Diana Food, a specialist in nutritional solutions made from natural ingredients, and nutrition division of German-based Symrise, will launch Cerebelle, a proprietary blend of extracts made from two potent polyphenol-rich fruit—grape and wild blueberry—clinically shown to prevent age-related cognitive decline in healthy older adults at SupplySide West Booth 5081.
The bioavailability of the two components was studied with consistent results showing the combination of the ingredients increased specific flavonoid bioavailability, showing the unique efficacy of Cerebelle.
Grape and wild blueberry extracts contain specific polyphenols with neuroprotective properties. Cerebelle compliments a broad variety of consumer products ranging from traditional dietary supplements to functional foods and beverages.
A clinical study recently published in the Journals of Gerontology by researchers from Canadian-based Institute of Nutrition and Functional Foods (INAF) and the University of Bordeaux in France, showed that six-month supplementation with Cerebelle improved memory in healthy older adults. In a bicentric, double-blind, randomized, placebo-controlled study, 215 healthy subjects from 60 to 70 years of age received for 24 weeks either a placebo or 600 mg/d of Cerebelle. Subjects in both groups performed a series of cognitive tests, designed by CANTAB to assess visiospatial learning, and episodic memory (Paired Associate Learning, PAL), verbal epidsodic and recognition memory (VRM) and working memory (SSP). Supplementation with Cerebelle improved VRM free recall across the whole cohort.
According to Joyce Cascella, consumer health category manager, Diana Food, it was further noted that within the subgroup with advanced cognitive decline at baseline, six-month supplementation with Cerebelle showed improvement of both PAL and VRM. These results suggest that Cerebelle improves verbal memory in healthy elderly people. The study also demonstrated that Cerebelle improves visiospatial memory, or the ability to recall previous events, emotions, and places, in healthy senior people with a lower level of memory performance.
“Preclinical data have shown that polyphenols from Cerebelle can decrease the production of pro-inflammatory compounds in the brain,” said Ms. Cascella. “The published preclinical study demonstrated that these polyphenols stimulate the production of nerve growth factor in the brain with an increase in synaptic plasticity, leading to an improvement of memory. These three different pathways strengthen our understanding of the capability of Cerebelle to protect against the memory decline associated with aging.”