08.07.14
The American Chemical Society published a new study examining the effects of Glutathione (GSH) by oral administration in its peer-reviewed Journal of Agricultural & Food Chemistry. Researchers with KOHJIN Life Sciences produced the report demonstrating mitochondrial biogenesis associated with the ingestion of Glutathione.
While the medical community at large knew the tripeptide was omnipresent in the human body and served to regulate all cell activity, it was undetermined whether supplementation could contribute to its presence. Until now, researchers lacked evidence of the deproteinized fraction of blood plasma in human subjects after oral intake of GSH.
To prove this correlation, KOHJIN researchers, in cooperation with a team from Kyoto Prefectural University led by Dr. Kenji Sato, examined plasma fractionated on the basis of molecular mass from human volunteers, where they discovered GSH in the protein-bound fraction of the plasma. Animal models indicated the same result, where 13C-labeled GSH showed its presence in the liver, at levels of 8% or more, in as little as two hours after one dose.
Benefits of GSH range from discharging the body of toxins and expunging free radicals from the system, to combating aging, pollution, stress, bolstering liver function, beautifying the complexion, and reenergizing exhausted muscles.
Further promoting the benefits of GSH, researchers from KOHJIN Life Sciences, Kyoto Prefectural University, and the Karolinska Institutet presented a report on in vivo/human clinical studies, which demonstrated GSH’s ability to restore muscular energy through oral intake and absorption. The studies demonstrate, for the first time, mitochondrial biogenesis associated with the ingestion of a food product. They show that oral intake of GSH (KOHJIN Glutathione, U.S. FDA GRAS Notified GRN #000293) resulted in a PGC-1α, Mitochondrial DNA and AMP activated-kinase expression in skeletal muscle, which can lead to acceleration of fatty acid utilization through activation of mitochondrial aerobic metabolism. These results suggest that GSH improves lipid metabolism and acidification in muscle during exercise, which leads to the decrease of muscle fatigue.
KOHJIN will be hosting a seminar at this year’s 248th American Chemical Society (ACS) annual meeting in San Francisco on August 12th and 13th to discuss these studies along with the newly published oral absorption data.
For more information: www.kohjinls.com/en/
While the medical community at large knew the tripeptide was omnipresent in the human body and served to regulate all cell activity, it was undetermined whether supplementation could contribute to its presence. Until now, researchers lacked evidence of the deproteinized fraction of blood plasma in human subjects after oral intake of GSH.
To prove this correlation, KOHJIN researchers, in cooperation with a team from Kyoto Prefectural University led by Dr. Kenji Sato, examined plasma fractionated on the basis of molecular mass from human volunteers, where they discovered GSH in the protein-bound fraction of the plasma. Animal models indicated the same result, where 13C-labeled GSH showed its presence in the liver, at levels of 8% or more, in as little as two hours after one dose.
Benefits of GSH range from discharging the body of toxins and expunging free radicals from the system, to combating aging, pollution, stress, bolstering liver function, beautifying the complexion, and reenergizing exhausted muscles.
Further promoting the benefits of GSH, researchers from KOHJIN Life Sciences, Kyoto Prefectural University, and the Karolinska Institutet presented a report on in vivo/human clinical studies, which demonstrated GSH’s ability to restore muscular energy through oral intake and absorption. The studies demonstrate, for the first time, mitochondrial biogenesis associated with the ingestion of a food product. They show that oral intake of GSH (KOHJIN Glutathione, U.S. FDA GRAS Notified GRN #000293) resulted in a PGC-1α, Mitochondrial DNA and AMP activated-kinase expression in skeletal muscle, which can lead to acceleration of fatty acid utilization through activation of mitochondrial aerobic metabolism. These results suggest that GSH improves lipid metabolism and acidification in muscle during exercise, which leads to the decrease of muscle fatigue.
KOHJIN will be hosting a seminar at this year’s 248th American Chemical Society (ACS) annual meeting in San Francisco on August 12th and 13th to discuss these studies along with the newly published oral absorption data.
For more information: www.kohjinls.com/en/