• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    A Clearer Path to Weight Management: The Ozempic Factor

    Under Pressure: Stress and Mental Health Have Taken Center Stage

    Sustainable Business Development: Principles and Strategies for Progress

    Beauty IO MarketWatch: L’Oréal to Define the Next Era of Beauty Tech in CES 2024 Keynote

    Introducing the Happi & Nutraceuticals World Wellness Conference & Tabletop Exhibition
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Glossary
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    GOED Releases Sustainability Report for Omega-3s Industry

    ABC’s Journal HerbalGram Celebrates 40th Anniversary

    Curcumin May Be As Effective as PPI for Indigestion

    Adding Human Milk Component to Formula Linked to Long-term Cognitive Benefits for Babies

    Women in Nutraceuticals Launches Pilot Mentorship Program
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    GOED Releases Sustainability Report for Omega-3s Industry

    ABC’s Journal HerbalGram Celebrates 40th Anniversary

    Curcumin May Be As Effective as PPI for Indigestion

    Weight Loss Products Sold as Supplements Adulterated with Toxic Yellow Oleander

    Nature’s Way Canada Launches NutraSea Omega-3 Kids Chews
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    GOED Releases Sustainability Report for Omega-3s Industry

    ABC’s Journal HerbalGram Celebrates 40th Anniversary

    Curcumin May Be As Effective as PPI for Indigestion

    Adding Human Milk Component to Formula Linked to Long-term Cognitive Benefits for Babies

    Women in Nutraceuticals Launches Pilot Mentorship Program
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Curcumin May Be As Effective as PPI for Indigestion

    Adding Human Milk Component to Formula Linked to Long-term Cognitive Benefits for Babies

    Weight Loss Products Sold as Supplements Adulterated with Toxic Yellow Oleander

    Nature’s Way Canada Launches NutraSea Omega-3 Kids Chews

    Kyowa Hakko's Immuse Postbiotic Introduced to Mexican Market
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Aiya America, Inc. (Aiya Matcha)

    Bioenergy Life Science, Inc. (BLS)

    American FlexPack

    Sabinsa Corporation

    Xsto Solutions
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Aiya America, Inc. (Aiya Matcha)

    Bioenergy Life Science, Inc. (BLS)

    American FlexPack

    Sabinsa Corporation

    Xsto Solutions
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    VITAL Ancillary Study Finds No Link Between Vitamin D and Bone Fracture Risk

    Andrea Wong, PhD, SVP of scientific and regulatory affairs for CRN, said with no control for calcium, the results are highly limited.

    VITAL Ancillary Study Finds No Link Between Vitamin D and Bone Fracture Risk
    08.02.22
    In an ancillary study from the results of the Vitamin D and Omega-3 Trial (VITAL), one of the largest human clinical trials in history on both vitamin D and omega-3 supplementation, researchers noted that there were no significant associations between vitamin D consumption and bone fracture risk among the population, which was comprised of men over the age of 50 and women over the age of 55.
     
    Participants of VITAL were not recruited on the basis of vitamin D deficiency, low bone mass, or osteoporosis, and incident fractures were reported by participants on annual questionnaires, with following medical review.
     
    Among 25,871 participants, 1,991 incident fractures were confirmed in 1,551 people over a mean follow-up period of 5.3 years. With 769 participants in the vitamin D group and 782 placebo group having experienced a fracture during the study period, there were no significant associations between vitamin D supplementation and incident fracture risk, nonvertebral fractures, or hip fractures. There were no substantial between-group differences in adverse events including fractures, including characteristics such as age, sex, race, ethnic group, body-mass index, or blood concentrations of vitamin D.
     
    “Vitamin D3 supplementation did not result in a significantly lower risk of fractures than placebo among generally healthy midlife and older adults who were not selected for vitamin D deficiency, low bone mass, or osteoporosis,” the authors concluded.
     
