• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Nutraceuticals for Men: Muscle Health and Performance Nutrition

    Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions

    Getting an Edge in Esports: Meeting the Health Needs of Competitive Gamers

    Beyond CBD: Cannabis Compounds Warrant Recognition and More Research

    Leveling Out the Energy Segment for Mainstream, and Rethinking Caffeine
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Thorne Relaunches Gut Health Test with Microbiome Wipe

    Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports

    GC Rieber Foundations Expand Philanthropic Efforts

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Stratum Nutrition’s Patent Portfolio Grows to Europe and Canada
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    GC Rieber Foundations Expand Philanthropic Efforts

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Botanical Ingredient MorActive Evidenced to Relieve Back Discomfort

    Cargill’s Stevia Sustainability Program Benchmarked by FSA

    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Thorne Relaunches Gut Health Test with Microbiome Wipe

    Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports

    GC Rieber Foundations Expand Philanthropic Efforts

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Stratum Nutrition’s Patent Portfolio Grows to Europe and Canada
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Thorne Relaunches Gut Health Test with Microbiome Wipe

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Beyond Raw Launches Concept X Pre-Workout Line

    Botanical Ingredient MorActive Evidenced to Relieve Back Discomfort

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Xsto Solutions

    Botanic Healthcare LLC

    Atlantia Clinical Trials

    Verdure Sciences

    Nutrition21, LLC
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Xsto Solutions

    Botanic Healthcare LLC

    Atlantia Clinical Trials

    Verdure Sciences

    Nutrition21, LLC
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Probiotic May Reverse Depression Symptoms in Mice

    Lactobacillus shown to affect mood, anxiety in mice; researchers optimistic discovery could apply to humans.

    Related CONTENT
    • Consumer Conviction: Results of consumer satisfaction study on mental wellness and sleep.
    • FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Products
    • Beyond CBD: Cannabis Compounds Warrant Recognition and More Research
    • Digestive, Gut Health Solutions Offer Downstream Benefits
    • Bridging Gaps in Women’s Health with Renewed Attention
    03.08.17
    Researchers at the University of Virginia School of Medicine have reversed depression symptoms in mice by feeding them Lactobacillus, a probiotic bacteria found in live-cultures yogurt. Further, they have discovered a specific mechanism for how the bacteria affect mood, providing a direct link between the health of the gut microbiome and mental health.
     
    Based on their findings, published online by the scientific journal Scientific Reports, the researchers are optimistic that their discovery will hold true in people and are planning to confirm their findings in patients with depression.
     
    “The big hope for this kind of research is that we won’t need to bother with complex drugs and side effects when we can just play with the microbiome,” explained lead researcher Alban Gaultier, PhD. “It would be magical just to change your diet, to change the bacteria you take, and fix your health—and your mood.”
     
    Treating Depression
    Depression is one of the most common mental health conditions in the U.S., with up to 7% of people experiencing a major depressive episode, Dr. Gaultier noted. “It’s a huge problem and the treatments are not very good, because they come with huge side effects,” he said.
     
    The role of the gut microbiome—the bacteria that live inside us—has been of tremendous interest to researchers studying depression and other health conditions, both mental and physical. Dr. Gaultier, of the UVA Department of Neuroscience and its Center for Brain Immunology and Glia, set out to see if he could find a concrete link between depression and gut health. “When you’re stressed, you increase your chance of being depressed, and that’s been known for a long, long time,” he said. “So the question that we wanted to ask is, does the microbiome participate in depression?”
     
    The answer appears to be yes. Looking at the composition of the gut microbiome before and after mice were subjected to stress, Dr. Gaultier’s team found that the major change was the loss of Lactobacillus. With the loss of Lactobacillus came the onset of depression symptoms. Feeding the mice Lactobacillus with their food returned them to almost normal. “A single strain of Lactobacillus,” Dr. Gaultier observed, “is able to influence mood.”
     
    He and his team then went on to determine the mechanism by which Lactobacillus influences depression. They found that the amount of Lactobacillus in the gut affects the level of a metabolite in the blood called kynurenine, which has been shown to drive depression. When Lactobacillus was diminished in the gut, the levels of kynurenine went up – and depression symptoms set in.
     
    “This is the most consistent change we’ve seen across different experiments and different settings we call microbiome profiles,” explained researcher Ioana Marin, a graduate student who is finishing up her PhD work. “This is a consistent change. We see Lactobacillus levels correlate directly with the behavior of these mice.”
     
    Testing in Humans
    Dr. Gaultier was careful to call the symptoms seen in mice as “depressive-like behavior” or “despair behavior,” as mice have no way to communicate that they are feeling depressed. But those symptoms are widely accepted as the best available model for looking at depression in creatures other than humans.
     
    Based on the new findings, Dr. Gaultier plans to begin studying the effect in people as soon as possible. He intends to examine the effects of Lactobacillus on depression in patients with multiple sclerosis, a group in which depression is common. Promisingly, the same biological substances and mechanisms Lactobacillus uses to affect mood in mice are also seen in humans, suggesting the effect may be the same.
     
