04.23.24
Collagen-based supplements are receiving growing interest in many markets, including joint health and mobility. But within this realm, one collagen molecule stands out as a ‘unicorn’ ingredient – native (undenatured) type II collagen. Why?
In this article, Bioiberica’s Head of R&D Human and Animal Health Daniel Martínez-Puig and expert formulator and natural pharmacist David Foreman discuss the concept of a unicorn ingredient and uncover the unique qualities of native type II collagen.
From its low, effective dosage to versatility in formulations, they also share insights on how supplement developers can harness this innovative molecule to unlock its potential in mobility solutions.
Consumers seek several qualities from their dietary supplements. The five main pillars for brands to stand out are:
1. Efficacy
2. Low dosage
3. Convenient delivery formats
4. Compatibility in combination with other on-trend ingredients, and
5. Sustainability.
To thrive in the mobility market, all five factors should be prioritized as part of the formulation process.
Robust research helps manufacturers meet demand for solutions that are grounded in evidence, offer tangible health benefits, and are trusted. In the collagen market for mobility specifically, science is abundant. But more can be done to understand the mechanisms behind different collagen molecules.
“It’s one thing leveraging science-backed ingredients in the health and wellness space, but to truly be a part of the future of the market, contributing to ongoing investigations is just as important,” said Martínez-Puig. “The collagen market, especially, has become a confusing space and to clear the mist, research is pivotal. Targeted studies tailored to distinct collagen ingredients, consumer groups, and health indications, for example, are instrumental in bringing clarity to the landscape.”
He continued: “Native (undenatured) type II collagen is supported by a growing body of evidence, which is one of the reasons it’s so appealing to brands and consumers alike. With a recommended dosage of just 40 mg/day, this ingredient has been shown to effectively support long-term joint health via a specific immune-mediated mechanism of action called Oral Tolerance, a mode of action that helps to modulate the immune response against endogenous type II collagen.”
“Earlier this month, we presented the results of a new clinical trial that set out to evaluate the efficacy and tolerability of Bioiberica’s native (undenatured) type II collagen, Collavant n2, on the joint function of healthy volunteers experiencing joint discomfort post-intensive exercise. The outcomes revealed a significant reduction in joint discomfort on day 120 and an improvement in quality of life from day 90 versus baseline.1
“Moreover, our native type II collagensupported faster recovery from discomfort after exercise compared to the placebo group at day 180 ... Not only were the initial findings promising, but the positive effects of native type II collagen were observed after just 3 months. This suggests the ingredient could therefore contribute to overall satisfaction and compliance with products featuring it.”
“Native type II collagen is an attractive candidate because it’s only needed at 40 mg per day and can be incorporated into most appealing delivery formats,” said Foreman, “enabling manufacturers to explore various different avenues — traditional or non-traditional.”
This is in contrast to hydrolyzed collagen, which is required at a higher dosage of 10 g per day to be effective, “negatively impacting texture and overall taste due to the presence of protein off-notes,” Foreman added. “It also means that hydrolyzed collagens are usually delivered via powder formats which can be particularly off-putting (and more difficult to consume long-term) for your everyday consumer.”
“It’s no longer just older adults and sports enthusiasts fueling demand for these products,” noted Martínez-Puig.“Younger demographics are increasingly aware of the fundamental role mobility plays in physical and mental wellbeing. Consequently, we’re witnessing a ‘new age’ in mobility ... creating opportunities for brands to broaden their target demographics and product portfolios.”
Native type II collagen does face formulation challenges, Foreman said. “Like most functional food ingredients, the chemical stability — and therefore biological function — of native type II collagen can be significantly influenced by factors such as pH, temperature, oxygen, light, and the presence of certain chemicals used in food processing.”
Advancements in technologies and processes are helping to address these barriers, opening up more formulation possibilities.
“We know that native type II collagen helps to maintain joint collagen,” said Foreman, “so it’s a great supplement for individuals who want to take care of their joints to maintain an active lifestyle, healthy independence, and a rich quality of life. But in my experience, these consumers are likely experiencing some joint discomfort too. So why not consider a formulation that supports joint health in the long-term, while managing discomfort at the same time?”
Growing evidence demonstrates that native type II collagen is compatible with the mechanism of action of other ingredients. For example, a formulation containing Collavant n2 native type II collagen plus a Boswellia serrata extract has been shown to provide relief to individuals in just 5 days.2
“There’s also the possibility of blending different collagens, like native type II and hydrolyzed collagen,” Foreman added. “Although this combination is yet to be fully explored, it could be a marriage made in heaven by giving the body the tools it needs to nurture cartilage growth (hydrolyzed collagen) while supporting joint health longer-term (native type II collagen).”
To address sustainability concerns Bioiberica said it prioritizes the adoption of eco-friendly practices across the supply chain — whether that’s through responsible sourcing of raw materials, adopting renewable energy sources, or minimizing waste when possible.
The versatility of native type II collagen makes it an ideal choice for manufacturers looking to develop supplements for the mobility domain. Thanks to its unique properties and low dosage, native type II collagen stands out as an ingredient in this space.
2. Jain et al. AflaB2® and osteoarthritis: a multicentric, observational, post-marketing surveillance study in Indian patients suffering from knee osteoarthritis. Int J Res Orthop. 2021;7(1):110-115.
In this article, Bioiberica’s Head of R&D Human and Animal Health Daniel Martínez-Puig and expert formulator and natural pharmacist David Foreman discuss the concept of a unicorn ingredient and uncover the unique qualities of native type II collagen.
From its low, effective dosage to versatility in formulations, they also share insights on how supplement developers can harness this innovative molecule to unlock its potential in mobility solutions.