    In an accompanying editorial Steven R. Cummings, MD, and Clifford Rosen, MD, wrote, “VITAL and this ancillary study show that vitamin supplements do not have important health benefits in the general population of older adults, even in those with low 25-hydroxyvitamin D levels,” citing a number of other ancillary studies concluding that vitamin D did not have significant associations with cancer, cardiovascular disease, and a number of other diseases. VITAL concluded that there was a 25% reduction of cancer risk when excluding the first two years of follow-up, though accounting for all five years did not result in a significant association between vitamin D and cancer.  
     
    However, Cummings and Rosen note that in the 20% of participants who took supplemental calcium, vitamin D supplementation was not significantly associated with a reduced risk of fractures over the median follow-up period. However, the authors wrote that for those suffering from hypocalcemia, the potential benefits of vitamin D remain uncertain. “More than 10 million serum 25-hydroxyvitamin D tests are performed annually in the United States. Results from these tests often include the classification of vitamin D “insufficiency” (<30 ng per milliliter) and “deficiency” (<20 ng per milliliter), prompting vitamin D supplementation. In this ancillary study and other VITAL studies, no subgroups defined according to baseline 25-hydroxyvitamin D level, even below 20 ng per milliliter, benefited from supplements. Thus, there is no justification for measuring 25-hydroxyvitamin D in the general population or treating to a target serum level,” the authors wrote, noting that the use of the terms vitamin D “insufficiency” and “deficiency” should now be reconsidered.
     
    “The fact that vitamin D had no effect on fractures should put to rest any notion of an important benefit of vitamin D alone to prevent fractures in the larger population.”
     
    No Control for Calcium Presents a Glaring Limitation

     
    According to Andrea Wong, PhD, senior vice president of scientific and regulatory affairs for the Council of Responsible Nutrition (CRN), it is not surprising to see that a causal link couldn’t be established given that the VITAL researchers did not account for calcium intake among the participants.
     
    “Vitamin D and calcium work in tandem to support bone health—calcium helps build and maintain bones, while vitamin D helps your body effectively absorb calcium,” Wong said. “So, these secondary study results are not surprising since VITAL was designed to assess vitamin D supplementation alone and did not include or control for calcium supplementation and intake. It seems obvious that investigating one without the other would produce disappointing results.
     
    “Further, the study focused only on generally healthy midlife or older adults instead of individuals with vitamin D deficiency, low bone mass, or osteoporosis who may be more vulnerable to fractures and derive a benefit from vitamin D supplementation. The odds were stacked against this ancillary study before it even started.”
     
    Despite the limitations of the ancillary study, VITAL yielded promising results for vitamin D’s impact on cancer-related death and autoimmune diseases, which the accompanying editorial to the ancillary study ignored, Wong said. She noted that advising that the general population should not supplement with vitamin D despite recorded widespread inadequacies is concerning.
     
    “The fact remains that vitamin D is an essential nutrient that supports numerous biological functions,” Wong wrote. “Dietary studies have repeatedly shown many people still fall short of obtaining adequate levels of vitamin D and may be missing out on health benefits. The most recent Dietary Guidelines for Americans identifies vitamin D as a ‘nutrient of public health concern.’ Advising people to stop taking vitamin D supplements when natural food sources of this nutrient are scarce and sun exposure may not be feasible for those who are most vulnerable, is a disservice to public health.
     
    “People should discuss with their healthcare practitioner whether testing their vitamin D levels or supplementing with vitamin D is appropriate.”
     
