• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains

    Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality

    Nutrition and Flavor: Formulating for Modern Product Preferences

    What Do Consumers Know About the Gut Microbiome?

    How Will the European Green Deal Impact Dietary Supplements?
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients

    IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Fact or Myth: Antioxidants Negatively Impact Iron Absorption

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Fact or Myth: Antioxidants Negatively Impact Iron Absorption

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    Caffeine-Free Energy Supplement Linked to Alertness, Fatigue Benefits

    Monk Fruit Sweetener May Have Prebiotic Activity, Study Finds

    People with Low-Fiber Diets Benefit the Most from Fiber Supplements, Study Finds

    Gut Microbiome May Be Part of Link Between Red Meat and Heart Disease Risk
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Ecuadorian Rainforest

    Verdure Sciences

    Gencor

    Botanic Healthcare LLC

    ESHA Research
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Ecuadorian Rainforest

    Verdure Sciences

    Gencor

    Botanic Healthcare LLC

    ESHA Research
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Online Exclusives

    Phytochemicals for Inflammation

    DiscoveryBioMed awarded NIH grant to delve into phytochemical treatments for inflammation.

    Related CONTENT
    • ChromaDex
    • NattoPharma Research Network Receives €4 Million Research Grant
    • Prebiotic Shown to Improve Appetite Control in Obese Children
    • Researchers Uncover Key Mechanisms of Inflammation, Cancer and Aging
    • NattoPharma Hires Sales Manager, Americas
    Joanna Cosgrove06.10.10
    In the quest to find alternative treatments for widespread conditions, the area of phytochemicals has drawn more than just a passing glance. DiscoveryBioMed, Inc. (DBM), a life sciences and biotechnology company based in Birmingham, AL, was recently awarded a $200,000 Phase 1 Small Business Innovations Research (SBIR) catalyst grant under the recovery act by the NIH to continue research into the discovery and development of anti-inflammatory phytochemicals to address complications associated with nasal and pulmonary inflammation, dermatitis and kidney disorders with an inflammatory component.
     
    DBM focuses on finding therapeutic compounds for a variety of human diseases using physiologically relevant cell culture models, preferably derived from normal and diseased adult human cells and tissues. The company specializes in forging commercial partnerships that enhance the value of SBIR grant applications from the NIH. The company also acts as a “bridge” between academic and smaller biotech entities and large pharmaceutical entities. For the purposes of this grant, the company will work with Irvine, CA-based ChromaDex Corp., who will be providing a library of natural products and phytochemicals to screen in their human cell platform.
     
    ChromaDex specializes in the development of Phytochemical and Botanical Reference Standards and the creation of associated intellectual property. ChromaDex is also committed to sustainable “Green chemistry” and provides the dietary supplement, food, beverage, nutraceutical and cosmetic industries with the novel ingredients, analytical tools and services to meet product regulatory, quality, efficacy and safety standards. 
     
    “This program is empowered by multiple human cell platforms derived from different tissues commonly afflicted by inflammatory conditions and by access to botanically-derived small molecule phytochemicals and/or extracts from our newly cemented partnership with ChromaDex,” said Erik Schwiebert, PhD, chief executive officer of DBM.
     
    Dr. Schwiebert went on to explain that DBM’s grant application evolved out of several pilot human cell-based drug discovery programs in process when the small business-specific American Reinvestment and Recovery Act (ARRA) grant mechanisms were announced. “At the same time, DBM and ChromaDex were discussing multiple points of interaction for drug discovery for chronic human diseases of mutual interest,” he said.
     
    DBM designs targeted and phenotypic high-throughput molecular screening programs where the human cell platform accelerates drug discovery and currently has programs in chronic lung diseases, obesity and diabetes, oncology, polycystic kidney disease, osteoporosis, hepatitis and inflammation. DBM has designed its grant-funded program to discover broad spectrum anti-inflammatory phytochemicals. “Other proprietary methods build biostatistical power into the program, further accelerating, streamlining and rationalizing the program,” Dr. Schwiebert explained.

    At the same time, ChromaDex will add value to its phytochemical small molecules and extracts by having DBM find a connection or value for a particular product in fighting or curtailing a particular disease.
     
