Joanna Cosgrove, Online Editor01.17.13
Rheumatoid arthritis (RA) is a debilitating inflammatory joint disease that affects about 1.3 million adults in the U.S. Though the exact causes of RA are still unknown, the disease triggers an abnormal immune reaction that destroys cartilage and joint linings, and erodes bone. In severe cases, it can also lead to rheumatoid nodules, vasculitis, heart disease, lung disease, anemia and peripheral neuropathy. But a new pilot study published in the Journal of Modern Research in Inflammation by researchers at the Riordan Clinic in Wichita, KA, found that high dose vitamin C delivered intravenously can have a beneficial effect on RA-associated inflammation and pain.
Dr. Nina Mikirova, senior research scientist at the Riordan Clinic, explained that oxidative stress is elevated in RA patients, which implies that reactive oxygen species (ROS) are present as possible mediators of tissue damage. ROS trigger a cascade of events through nuclear factors' activation, which up-regulates gene expression of pro-inflammatory cytokines that med
Dr. Nina Mikirova, senior research scientist at the Riordan Clinic, explained that oxidative stress is elevated in RA patients, which implies that reactive oxygen species (ROS) are present as possible mediators of tissue damage. ROS trigger a cascade of events through nuclear factors' activation, which up-regulates gene expression of pro-inflammatory cytokines that med
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