     
    Related Searches
    • Bone & Joint Health
    • Vitamins
    • Dietary Supplements
    • Research
    Related Knowledge Center
    • Bone & Joint Health
    • Dietary Supplements
    • Research
    • Vitamins
    Suggested For You
    Women in Nutraceuticals Launches Pilot Mentorship Program Women in Nutraceuticals Launches Pilot Mentorship Program
    Probiotix Health Launches New Heart Health Supplement CholBiome Probiotix Health Launches New Heart Health Supplement CholBiome
    Fatty Acid Supplement Linked to Better Vision in Preterm Babies Fatty Acid Supplement Linked to Better Vision in Preterm Babies
    Ashwagandha Extract Linked to Mood and Cognitive Benefits in Several New Studies Ashwagandha Extract Linked to Mood and Cognitive Benefits in Several New Studies
    The Rise of Phytonutrients and Opportunities for Innovative Formulations The Rise of Phytonutrients and Opportunities for Innovative Formulations
    Natural Products Technical Support Specialist - Barrington, IL Natural Products Technical Support Specialist - Barrington, IL
    Ashwagandha/Okra Complex Linked to Digestive, Mood Benefits Ashwagandha/Okra Complex Linked to Digestive, Mood Benefits
    Suanfarma Opens New Facility in Utah, Achieves Fair for Life Certifications Suanfarma Opens New Facility in Utah, Achieves Fair for Life Certifications
    Clinical Trial Shows Long-Term Joint Health Benefits of PLT’s Boswellia Serrata Extract Clinical Trial Shows Long-Term Joint Health Benefits of PLT’s Boswellia Serrata Extract
    Probiotic Blend Linked to Improved Mood Scores Probiotic Blend Linked to Improved Mood Scores
    Probiotic Strain May Reduce Listeria Infections: Animal Study Probiotic Strain May Reduce Listeria Infections: Animal Study
    Sustainable Business Development: Principles and Strategies for Progress  Sustainable Business Development: Principles and Strategies for Progress
    ICYMI: Top Content from August 2023 on NutraceuticalsWorld.com ICYMI: Top Content from August 2023 on NutraceuticalsWorld.com
    Ferrous Bisglycinate Linked to Better Efficacy, Fewer Side Effects than Other Iron Salts Ferrous Bisglycinate Linked to Better Efficacy, Fewer Side Effects than Other Iron Salts
    Botanical Authentication: Food Scientists Develop New Test Method to Validate Ingredients Botanical Authentication: Food Scientists Develop New Test Method to Validate Ingredients

    Related Breaking News

    • Breaking News | Dietary Supplements | Industry & Market News
      Women in Nutraceuticals Launches Pilot Mentorship Program

      Women in Nutraceuticals Launches Pilot Mentorship Program

      The six-month program is designed to help senior-level women interested in advancing their career to C-suite and board positions in the nutraceuticals industry.
      09.20.23

    • Breaking News | Cardiovascular Health | Dietary Supplements | Medical Nutrition | Probiotics & Prebiotics | Supplier News | Vitamins
      Probiotix Health Launches New Heart Health Supplement CholBiome

      Probiotix Health Launches New Heart Health Supplement CholBiome

      The formulation contains Lactobacillus plantarum LPLDL, K2Vital Delta from Kappa Bioscience, and thiamine, a form of vitamin B1 with an EFSA heart health claim.
      09.14.23

    • Breaking News | Dietary Supplements | Eye Health | Fatty Acids | Infant & Children's Health | Medical Nutrition | Omega-3s | Research News
      Fatty Acid Supplement Linked to Better Vision in Preterm Babies

      Fatty Acid Supplement Linked to Better Vision in Preterm Babies

      A mixture of AA and DHA was linked to reduced risk of retinopathy in 178 extremely preterm babies.
      09.14.23


    • Breaking News | Cognitive Function | Dietary Supplements | Herbs & Botanicals | Mood Health & Sleep | Research | Research News | Supplier News
      Ashwagandha Extract Linked to Mood and Cognitive Benefits in Several New Studies

      Ashwagandha Extract Linked to Mood and Cognitive Benefits in Several New Studies

      Treatment with Specnova’s NooGandha was linked to positive findings in one mood study, two cognition studies, and a safety study.
      09.14.23

    • Antioxidants | Contract Manufacturing | Delivery & Dosage Technologies | Dietary Supplements | Digestive Health | Herbs & Botanicals | Probiotics & Prebiotics
      The Rise of Phytonutrients and Opportunities for Innovative Formulations

