In general, kidney damage rarely happens in the first 10 years of diabetes. Kidney failure usually happens 15 to 25 years after the first symptoms of diabetes. Since diabetic nephropathy take many years to develop, 45 patients with type 2 diabetes for an average of 18.5 years were selected for this study. Their microalbuminuria-positive result was ensured to be due to diabetic nephropathy alone (microalbuminuria is an early sign for kidney disease). They were randomly divided into 2 groups:
(i) Placebo group
(ii) Intervention group receiving EVNol SupraBio
The blood serum of the patients was measured at baseline and after a short 8-weeks supplementation of either 400 mg/day EVNol SupraBio or placebo.
EVNol SupraBio bioenhanced full spectrum palm tocotrienol complex, significantly reduced serum creatinine level hence potentially averting the progression of renal impairment among the diabetic nephropathy patients.
No significant changes were observed in the level of HbA1c, serum AGE, sRAGE, Nε-CML and Cystatin C in the diabetic nephropathy patients in this study. This was the opposite to a previous study (2) on newly-induced diabetic rat model that showed supplementation of EVNol SupraBio significantly reduce the aforementioned biomarkers. As per the researchers, the lack of significant effects observed in this study could be due to the long duration of diabetes among the patients (average 18.5 years), causing a long-term and difficult-to-reverse accumulation of these biomarkers in the body. This might have hindered the reduction and led the researchers to recommend a longer supplementation time for the tocotrienol to take effect.
Nevertheless, supplementation of EVNol SupraBio— bioenhanced full spectrum palm tocotrienol complex —significantly reduced serum creatinine compared to placebo. Therefore, the researchers concluded that EVNol SupraBio may be useful in addition to the current treatment for diabetic nephropathy.
“Tocotrienol has been proven to have 40 – 60 times more potent antioxidant activity compared to tocopherol and has superior anti-inflammatory, neuroprotective and cardioprotective properties. However, the renoprotective effect of tocotrienol in type 2 diabetes patient is currently limited and we are glad the researchers choose EVNol SupraBio to investigate the effect of tocotrienol in delaying diabetic nephropathy,” said Diyanah Roslan, nutritionist at ExcelVite.
“The number of people affected by diabetes continue to increase by the year, and it is vital to search for the right remedy to help delay diabetic complications, such as diabetic nephropathy. We are glad this study demonstrates the efficacy of EVNol SupraBio in reducing creatinine level specifically, which potentially could slow down the progression of diabetic nephropathy,”added Bryan See, business development manager of ExcelVite.