• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Fueling Cognitive Health through Nutrition & Supplementation

    2020 State of the Industry: High Expectations

    2020 International Buyers' Guide

    Clean Label Questions: Anything But ‘Short and Sweet’

    Key Trends in Functional Foods & Beverages for 2020
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Live From Shows
    Top News
    Deerland Obtains Certification from Australia’s Therapeutic Goods Administration

    OptiMSM Shown to Improve Hair & Nail Appearance and Condition

    DCC Acquires Contract Manufacturer Ion Laboratories

    AquaCelle Delivery Technology Shown to Improve Omega-3 Absorption

    Mintel Identifies Global Food and Drink Trends Over Next 10 Years
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    OptiMSM Shown to Improve Hair & Nail Appearance and Condition

    AquaCelle Delivery Technology Shown to Improve Omega-3 Absorption

    Cannabinoid Testing & Quality: Michael Poleselli on the VivAssure Standard

    Mood33 to Introduce Hemp-Infused Herbal Teas Featuring Evo Hemp

    Elixinol Gains USDA Organic Certification for CBD Tincture
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    OptiMSM Shown to Improve Hair & Nail Appearance and Condition

    DCC Acquires Contract Manufacturer Ion Laboratories

    AquaCelle Delivery Technology Shown to Improve Omega-3 Absorption

    Mintel Identifies Global Food and Drink Trends Over Next 10 Years

    Cannabinoid Testing & Quality: Michael Poleselli on the VivAssure Standard
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Pharmactive Affron Saffron May Help Relieve Depression Symptoms

    Maternal 5-MTHF Levels Predict Fetal Folate Status

    Obesity and Gum Disease May Have Common Connection: Inflammation

    Probiotic Strain Shown to Reduce Symptoms of Infant Colic

    Clinical Trial Confirms Joint Health Benefits of NEM Brand Eggshell Membrane in 7 Days
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    ExcelVite Sdn. Bhd.

    Aiya America (Matcha by Aiya)

    Bioenergy Life Science, Inc. (BLS)

    BatchMaster Software, Inc.

    MitoCarn (Alfasigma)
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    ExcelVite Sdn. Bhd.

    Sabinsa Corporation

    Bioenergy Life Science, Inc. (BLS)

    Aiya America (Matcha by Aiya)

    MitoCarn (Alfasigma)
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • eBook
    • Infographics
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Vitamin B3 May Play A Role In Healthy Aging

    Research links NIAGEN nicotinamide riboside to a more youthful metabolism.

    Related CONTENT
    • ChromaDex Appoints Steve Allen as Chairman
    • ChromaDex Reveals License and Supply Agreement for Suntava Purple Corn
    • Driv Offers Energy for Athletes
    • ChromaDex Enters Retail Commercialization Deal With BPI Sports
    • NARB Recommends Novartis/GSK Discontinue Benefiber Claim: ‘Helps Maintain Regularity’
    10.11.16
    ChromaDex Corp. unveiled results from three studies, including its first human clinical trial, which have been collectively published in journal, Nature Communications.
     
    The team of researchers headed by Charles Brenner, PhD, the Roy J. Carver Chair of Biochemistry at the University of Iowa Carver College of Medicine, demonstrated that NIAGEN nicotinamide riboside (NR) increases production of a metabolite responsible for cellular energy production called NAD+ in mice and humans. These findings may give us a clue as to how we might help ourselves enjoy longer and healthier lives.
     
    NAD+ activates cellular metabolism and energy production within the “powerhouses of the cell”, the mitochondria. Our mitochondria are constantly working to convert calories from food into the energy necessary to power all bodily systems, as well as help us stay healthy enough to ward off illness. This is why NAD+ needs to continuously be replenished in the body. The challenge is that both NAD+ levels and mitochondrial function decline as we age. This reduction in NAD+ is believed by scientists to be linked to a wide variety of age-related conditions.
     