    Outlining a Plan
     
    The goals of the program funded by the Recovery Act SBIR Catalyst award will be to utilize ChromaDex phytochemical small molecules and extracts to discover and validate broad spectrum anti-inflammatory candidate substances for the over-the-counter (OTC) and nutraceuticals space.
     
    “More often than not,” commented Dr. Schwiebert, “drug discovery programs begin with a primary drug screening experiment on a biochemical target included in a solution within tiny wells of a microtiter plate where the target has been removed from its native environment within a human cell. DBM believes that this leads to high attrition rate for the hit compounds found. DBM prefers to screen against these targets as well as against specific phenotypes or functions within human cell systems relevant to the biology of that cell and of the disease of interest. Said differently, the end drug will be given to a human patient; why not screen the candidate drugs on a human cell platform relevant to the biology and the disease in the primary experiment.”
     
    Using this approach, DBM’s hit compounds are subject to much lesser attrition going forward. “These methods accelerate drug discovery and accelerate translation into a therapeutic drug, driven by a therapeutics development spinout company from DBM and/or ChromaDex and/or an out-license with a suitable and interested pharma entity,” said Dr. Schwiebert.

    The grant award was activated on April 1, 2010 and at present DBM has “initiated the optimized screening program using a human nasal epithelial cell line that has heightened inflammatory phenotype.”
     
    “We already have a panel of hit compound classes that we are evaluating as we continue phytochemical screening,” Dr. Schwiebert said. “We are validating these hits on human skin and kidney cell systems as potential broad spectrum anti-inflammatory compounds. So, the first fruits are already being realized.”
     
    Looking ahead, DBM plans to apply for Phase 2 SBIR funding in late summer of 2010, with the hope of deepening the work and beginning to develop its newly found candidate drugs for the common cold, rhinitis/sinusitis, chronic lung diseases (asthma, COPD, CF), dermatitis, and kidney diseases with an inflammatory component.
    Related Searches
    • Dietary Supplement
    • Extracts
    • Natural
    • Analytical
    Related Knowledge Center
    • Dietary Supplements
    • Testing
    • Bone & Joint Health
    Suggested For You
    ChromaDex ChromaDex
    NattoPharma Research Network Receives €4 Million Research Grant NattoPharma Research Network Receives €4 Million Research Grant
    Prebiotic Shown to Improve Appetite Control in Obese Children Prebiotic Shown to Improve Appetite Control in Obese Children
    Researchers Uncover Key Mechanisms of Inflammation, Cancer and Aging Researchers Uncover Key Mechanisms of Inflammation, Cancer and Aging
    NattoPharma Hires Sales Manager, Americas NattoPharma Hires Sales Manager, Americas
    Aker BioMarine Debuts First Krill Oil Concentrate in U.S. Market Aker BioMarine Debuts First Krill Oil Concentrate in U.S. Market
    Safe & Common Sense Solutions for Weight Management Safe & Common Sense Solutions for Weight Management
    New Natural Product application compilation New Natural Product application compilation
    ChromaDex Adds to Executive Team ChromaDex Adds to Executive Team
    Obesity-Related Clinical Study of NIAGEN Commences Obesity-Related Clinical Study of NIAGEN Commences
    ChromaDex Enters Retail Commercialization Deal With BPI Sports ChromaDex Enters Retail Commercialization Deal With BPI Sports
    Brassica Gains GRAS Status for truebroc Glucoraphanin Brassica Gains GRAS Status for truebroc Glucoraphanin
    Professor Harry H.S. Fong Receives ABC’s Botanical Research Award Professor Harry H.S. Fong Receives ABC’s Botanical Research Award
    DiscoveryBioMed Receives Grant to Study Phytochemicals DiscoveryBioMed Receives Grant to Study Phytochemicals
    ChromaDex Licenses Rights for Promising Botanical ChromaDex Licenses Rights for Promising Botanical

    Related Buyers Guide Companies

    • ChromaDex

      ...
      Madeline Benoit, International Account Manager 10.30.18

    • Breaking News | Research News | Supplier News | Vitamins

      NattoPharma Research Network Receives €4 Million Research Grant

      Second EU grant will fund substantiating MenaQ7 Vitamin K2 on microcalcification.
      03.21.17

