• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Nutraceuticals for Men: Muscle Health and Performance Nutrition

    Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions

    Getting an Edge in Esports: Meeting the Health Needs of Competitive Gamers

    Beyond CBD: Cannabis Compounds Warrant Recognition and More Research

    Leveling Out the Energy Segment for Mainstream, and Rethinking Caffeine
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Thorne Relaunches Gut Health Test with Microbiome Wipe

    Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports

    GC Rieber Foundations Expand Philanthropic Efforts

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Stratum Nutrition’s Patent Portfolio Grows to Europe and Canada
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    GC Rieber Foundations Expand Philanthropic Efforts

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Botanical Ingredient MorActive Evidenced to Relieve Back Discomfort

    Cargill’s Stevia Sustainability Program Benchmarked by FSA

    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Thorne Relaunches Gut Health Test with Microbiome Wipe

    Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports

    GC Rieber Foundations Expand Philanthropic Efforts

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Stratum Nutrition’s Patent Portfolio Grows to Europe and Canada
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Thorne Relaunches Gut Health Test with Microbiome Wipe

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Beyond Raw Launches Concept X Pre-Workout Line

    Botanical Ingredient MorActive Evidenced to Relieve Back Discomfort

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Ecuadorian Rainforest

    Botanic Healthcare LLC

    ESHA Research

    Atlantia Clinical Trials

    Nutrition21, LLC
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Ecuadorian Rainforest

    Botanic Healthcare LLC

    ESHA Research

    Atlantia Clinical Trials

    Nutrition21, LLC
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    CBD Pharmacokinetics Study Compares Absorption Rate of Various Product Formats

    Published human study conducted by Colorado State University funded by Caliper Foods.

    CBD Pharmacokinetics Study Compares Absorption Rate of Various Product Formats
    Related CONTENT
    • Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports
    • Choline Alone May Improve Maternal DHA Status During Pregnancy
    • GNC Adds Products from The Honest Company, Hers, and Womaness
    • Hofseth BioCare’s CalGo Ingredient Shown to be More Absorbable than Calcium Carbonate
    • Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk in Older Adults
    Sean Moloughney, Editor02.09.21
    In collaboration with Colorado State University (CSU), Caliper Foods, a manufacturer and supplier of soluble hemp-derived cannabinoids, has completed a human clinical study on commercially available CBD-infused food and supplement product pharmacokinetics.
     
    This study was approved by an Institutional Review Board (IRB) in compliance with the requirements of 45 CFR 46 for human clinical research.
     
    Pharmacokinetics (PK) is the science of how bioactives diffuse through the body, and it reveals the difference between what we consume and what we absorb (vs. what we excrete), as well the rate and efficiency of absorption. PK studies are critical to understanding the efficacy of any bioactive compound, including CBD, since a bioactive’s effect is a function of its presence. In other words, you can’t feel what you don’t absorb. PK studies provide the scientific foundation for claims such as “fast acting,” “long lasting,” and “superior bioavailability.”
     
    To date, when CBD product manufacturers have claimed fast action or superior absorption, they have generally based those claims on mouse studies or analogies to non-cannabinoid bioactives (often curcumin). Caliper said its study represents the first human clinical substantiation of such claims, as well as the first to do so using commercially available products and an IRB-approved study design. Moreover, with the CBD industry generally mired in fraud and mistrust, this study is unique in its academic integrity, the company said. Although Caliper provided funding for the study, Colorado State University exercised complete and independent authority over the collection, analysis, and publication of these results.
     
    Conducted by CSU researchers and published in a special issue of the medical journal Pharmaceuticals titled “Cannabidiol: Advances in Therapeutic Applications and Future Perspectives,” the study compared the pharmacokinetic profiles of three proprietary soluble CBD formats—Caliper Powder, Caliper Quillaia-based Liquid Concentrate, and Caliper Gum Arabic-based Liquid Concentrate—against two control formats: oil-based CBD tincture and unemulsified CBD isolate.
     
