09.12.23
Maypro’s postbiotic ingredient, a heat-killed version of Lactobacillus acidophilus L-92, may help to suppress local cold symptoms, such as sore throat, fatigue, cough, and chills, according to a study involving 180 participants. The findings were published in Japanese Pharmacology & Therapeutics.
In the study, 180 healthy adults who were susceptible to colds were administered either a placebo or a daily test powder containing 50 billion L-92 cells daily for 24 weeks, over the course of which symptoms were assessed by diary scores. The frequency of a full range of cold-like symptoms was significantly reduced compared to placebo.
In addition to these subjective markers of immune function, testing revealed that supplemented participants experienced activation of plasmacytoid dendritic cells (pDCs) which, in addition to innate protective function, are key in influencing the body’s adaptive response, namely by activating NK cells and T cells.
“[L-92] seems to be involved in both innate and acquired immunity,” the authors concluded. “In short, digestion of [L-92] might contribute to suppression of the onset of disease by IgA or innate immune cells, and even if the pathogens have entered the body, the duration of the symptoms is mildly suppressed by the activation of pDCs and macrophages.”
"The area of postbiotics and synbiotics is undergoing tremendous growth as we better understand their potential to influence and beneficially modulate various physiological processes.” said Denis Alimonti, director of U.S. nutrition at Maypro. “L-92’s previous studies relate to atopic dermatitis and allergic rhinitis immune response. This latest clinical study further demonstrates L-92’s beneficial impact on both the innate and adaptive immune system response. When we couple this with good formulation stability and a strong safety record, we believe L-92 is a dynamic ingredient and well positioned to grow within the postbiotics category.”
On a broad level, postbiotics, which are bioactive compounds, metabolic byproducts, and cell components produced during the fermentation of substrates by probiotics, or heat-sterilized probiotics, are attracting attention for their potential to benefit immunity, Maypro reports.
“Through our wide range of delicious and distinctly unique products including confectionery, health foods, supplements, baby formula, baby foods, nursing foods and other nursing products, freeze-dried foods, and various food ingredients, we continue to be fully committed to solving societal issues and helping customers to develop healthy minds and bodies, and we’re proud that L-92 is an important example of that commitment to human health,” said Hiroshi Kawahara, president and representative director of Asahi Group Foods, parent company of Maypro.
In the study, 180 healthy adults who were susceptible to colds were administered either a placebo or a daily test powder containing 50 billion L-92 cells daily for 24 weeks, over the course of which symptoms were assessed by diary scores. The frequency of a full range of cold-like symptoms was significantly reduced compared to placebo.
In addition to these subjective markers of immune function, testing revealed that supplemented participants experienced activation of plasmacytoid dendritic cells (pDCs) which, in addition to innate protective function, are key in influencing the body’s adaptive response, namely by activating NK cells and T cells.
“[L-92] seems to be involved in both innate and acquired immunity,” the authors concluded. “In short, digestion of [L-92] might contribute to suppression of the onset of disease by IgA or innate immune cells, and even if the pathogens have entered the body, the duration of the symptoms is mildly suppressed by the activation of pDCs and macrophages.”
"The area of postbiotics and synbiotics is undergoing tremendous growth as we better understand their potential to influence and beneficially modulate various physiological processes.” said Denis Alimonti, director of U.S. nutrition at Maypro. “L-92’s previous studies relate to atopic dermatitis and allergic rhinitis immune response. This latest clinical study further demonstrates L-92’s beneficial impact on both the innate and adaptive immune system response. When we couple this with good formulation stability and a strong safety record, we believe L-92 is a dynamic ingredient and well positioned to grow within the postbiotics category.”
On a broad level, postbiotics, which are bioactive compounds, metabolic byproducts, and cell components produced during the fermentation of substrates by probiotics, or heat-sterilized probiotics, are attracting attention for their potential to benefit immunity, Maypro reports.
“Through our wide range of delicious and distinctly unique products including confectionery, health foods, supplements, baby formula, baby foods, nursing foods and other nursing products, freeze-dried foods, and various food ingredients, we continue to be fully committed to solving societal issues and helping customers to develop healthy minds and bodies, and we’re proud that L-92 is an important example of that commitment to human health,” said Hiroshi Kawahara, president and representative director of Asahi Group Foods, parent company of Maypro.