    • Breaking News | Infant & Children's Health | Probiotics & Prebiotics | Research | Research News

      Prebiotic Shown to Improve Appetite Control in Obese Children

      Prebiotics feed the good bacteria in the child's colon and create a feeling of fullness and reduction in energy intake.
      03.07.17


    • Breaking News | Cancer Risk | Healthy Aging | Inflammation | Research News

      Researchers Uncover Key Mechanisms of Inflammation, Cancer and Aging

      Telomeres play key roles in a number of health conditions.
      02.27.17

    • People News

      NattoPharma Hires Sales Manager, Americas

      Collene Villalobos joins the company’s sales team.
      10.10.16

    Loading, Please Wait..
    Trending
    • First Day Life Shuts Down Children's Behavioral, Cognitive Health Claims Following Challenge
    • Study Examines Vitamin K2 Content In Cheese
    • Chenland Nutritionals Self-Affirms GRAS For Cumin UP60 Ingredient
    • Pycnogenol Evidenced To Have Skin Benefits In Dermatology Study
    • ADM And Benson Hill Partner To Scale High Protein Soy For U.S. Market
    Breaking News
    • Charlotte’s Web Sports Product Line to Undergo NSF Certification Process
    • ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    • Tazo Transitions to Regenerative Organic Agriculture
    • Protein Ingredient Formulated for Chronic Kidney Disease Patients
    • IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    View Breaking News >
    CURRENT ISSUE

    July/August 2022

    • A Growing Herbal Products Market Still Faces Formidable Threats, Challenges
    • Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality
    • Nutrition and Flavor: Formulating for Modern Product Preferences
    • Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains
    • How Will the European Green Deal Impact Dietary Supplements?
    • What Do Consumers Know About the Gut Microbiome?
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process
    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    Tazo Transitions to Regenerative Organic Agriculture
    Coatings World

    Latest Breaking News From Coatings World

    SONGWON Industrial Group Reports Strong Q2 Financial Results
    PPG Completes COLORFUL COMMUNITIES Project for Boys & Girls Clubs of Greater Houston
    Paul N. Gardner Now Offers Bacharach Sling Psychrometer
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    'Graft-on-a-Chip' Built to Improve Vascular Graft Success
    Abbott Invests €440 in New Irish Facility
    FDA Approves Guardant Health's NGS-Based Companion Diagnostic
    Contract Pharma

    Latest Breaking News From Contract Pharma

    AskBio Appoints Clinical Ops Executives
    SpectrumX Partners With UK Contract Manufacturer
    GL Chemtec Partners with Edgewater Capital to Accelerate Growth
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Arkay Chairman Emeritus Howard Kaneff Has Died
    Nutricosmetics Market to Hit $13.7 Billion by 2030
    Estée Lauder Pledges 100% Electric Fleet of Vehicles by 2030
    Happi

    Latest Breaking News From Happi

    J&J To Stop Global Sales of Talc-Based Products by 2023
    Net Sales Increase 2% for Naples Soap Company in Second Quarter
    Net Revenue Down 12% for Grove Collaborative in Second Quarter
    Ink World

    Latest Breaking News From Ink World

    Heidelberg Enjoys Successful Start to 2022-23 Fiscal Year
    Mimaki Announces New LATAM Website
    Paul N. Gardner Offers Bacharach Sling Psychrometer
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Esko, Constantia Flexibles announce acquisitions and more
    Hybrid Software joins The Flexo Xperience Center
    Flexo Wash LLC and Mike Potter celebrate 20 years
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Focke & Co. to Host Destination: Your Hygiene Hub on August 31
    Exports Dominate Chinese Trade of Tissues, Hygiene Products and Wipes
    Freudenberg to Present Friction Inserts for Wind Energy
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Dental 3D Printing Market is Expanding 20% Annually
    Study Results Released for Abbott's Concussion Blood Test
    Bone Growth Stimulators Market to Top $3B by 2030
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    eMagin Corporation Announces 2Q 2022 Results
    Zebra Technologies’ Emission Reduction Targets Validated by SBTi
    Identiv Delivers Impressive 41% Year-over-Year Growth in RFID Business

    Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login