Due to the unique and novel bioactive substances in Curcumin Ultra, the product works to combat a multitude of conditions including acute and chronic pain and inflammation, according to the company. Curcumin Ultra is fast-acting and has increased stability in comparison to other curcumin products on the market, meaning Curcumin Ultra can stay in the blood for over 24 hours, the company said. Curcumin Ultra softgels have been formulated and manufactured to contain 153 mg of CurQfen, and 84 mg of Turmacin.
Curcumin is the active ingredient in the turmeric plant (Curcuma longa); a yellow spice commonly used in curry dishes. Pre-clinical and human trials have highlighted the health-promoting effects of curcumin, namely its role as an antioxidant, anti-inflammatory and pain-relieving agent.
Biochemical analysis has shown that curcumin is insoluble in water and gastrointestinal fluid due to its chemical structure. Other issues include its rapid breakdown and elimination from the body, and the fact that it is poorly absorbed by cells. It also has difficulty crossing the blood brain barrier (BBB). All of these factors limit its use as an effective natural anti-inflammatory and pain reliever.
According to AOR, Curcumin Ultra overcomes issues such as poor bioavailability, while also providing long lasting effects for 24 hours. CurQfen contains curcumin with fenugreek dietary fiber rich in galactomannans, which have a unique property of binding with both lipid- as well as water-soluble molecules. Galactomannans bind and “coat” the curcumin molecule, improving its water solubility and bioavailability. Furthermore, galactomannans coating offer a protective effect against the conjugating enzymes present in the liver, thus ensuring very high plasma levels of free-form curcumin. Approximately 75% of the curcumin in CurQfen is in its bioactive free-form, and this is the only curcumin formulation on the market whereby the ratio of conjugated to free-form curcumin has been actually measured. Despite the fact that CurQfen is water dispersible, it is not water-soluble. As such, AOR has combined it with Turmacin, which contains water-soluble turmeric polysaccharides. This blend improves CurQfen water solubility, which further improves free-form bioavailability. Preliminary human clinical trials have shown promising effects of Turmacin, namely its role as an anti-inflammatory agent in osteoarthritis.