      The Rise of Phytonutrients and Opportunities for Innovative Formulations

      Move over macronutrients and micronutrients—the time for phytonutrients has come.
      By Melanie Bush, VP of Science and Research, Artemis International, Inc. 09.14.23

    Loading, Please Wait..
    Trending
    • Soviets Took Probiotics To The Next Level
    • Todd Spear Joins Protein Research As VP Of Sales And Marketing
    • New Technology Converts Sugar In Juice To Fiber
    • Shiitake Mushroom Extract Appears Helpful In HPV Infections
    • HMB And Vitamin D Supplementation Linked To Reduction In Fat Stores
    Breaking News
    • GOED Releases Sustainability Report for Omega-3s Industry
    • ABC’s Journal HerbalGram Celebrates 40th Anniversary
    • Curcumin May Be As Effective as PPI for Indigestion
    • Adding Human Milk Component to Formula Linked to Long-term Cognitive Benefits for Babies
    • Women in Nutraceuticals Launches Pilot Mentorship Program
    View Breaking News >
    CURRENT ISSUE

    September 2023

    • A Clearer Path to Weight Management: The Ozempic Factor
    • Under Pressure: Stress and Mental Health Have Taken Center Stage
    • Sustainable Business Development: Principles and Strategies for Progress
    • BIOHM Health Targets ‘Digestive Plaque’ with Probiotic, Fungus, and Enzyme Formula
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    GOED Releases Sustainability Report for Omega-3s Industry
    ABC’s Journal HerbalGram Celebrates 40th Anniversary
    Curcumin May Be As Effective as PPI for Indigestion
    Coatings World

    Latest Breaking News From Coatings World

    ACS Reports Chameleon Inspired Building Coating
    Substrate Wetting Agent Available from BRB International
    Nouryon Manufacturing Network Transitions to 100% Electricity From Renewable Sources in Brazil
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    MPO's Most-Read Stories This Week—Sept. 23
    Beckman Coulter Helping Labs Comply With Annex 1 Regulation
    FDA Clears MeMed BV Direct From Whole Blood
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Eftilagimod Cleared for Clinical Trial Use in the UK
    Veranova Names William Sanders Global VP of Chemical Development Ops
    Chime, Panolos Partner to Advance Multi-specific Therapeutic Proteins
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Hailey Bieber's Rhode Expands Into Makeup
    Avon Enters Retail Partnership with Superdrug
    IT Award Winners Announced at MakeUp in NY
    Happi

    Latest Breaking News From Happi

    Dental Care Trends and SBLA Beauty's Advertising Claims Under Scrutiny
    OffCourt Debuts in Walmart Stores Nationwide
    Gen Z Is Sweet On Smelling Good
    Ink World

    Latest Breaking News From Ink World

    Cooper Watson Acquires Tower Products
    The Durst Group Awarded Eight 2023 PRINTING United Alliance Pinnacle Awards
    Weekly Recap: Wikoff Color, HP, INX VC Top This Week’s Stories
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    PRX Market debuts, Tower Products acquired and more
    Flexo Wash to exhibit at FTA Fall Technical Conference
    Recyclable, deinkable stand-up pouch wins Gold in Germany
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Weekly Recap: Soft N' Dry Seeks to Expand Private Label Roll Out, Albis Completes Work on Line
    Lenzing Earns EU Ecolabel at Indonesian Plant
    Albis Completes Work On Extra Wide Carding, Blending Line
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    ODT's Most-Read Stories This Week—Sept. 23
    Anika Releases RevoMotion Reverse Shoulder Arthroplasty System
    Exactech's Activit-E Polyethylene OK'ed for Vantage Total Ankle
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    HID to Showcase Future-Proof Solutions at GITEX 2023
    Weekly Recap: Mergers and Acquisitions, IEC’s IME Standards Top This Week’s Stories
    EU-Funded Collaboration Hub Aims to Mainstream Printed Electronics

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login