    The blinded, randomized, crossover study design involved 15 healthy men and women, ages 21-62, each consuming 30 mg of CBD in each product format. Participants provided venous blood samples prior to ingestion, and then at regular intervals over the ensuing four hours. Blood analysis revealed that all of Caliper’s product formats were absorbed significantly faster than either control, according to the company:
     
    Caliper Powder, which is used in Caliper’s flagship consumer offerings, Caliper CBD and Caliper Swiftsticks, delivered CBD into the bloodstream 142 times faster than isolate, and 22 times faster than tincture, in the 30 minutes following ingestion, based on a comparison of observed circulating blood levels of CBD.
     
    Caliper Gum Arabic-based Liquid Concentrate (SKU: T-L-A-5), which is used in a variety of beverage, food, and supplement products, delivered CBD into the bloodstream 424 times faster than isolate, and 64 times faster than tincture, in the 30 minutes following ingestion, based on a comparison of observed circulating blood levels of CBD.
     
    Caliper Quillaia-based Liquid Concentrate (SKU: T-L-Q-20), which is used in a range of beverage, food, and supplement products in the natural foods channel, delivered CBD into the bloodstream 218 times faster than isolate, and 33 times faster than tincture, in the 30 minutes following ingestion, based on a comparison of observed circulating blood levels of CBD.
     
    “Caliper’s mission is to make consistent, convenient, and useful CBD products that feature rapid uptake and superior bioavailability—and we back it all up with rigorous clinical research. This study validates that mission,” said Nicole Maione, general manager of Caliper Consumer. “The CBD industry has unfortunately invested far more money into the promotion of unfounded marketing claims than into the research required to substantiate those claims. Caliper cares about the process as much as the data, and we want to move this industry forward by developing clinically-substantiated CBD-infused products that meet their label claims.”
     
    "It’s incumbent upon our company, our industry, and, above all, our regulatory agencies to ensure that consumer products meet the promises made on their labels. That’s why we invested heavily in a well-designed clinical study with a credible academic partner and supported its publication in an open access, peer-reviewed journal,” said Jolene Jacobs, general manager of Caliper Ingredients. “We didn’t conduct this study on mice in a lab. We used real people and real products, and the results provide real-world support for our product claims. The fact that different product formats exhibited different absorption profiles demonstrates why brands need to base their claims on empirical data rather than empty buzzwords like ‘nano’ when talking about fast action or improved absorption.”
     
    Caliper has been lobbying the FDA and Congress to regulate CBD and other hemp-derived cannabinoids. For example, Caliper has been urging FDA to hold cannabinoid manufacturers to the same baseline standards for labeling accuracy, good manufacturing practices, and claims substantiation that non-CBD food & supplement manufacturers have operated under for decades.
     
    “In their well-meaning search for better data and real world evidence, the FDA has unfortunately opted for delaying the regulatory process time and again in the alleged pursuit of enacting perfect regulation in the future over the necessity of enacting basic regulation today. The regulatory delay has, and will continue to, endanger consumers,” said Justin Singer, CEO of Caliper Foods. “We agree that real world evidence is important, which is why we’ve long urged the FDA to impose the same labeling and manufacturing requirements on hemp product manufacturers as they do on other foods and supplements. You can’t trust consumer reports of CBD usage unless you can trust the veracity of the labels on the products.”
     