What’s a ‘Unicorn’ Ingredient?
What are the key factors that constitute a “unicorn” ingredient? And should you look for when choosing an ingredient for mobility products?Consumers seek several qualities from their dietary supplements. The five main pillars for brands to stand out are:
1. Efficacy
2. Low dosage
3. Convenient delivery formats
4. Compatibility in combination with other on-trend ingredients, and
5. Sustainability.
To thrive in the mobility market, all five factors should be prioritized as part of the formulation process.
Steeped in Science
Scientific evidence has become a key driver of progression and success in the joint health and mobility landscape.Robust research helps manufacturers meet demand for solutions that are grounded in evidence, offer tangible health benefits, and are trusted. In the collagen market for mobility specifically, science is abundant. But more can be done to understand the mechanisms behind different collagen molecules.
“It’s one thing leveraging science-backed ingredients in the health and wellness space, but to truly be a part of the future of the market, contributing to ongoing investigations is just as important,” said Martínez-Puig. “The collagen market, especially, has become a confusing space and to clear the mist, research is pivotal. Targeted studies tailored to distinct collagen ingredients, consumer groups, and health indications, for example, are instrumental in bringing clarity to the landscape.”
He continued: “Native (undenatured) type II collagen is supported by a growing body of evidence, which is one of the reasons it’s so appealing to brands and consumers alike. With a recommended dosage of just 40 mg/day, this ingredient has been shown to effectively support long-term joint health via a specific immune-mediated mechanism of action called Oral Tolerance, a mode of action that helps to modulate the immune response against endogenous type II collagen.”
“Earlier this month, we presented the results of a new clinical trial that set out to evaluate the efficacy and tolerability of Bioiberica’s native (undenatured) type II collagen, Collavant n2, on the joint function of healthy volunteers experiencing joint discomfort post-intensive exercise. The outcomes revealed a significant reduction in joint discomfort on day 120 and an improvement in quality of life from day 90 versus baseline.1
“Moreover, our native type II collagensupported faster recovery from discomfort after exercise compared to the placebo group at day 180 ... Not only were the initial findings promising, but the positive effects of native type II collagen were observed after just 3 months. This suggests the ingredient could therefore contribute to overall satisfaction and compliance with products featuring it.”
Low Dosage
Pushing the boundaries of format innovation has also become essential for brands to meet consumer preferences and stand out in a saturated market.“Native type II collagen is an attractive candidate because it’s only needed at 40 mg per day and can be incorporated into most appealing delivery formats,” said Foreman, “enabling manufacturers to explore various different avenues — traditional or non-traditional.”
This is in contrast to hydrolyzed collagen, which is required at a higher dosage of 10 g per day to be effective, “negatively impacting texture and overall taste due to the presence of protein off-notes,” Foreman added. “It also means that hydrolyzed collagens are usually delivered via powder formats which can be particularly off-putting (and more difficult to consume long-term) for your everyday consumer.”
Adaptable for Convenient Delivery Formats
While traditional forms like capsules remain a popular option, other formats like gummies, snack bars, and ready-to-drink shakes are having their moment in the spotlight.“It’s no longer just older adults and sports enthusiasts fueling demand for these products,” noted Martínez-Puig.“Younger demographics are increasingly aware of the fundamental role mobility plays in physical and mental wellbeing. Consequently, we’re witnessing a ‘new age’ in mobility ... creating opportunities for brands to broaden their target demographics and product portfolios.”
Native type II collagen does face formulation challenges, Foreman said. “Like most functional food ingredients, the chemical stability — and therefore biological function — of native type II collagen can be significantly influenced by factors such as pH, temperature, oxygen, light, and the presence of certain chemicals used in food processing.”
Advancements in technologies and processes are helping to address these barriers, opening up more formulation possibilities.
Compatibility in Multi-Ingredient Solutions
Native type II collagen’s efficacy at a low dose allows for multi-ingredient formulations. Still, the dietary supplement industry is just scratching the surface when it comes to holistic health innovation.“We know that native type II collagen helps to maintain joint collagen,” said Foreman, “so it’s a great supplement for individuals who want to take care of their joints to maintain an active lifestyle, healthy independence, and a rich quality of life. But in my experience, these consumers are likely experiencing some joint discomfort too. So why not consider a formulation that supports joint health in the long-term, while managing discomfort at the same time?”
Growing evidence demonstrates that native type II collagen is compatible with the mechanism of action of other ingredients. For example, a formulation containing Collavant n2 native type II collagen plus a Boswellia serrata extract has been shown to provide relief to individuals in just 5 days.2
“There’s also the possibility of blending different collagens, like native type II and hydrolyzed collagen,” Foreman added. “Although this combination is yet to be fully explored, it could be a marriage made in heaven by giving the body the tools it needs to nurture cartilage growth (hydrolyzed collagen) while supporting joint health longer-term (native type II collagen).”
Sustainability
Sustainability is an important purchase driver for many consumers today. However, animal-sourced ingredients like collagen can be less sustainable compared to plant-based products.To address sustainability concerns Bioiberica said it prioritizes the adoption of eco-friendly practices across the supply chain — whether that’s through responsible sourcing of raw materials, adopting renewable energy sources, or minimizing waste when possible.
The versatility of native type II collagen makes it an ideal choice for manufacturers looking to develop supplements for the mobility domain. Thanks to its unique properties and low dosage, native type II collagen stands out as an ingredient in this space.
References
1. Möller, I. et al. OARSI, 2024.2. Jain et al. AflaB2® and osteoarthritis: a multicentric, observational, post-marketing surveillance study in Indian patients suffering from knee osteoarthritis. Int J Res Orthop. 2021;7(1):110-115.
