The first study, published in Clinical, Cosmetic, and Investigational Dermatology, was conducted as an open-label, single-arm, monocentric efficacy investigation in 38 volunteers who applied a cream containing 0.4% pterostilbene to one arm for eight weeks, after which a dermatological assessment, an instrumental analysis, and an image analysis was made. The results suggested that pterostilbene effectively improves skin brightness, elasticity, and reduces the appearance of fine lines and wrinkles compared to baseline in the subjects studied.
The researchers observed a positive change at all time points in skin hydration and elasticity in both male and female subjects with regular usage of pTeroWhite cream. They found significant improvement in under-eye fine lines at all-time points and in wrinkles, frown lines, and crow’s feet area at the end of the study. The pterostilbene preparation was able to improve the skin luminosity with continuous application.
In the self-reported assessment, all subjects involved in the study agreed that the test product made their skin appear moisturized, brighter, younger, firmer, and even toned. Further, researchers observed no product-related skin irritation, intolerance, or adverse events during the study. The report concluded that the application of pterostilbene cream twice daily for eight weeks was safe and improved skin texture and tone.
A second clinical study, published in the journal Cosmetics, demonstrated that a cream formulation containing 0.4% pTeroWhite was a natural SPF ingredient. 12 healthy volunteers used the cream, according to ISO 24444:2010 regualtions, and showed an in vivo SPF value of 6.2 ±1.30. The cream was found to be safe and nonirritant in a repeated patch test conducted in 25 individuals before the SPF study. The cream showed an SPF of 8.84 ±0.01 in vitro, while pTeroWhite as a significant ingredient had an SPF value of of 21.73 ±0.06. The study also demonstrated potent antioxidant effects of pTeroWhite in various in vitro and cellular test systems. The study concluded that pTeroWhite could be a safe ingredient in topical sun-protective formulations.
“We’ve long thought that natural pterostilbene had tremendous potential in cosmeceutical applications, which is why we began conducting this research,” Sabinsa founder and chairman Dr. Muhammed Majeed said. “Investigations are continuing to further expand our knowledge to support new product applications.”