrates 100 Years with a New Look
      hubergroup Chemicals Exhibits at Paint India for First Time
      Award for Sustainability: Evonik Receives Platinum Rating Again
      Label & Narrow Web

      Latest Breaking News From Label & Narrow Web

      Specialty announces move to new facility
      Mark Andy hosts dealer's open house in Warsaw
      Nazdar celebrates 100th anniversary with refreshed brand identity
      Nonwovens Industry

      Latest Breaking News From Nonwovens Industry

      3M to Expand in Nebraska
      Nicely Offers Nonwoven Slitters, Winders
      'Right' Hygiene Conference to be Held in June
      Orthopedic Design & Technology

      Latest Breaking News From Orthopedic Design & Technology

      FDA Clears Anika Therapeutics' X-Twist Knotless Fixation System
      Paragon 28 Rolls Out TenoTac 2.0 Hammertoe and Soft Tissue Repair
      Cionic Expands Scientific Advisory Board
      Printed Electronics Now

      Latest Breaking News From Printed Electronics Now

      Evonik Launches New Processing Aids for PV Wafer Cutting
      NREL Creates Highest Efficiency 1-Sun Solar Cell
      eMagin Wins People’s Choice Award at Display Week 2022

      Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

      AD BLOCKER DETECTED

      Our website is made possible by displaying online advertisements to our visitors.
      Please consider supporting us by disabling your ad blocker.


      FREE SUBSCRIPTION Already a subscriber? Login