A multi-herb complex called CollaBZen by CK Nutraceuticals was associated with improvements in endogenous rebuilding of skin collagen, as well as improved skin hydration, elasticity, and firmness in a recent randomized, double-blind, placebo-controlled human clinical study published in the International Journal of Clinical Trials.
 
The ingredient contains a polyphenol-rich mixture of green tea, green coffee, and Indian gooseberry extracts, and the recommended dosage, as tested in the study, is 250 mg twice daily.
 
“Botanicals have been reported throughout the history to prevent skin aging but very few claims are supported by robust scientific and clinical evidences. Among the many, polyphenols are botanicals of complex structures and used in cosmetics for their skin care benefits,” the authors wrote. They noted that previous studies on the polyphenol-rich ingredient in vitro found that it was associated with enhanced collagen production in dermal fibroblast cells at a concentration typical of what would be achieved with oral supplementation.
 
The study enrolled 64 men and women with crow’s feet wrinkles, who were randomized to receive either a placebo or a daily supplement containing CollaBZen, with dermatological parameters evaluated at the fourth and eighth week.
 
The treatment group saw significant improvements in measured deep skin hydration, facial skin elasticity, and firmness at eight weeks, with the treatment group also reporting significantly higher satisfaction levels regarding their perceived skin health compared to placebo.
 
“Over the years, the botanicals extracted from amla, green tea, and coffee are implemented in skin care regimen protecting the skin from harmful effects on chronological and accelerated aging,” the authors concluded. “However, the combination of these potent polyphenol-rich plant materials in CollaBZen, until now, were not investigated for its potential to enhance collagen production in vitro and combat signs of aging in human volunteers.”