    In addition to looking at the effects in people, the researchers are continuing to explore the important role of kynurenine. “There has been some work in humans and quite a bit in animal models talking about how this metabolite, kynurenine, can influence behavior,” Marin said. “It’s something produced with inflammation that we know is connected with depression. But the question still remains: How? How does this molecule affect the brain? What are the processes? This is the road we want to take.”
     
    While there is no harm in people with depression eating yogurt—assuming they have no problem eating dairy—people receiving treatment for depression should not stop taking their medications without consulting their physicians. More studies, the researchers noted, are needed.
     
    For more on this discovery, including answers to questions such as whether the strain of Lactobacillus affects the effect on depression, visit the UVA School of Medicine's research blog, the Making of Medicine, at https://makingofmedicine.virginia.edu
     
    Findings Published
    The findings have been published online by the scientific journal Scientific Reports. This interdisciplinary study is the product of a collaboration among several laboratories and centers at UVA. The article is the work of Marin, Jennifer E. Goertz, Tiantian Ren, Stephen S. Rich, Suna Onengut-Gumuscu, Emily Farber, Martin Wu, Christopher C. Overall, Jonathan Kipnis and Gaultier.
     
    The research was made possible by an initial seed grant from UVA’s Office of the Vice President for Research. The work then received financial support from the National Multiple Sclerosis Society and the National Institutes of Health’s National Institute of Mental Health, grant R21 MH108156.
     
    The finding continues a streak of major discoveries from UVA’s Department of Neuroscience that have generated headlines around the world.
    Related Searches
    • Lactobacillus
    • Stress
    • Probiotic
    • Dairy
    Related Knowledge Center
    • Research
    • Mood Health & Sleep
    • Probiotics & Prebiotics
    Suggested For You
    Consumer Conviction: Results of consumer satisfaction study on mental wellness and sleep. Consumer Conviction: Results of consumer satisfaction study on mental wellness and sleep.
    FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Products  FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Products
    Bridging Gaps in Women’s Health with Renewed Attention Bridging Gaps in Women’s Health with Renewed Attention
    Digestive, Gut Health Solutions Offer Downstream Benefits Digestive, Gut Health Solutions Offer Downstream Benefits
    Beyond CBD: Cannabis Compounds Warrant Recognition and More Research Beyond CBD: Cannabis Compounds Warrant Recognition and More Research
    The Nuts and Bolts of FDA’s 2023 Budget Request The Nuts and Bolts of FDA’s 2023 Budget Request
    Nutralliance/Ildong Achieve GRAS for Probiotic Strains Nutralliance/Ildong Achieve GRAS for Probiotic Strains
    PanTheryx Launches Probiotic-Colostrum Combo Ingredients PanTheryx Launches Probiotic-Colostrum Combo Ingredients
    Zeller Receives ABC Varro E. Tyler Award for Excellence in Phytomedicinal Research Zeller Receives ABC Varro E. Tyler Award for Excellence in Phytomedicinal Research
    Botanical Extract Linked to Positive Sleep, Anxiety-Related Outcomes Botanical Extract Linked to Positive Sleep, Anxiety-Related Outcomes
    Probiotic Supplement May Improve Cholesterol Profiles Probiotic Supplement May Improve Cholesterol Profiles
    House Wellness Foods’ Postbiotic HK L-137 Receives Approval from FSANZ House Wellness Foods’ Postbiotic HK L-137 Receives Approval from FSANZ
    DSM Gains New Dietary Ingredient Status for Two Probiotic Strains in U.S. DSM Gains New Dietary Ingredient Status for Two Probiotic Strains in U.S.
    Lonza’s TWK10 Sports Probiotic Lands in Europe Lonza’s TWK10 Sports Probiotic Lands in Europe
    Flavonoids Reduce All-Cause Mortality Risk in Parkinson’s Disease Patients Flavonoids Reduce All-Cause Mortality Risk in Parkinson’s Disease Patients

    Related Content

    • Consumer Conviction: Results of consumer satisfaction study on mental wellness and sleep.

      Consumer Conviction: Results of consumer satisfaction study on mental wellness and sleep.

      Register now for our FREE Webinar on Wednesday, June 8, 2022; 10AM EST!
      05.18.22

    • Breaking News | Dietary Supplements | Industry & Market News | Quality & Safety | Sports Nutrition
      FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Products

      FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Products

      According to the agency, these products are promoted as hormone products or alternatives to anabolic steroids.
      05.18.22

    • Herbs & Botanicals | Research
      Beyond CBD: Cannabis Compounds Warrant Recognition and More Research

      Beyond CBD: Cannabis Compounds Warrant Recognition and More Research

      With growing consumer usage, scientists must continue exploring the many constituents of cannabis, their interactions, and potential health effects.
      By Sean Moloughney, Editor 04.14.22


    • Cardiovascular Health | Dietary Supplements | Digestive Health | Herbs & Botanicals | Minerals | Probiotics & Prebiotics
      Digestive, Gut Health Solutions Offer Downstream Benefits