    Dr. Christopher Bell from Colorado State University noted than some estimates indicate more than 20 million Americans use CBD daily. "But there is so little we understand about CBD and how everything from product format to individual physiology can affect circulating blood concentrations over time. The industry simply lacks basic scientific research and substantiation. We partnered with Caliper because they share our drive to better understand CBD and its effects on the human body, which was why testing with humans—and publishing the results in a peer-reviewed journal—was essential."
    Related Searches
    • Delivery & Dosage Technologies
    • Herbs & Botanicals
    • Research
    Related Knowledge Center
    • Research
    • Delivery & Dosage Technologies
    • Herbs & Botanicals
    Suggested For You
    Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports
    Choline Alone May Improve Maternal DHA Status During Pregnancy Choline Alone May Improve Maternal DHA Status During Pregnancy
    GNC Adds Products from The Honest Company, Hers, and Womaness GNC Adds Products from The Honest Company, Hers, and Womaness
    Hofseth BioCare’s CalGo Ingredient Shown to be More Absorbable than Calcium Carbonate Hofseth BioCare’s CalGo Ingredient Shown to be More Absorbable than Calcium Carbonate
    Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk in Older Adults Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk in Older Adults
    Vitamin Angels’ Mother’s Day Donation Campaign Raises Awareness for Maternal and Child Nutrition Vitamin Angels’ Mother’s Day Donation Campaign Raises Awareness for Maternal and Child Nutrition
    Nexira to Discuss Four New Scientific Studies at Vitafoods Europe Nexira to Discuss Four New Scientific Studies at Vitafoods Europe
    HP Ingredients and H&AD to Showcase Ingredients at Vitafoods Europe HP Ingredients and H&AD to Showcase Ingredients at Vitafoods Europe
    IFF to Discuss Customizable, Sustainable Solutions for Supplements IFF to Discuss Customizable, Sustainable Solutions for Supplements
    Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions
    Nutraceuticals for Men: Muscle Health and Performance Nutrition Nutraceuticals for Men: Muscle Health and Performance Nutrition
    Bioenergy Life Science, Inc. (BLS) Bioenergy Life Science, Inc. (BLS)
    Bonafide Acquires Patented, Enhanced SAM-e Formulation Bonafide Acquires Patented, Enhanced SAM-e Formulation
    ABC Elects Three New Members to Board of Trustees ABC Elects Three New Members to Board of Trustees
    Ovaterra Launches New Prenatal Vitamins Ovaterra Launches New Prenatal Vitamins

    Related Content

    • Breaking News | Consumer Trends | Industry & Market News | Quality & Safety | Testing
      Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports

      Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports

      The new transparency program can display testing accuracy to consumers and B2B customers.
      05.24.22

    • Breaking News | Dietary Supplements | Infant & Children's Health | Medical Nutrition | Research News | Vitamins | Women's Health
      Choline Alone May Improve Maternal DHA Status During Pregnancy

      Choline Alone May Improve Maternal DHA Status During Pregnancy

      Independently of additional DHA intake, choline supplementation resulted in higher DHA status in maternal and umbilical cord blood.
      05.19.22

    • Breaking News | Dietary Supplements | Products | Women's Health
      GNC Adds Products from The Honest Company, Hers, and Womaness

      GNC Adds Products from The Honest Company, Hers, and Womaness

      Highlighting National Women’s Health Month, the company is adding 13 products to its shelves formulated for women across life’s stages.
      05.16.22


    • Hofseth BioCare’s CalGo Ingredient Shown to be More Absorbable than Calcium Carbonate

      Hofseth BioCare’s CalGo Ingredient Shown to be More Absorbable than Calcium Carbonate

      Hydrolysis technology converts fresh sashimi-grade salmon byproducts into nutritional ingredients.
      05.12.22

    • Cancer Risk | Omega-3s | Research | Vitamins
      Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk in Older Adults

      Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk in Older Adults

      A three-year, multicenter trial known as DO-HEALTH tracked 2,157 older adults who took vitamin D and/or omega-3s both with and without exercise.
      By Mike Montemarano, Associate Editor 05.06.22

      Trending
      • Oregon Files Lawsuit Against GNC | Nutraceuticals World
      • Pycnogenol Evidenced To Have Skin Benefits In Dermatology Study | Nutraceuticals World
      • Vitamin K2 Status May Impact Blood Pressure And Pulse Wave Velocity | Nutraceuticals World
      • GC Rieber Foundations Expand Philanthropic Efforts
      • GC Rieber Foundations Expand Philanthropic Efforts | Nutraceuticals World
      Breaking News
      • Thorne Relaunches Gut Health Test with Microbiome Wipe
      • Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports
      • GC Rieber Foundations Expand Philanthropic Efforts
      • Danone Celebrates 10th anniversary of Grant Program for Probiotics Research
      • Stratum Nutrition’s Patent Portfolio Grows to Europe and Canada
      View Breaking News >
      CURRENT ISSUE

