Effects were investigated in a randomized, double-blind, placebo-controlled, parallel-design study in healthy individuals. A daily dose of 100 mg or 300 mg Careless was compared to placebo after supplementation for 4 weeks.
100 mg Careless improved microcirculation and confirmed results of the first human study, according to the company.
300 mg Careless reduced postprandial glucose levels accompanied by significantly lower HbA1c values compared to baseline. Furthermore, 300 mg Careless intake significantly improved postprandial endothelial function in individuals with decreased endothelial function after high-dose glucose intake.
Dose-depending effects support the use of Careless in different applications, said Dr. Sybille Buchwald-Werner, managing director at Vital Solutions. For example, Careless at a dosage of 100 mg is interesting for products positioned for cardiovascular health or to support physical energy and endurance. Careless at a dosage of 300 mg might be beneficial for use in concepts for healthy metabolism.
The study is published in Planta Medica, one of the leading international, peer-reviewed journals in the field of medicinal plants and natural products.
Careless is a high quality, sustainable natural ingredient, which is IP protected and approved to be used in foods and food supplements.