      Digestive, Gut Health Solutions Offer Downstream Benefits

      Unique ingredients and understanding of their mechanisms can help formulators deliver products that address numerous pain points.
      By Sean Moloughney, Editor 04.14.22

    • Dietary Supplements | Healthcare Trends | Herbs & Botanicals | Minerals | Probiotics & Prebiotics | Women's Health
      Bridging Gaps in Women’s Health with Renewed Attention

      Bridging Gaps in Women’s Health with Renewed Attention

      Women have unique health needs throughout their lives that nutritional products can help to address.
      By Sean Moloughney, Editor 04.14.22

      Trending
      • Leaven Essential To Launch Branded Botanical Extracts To Global Markets | Nutraceuticals World
      • Oregon Files Lawsuit Against GNC | Nutraceuticals World
      • Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk In Older Adults | Nutraceuticals World
      • Coca-Cola To Phase Out Honest Tea Brand By Year’s End, Citing Supply Chain Challenges | Nutraceuticals World
      Breaking News
      • Thorne Relaunches Gut Health Test with Microbiome Wipe
      • Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports
      • GC Rieber Foundations Expand Philanthropic Efforts
      • Danone Celebrates 10th anniversary of Grant Program for Probiotics Research
      • Stratum Nutrition’s Patent Portfolio Grows to Europe and Canada
      View Breaking News >
      CURRENT ISSUE

      May 2022

      • Aging in Place: Lifestyle Supplements Science-Based Solutions
      • Getting an Edge in Esports: Meeting Health & Nutrition Needs
      • Nutraceuticals for Men: Muscle Health and Performance Nutrition

      Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
      You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

      • About Us
      • Privacy Policy
      • Terms And Conditions
      • Contact Us

      follow us

      Subscribe
      Nutraceuticals World

      Latest Breaking News From Nutraceuticals World

      Thorne Relaunches Gut Health Test with Microbiome Wipe
      Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports
      GC Rieber Foundations Expand Philanthropic Efforts
      Coatings World

      Latest Breaking News From Coatings World

      ICP Receives ASC Innovation Award for Spray Foam That Meets Changing Environmental Regulations
      Pylon Coatings Uses Polygiene Biomaster & Verimaster for Antimicrobial Surface Protection
      Sto Corp. Recognized with Multiple Honors at the EIFS Hero Awards
      Medical Product Outsourcing

      Latest Breaking News From Medical Product Outsourcing

      In Vitro Diagnostic Medical Devices Regulation Takes Effect
      Brian Case Appointed Chief Technology Officer at KORU Medical
      Solid Growth Expected for India's Medical Device Sector
      Contract Pharma

      Latest Breaking News From Contract Pharma

      DFE Pharma Opens India CoE for Fast-Track Formulation Services
      Helsinn Establishes New R&D Hub in the U.S.
      CureVac, myNEO Partner on Antigen Targets for mRNA-Cancer Vax Development
      Beauty Packaging

      Latest Breaking News From Beauty Packaging

      Carlyle To Acquire HCP Packaging
      Estée Lauder Companies Faces Class Action Lawsuit
      La Roche-Posay Launches Matte Moisturizer for Oily Skin
      Happi

      Latest Breaking News From Happi

      Acme-Hardesty Passes Responsible Distribution Verification
      Gillette Patents Liquid Hair Removal Composition
      L'Oréal Patents Curly Hair Care Composition
      Ink World

      Latest Breaking News From Ink World

      NAPIM’s Virtual Digital & Emerging Technologies Conference is Back, June 14–15, 2022
      CEMATEX Introduces Online Business Platform to Connect Global Textile Community
      PICO Chemical Celebrates 46 Years
      Label & Narrow Web

      Latest Breaking News From Label & Narrow Web

      Zeller+Gmelin named Berry Global’s 2021 Ink Supplier of the Year
      Videojet and Loftware partner to accelerate labeling automation
      Scratch Off Systems acquires HP Indigo 7K digital press
      Nonwovens Industry

      Latest Breaking News From Nonwovens Industry

      Rael Raises $35M in Series B Funding
      Schobertechnologies Offers Rotary Web-fed Converting Solutions
      Thorne Relaunches Gut Health Test with Microbiome Wipe
      Orthopedic Design & Technology

      Latest Breaking News From Orthopedic Design & Technology

      Emovi, Geneva Foundation Providing Knee Treatment Tech to U.S. Army
      Study Confirms Knee Shapes are Highly Individualized
      Stryker Launches EasyFuse Dynamic Compression for Foot & Ankle
      Printed Electronics Now

      Latest Breaking News From Printed Electronics Now

      ams OSRAM Introduces New Horticulture LEDs
      Avery Dennison Launches AD Twist U7XM Inlays
      ARPA-E Funding Drives Innovation, Industry Partnerships at NREL

      Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

      AD BLOCKER DETECTED

      Our website is made possible by displaying online advertisements to our visitors.
      Please consider supporting us by disabling your ad blocker.


      FREE SUBSCRIPTION Already a subscriber? Login