      May 2022

      • Aging in Place: Lifestyle Supplements Science-Based Solutions
      • Getting an Edge in Esports: Meeting Health & Nutrition Needs
      • Nutraceuticals for Men: Muscle Health and Performance Nutrition

      Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
      You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

      • About Us
      • Privacy Policy
      • Terms And Conditions
      • Contact Us

      follow us

      Subscribe
      Nutraceuticals World

      Latest Breaking News From Nutraceuticals World

      Thorne Relaunches Gut Health Test with Microbiome Wipe
      Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports
      GC Rieber Foundations Expand Philanthropic Efforts
      Coatings World

      Latest Breaking News From Coatings World

      What are You Reading this Week?
      Nippon Paint Automotive Americas Appoints Robert Angart CEO and President
      Sustainability, Economy are Focus of BCF’s Annual Conference
      Medical Product Outsourcing

      Latest Breaking News From Medical Product Outsourcing

      MPO's Most-Read Stories This Week—May 28
      New Breast Implant Surgery Guidelines to Enhance Patient Safety
      Rhythm Management Group Debuts RhythmSynergy Tech Platform
      Contract Pharma

      Latest Breaking News From Contract Pharma

      iECURE Enters Agreement with Center for Breakthrough Medicines
      CPDC Enters Clinical Manufacturing Deal with CellBion
      Olon to Build New R&D Center in Italy
      Beauty Packaging

      Latest Breaking News From Beauty Packaging

      K-Beauty Brand Siita Shares Plastic Decomposition Technology with the Beauty Industry
      Shellworks Raises $6.2 Million in Seed Funding
      Ulta Beauty Reports Record First Quarter 2022 Results
      Happi

      Latest Breaking News From Happi

      Global Skincare Treatment Devices Market Expected to Grow at Over 11.5% CAGR Rate Through 2028
      Technology Cuts Plastic Decomposition from 500 Years to Three Months
      Honeywell Addresses Critical Issues Such as Sustainability, Workforce Training and Digitalization
      Ink World

      Latest Breaking News From Ink World

      Weekly Recap: Flint Group, New Inks from Siegwerk and Zeller+Gmelin Lead This Week’s News
      Orion to Finish Gas Black Expansion in Germany by Early 2023
      Richard Childress Racing Shows Off New Wraps for 2022 NASCAR Season
      Label & Narrow Web

      Latest Breaking News From Label & Narrow Web

      UPM Raflatac accelerates label growth with acquisition
      Labelexpo Asia 2022 postponed
      Teklynx software helps Top Clean Injection validate labels
      Nonwovens Industry

      Latest Breaking News From Nonwovens Industry

      Rael Raises $35M in Series B Funding
      Schobertechnologies Offers Rotary Web-fed Converting Solutions
      Thorne Relaunches Gut Health Test with Microbiome Wipe
      Orthopedic Design & Technology

      Latest Breaking News From Orthopedic Design & Technology

      ODT's Most-Read Stories This Week—May 28
      Toetal Solutions Raises $1.02 Million in New Financing
      ManaMed's ManaSport Wearable Ultrasound Earns FDA Nod
      Printed Electronics Now

      Latest Breaking News From Printed Electronics Now

      Weekly Recap: OPV’s Future, Graphene Flagship and Japan Display Top This Week’s Stories
      SEMI Foundation Receives $1.5 Million Grant to Bolster Michigan’s Semiconductor Talent Pipeline
      onsemi Recognized by Fortune 500 for Its Transformation Journey

      Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

      AD BLOCKER DETECTED

      Our website is made possible by displaying online advertisements to our visitors.
      Please consider supporting us by disabling your ad blocker.


      FREE SUBSCRIPTION Already a subscriber? Login