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    Breaking News

    Vitamin K2 Stability Linked with Purity Profile

    Synthetic MK7 showed the lowest purity profile characterized by 23 species accounting for 5.67% of the unknown components.

    Vitamin K2 Stability Linked with Purity Profile
    05.01.19
    A study published in the journal Molecules shows that the higher purity profile of vitamin K2 as MK7 correlates with enhanced stability in formulations. This finding could explain discrepancies found in finished products analyzed in the worldwide market in recent years.

    The study compared the purity profiles of different raw materials and the results were related to stability assay in normal (12months/25°C/60%RH) and accelerated conditions (6 months/40°C/75% RH) in order to test their performance in the presence of different common excipients. In particular, two naturally fermented MK7 and a synthetic one, all commercially available, were used. 

    All the active ingredients were independently formulated with minerals largely used on the market in combination with MK7. Finally, experimental observations were complemented by comparison of the actual/nominal content of MK7 in different formulations commercially available on the international markets, where the producers state on their labels the source of MK7 used to manufacture the finished products. 

    Data highlighted that different purity profiles corresponded to different stability profiles, where pure products generally showed the highest stability. Moreover, the study explained that patterns of instability could be associated with types of MK7 characterized by different purity profiles. 

    In particular, the multiplicity of chromatographic impurities was frequently observed and consistently associated with lower content of the all-trans isomer (isomeric purity) or with an underestimation of the assay, despite the fact that an overage of the supplement formula is a common practice to minimize the risk of degradation and, consequently, of a lower assay of the formula. Moreover, the study has highlighted that, though it is very likely that menaquinones show a very high thermal stability while they may be degraded following exposure to UV radiation and alkaline compound, the destabilizing effect of the minerals was not identical in the presence of different MK7. The synthetic MK7 showed the lowest purity profile characterized by 23 species accounting for 5.67% of the unknown components. 

    The study also reinforces the concept that MK7 materials, which equally comply to minimal assay and composition characteristics as detailed by the official USP quality standard for dietary ingredients, may be different in terms of their purity profiles due to the presence of cis isomers and other impurities. 

    Commenting on the study, Silvia Pisoni, marketing manager of the Gnosis by Lesaffre said, “VitaMK7 is one of the naturally fermented MK7 ingredient tested in the study, with positive results in line with our current campaign of information about quality and stability. We really believe this work can help all players and actors in the vitamin k2 as MK7 market to shed a light on this amazing ingredient and on its chemical behavior.” 
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