    NR boosts NAD+ production and utilization better than other forms of vitamin B3
    The benefits of NR remained unknown for years after its initial identification in the 1940’s because scientists did not realize there was a way for it to boost NAD+ levels in humans. In 2004, then a faculty member at Dartmouth, Dr. Brenner discovered the enzymes in humans that enable NR to increase NAD+ and identified it as a vitamin. This discovery also suggested that NR had the ability to boost NAD+ in a safe and more efficient way than can be achieved with its B3 cousins, niacin or nicotinamide, giving the body extra energy to focus on its critical needs. Despite more than 75 years of human use of niacin and more than a decade of preclinical work on NR, a quantitative head-to-head-to-head comparison of the three NAD+ precursor vitamins had never been conducted to validate this hypothesis.
     
    In this latest published research, Dr. Brenner and his team—along with collaborators at Queens University Belfast and ChromaDex— demonstrated that NR is not only effective at safely increasing NAD+ metabolism in people but also showed that NR produces a greater increase in liver NAD+ as well as in longevity-promoting sirtuin activities than the other B3 vitamins in mice. “We obtained convincing evidence that oral supplementation of NR boosts NAD+ and enhances the body’s utilization of NAD+ to a greater degree than the familiar forms of vitamin B3. NR is the most efficient NAD+ precursor,” Dr. Brenner shared.
     
    Further hypotheses were validated in his study of 12 healthy men and women who were given three doses of NR: 100 mg, 300 mg and 1000 mg. The results indicated that 24 hours after taking any single dose of NR, blood NAD+ was safely elevated.
    According to ChromaDex’s Founder and CEO, Frank Jaksch, “These results are highly significant because the degree of NAD+ boosting with reported health benefits in mice has been translated in people with an orally supplemented NR. This validates NR as the most efficient NAD+ precursor, and one that does not cause flushing or inhibit the activity of sirtuins.”
     
    Asked about his thoughts on the research results, Mr. Jaksch commented, “Dr. Brenner is the world’s leading expert on NAD+ metabolism, which is why we felt he needed to lead this research and serve on our Scientific Advisory Board. His innovative work is what started the tremendous interest in NR and NAD+ precursors.  This is yet another valuable contribution from Dr. Brenner’s lab which pushes the NR and NAD+ fields of study forward. We expect to see additional published findings from his group in the near future.”
     
    Unexpected findings that excite the experts
    A distinct strength of the Dr. Brenner group is the development of targeted quantitative metabolomic technologies—the simultaneous measurement of the effects of NR, exercise or other interventions on metabolism. In the first of his three studies Dr. Brenner was surprised to find that a low level metabolite called NAAD increased 45-fold as human NAD+ rose in response to NR. This increase signaled that NAAD could be a biomarker of increased NAD+ formation. His second study confirmed this hypothesis while also demonstrating that NAAD is formed from NR. Following NAAD showed that even tissues such as the heart that keep tight control over the total amount of NAD+ have an increase in NAD+ metabolism when NR is supplemented. “NAAD is a reliable biomarker of increased NAD+ metabolism,” explained Dr. Brenner. “The more NAD+ produced, the more we see the NAAD biomarker.”
     
    By following an additional metabolite that is produced when the sirtuin longevity proteins utilize NAD+, Dr. Brenner demonstrated that NR has great advantages over niacin and nicotinamide in activating these proteins in the body. This finding is significant, as many scientists believe sirtuin activation plays an important role in living longer and healthier throughout our lifetime.
     
    What this means in terms of our health and energy
    Though larger increases in NAD+ metabolism were observed at higher doses, the study was significant in showing that lower doses were also effective. Daily NR supplementation—now widely available—safely helps to replenish NAD+ levels. “Maintaining a more youthful metabolism could mean higher resting metabolic rate, resistance to weight gain, and the ability to maintain muscle mass and resist tissue damage over time,” added Dr. Brenner. Results from 9 additional collaborative human trials currently underway should provide additional insights as to the critical role NAD+ plays in people.
     
    For more information: www.Chromadex.com
    Related Searches
    • Healthy Aging
    • Research
    • Vitamins
    Related Knowledge Center
    • Research
    • Healthy Aging
    • Vitamins
    Suggested For You
    NAD Refers Advertising for BodyArmor Sports Drinks to FTC NAD Refers Advertising for BodyArmor Sports Drinks to FTC
    Jelly Belly Supports ‘Clinically Proven’ Claims for Sports Beans Jelly Belly Supports ‘Clinically Proven’ Claims for Sports Beans
    NAD Challenges Certain Claims for Fit Tea Product NAD Challenges Certain Claims for Fit Tea Product
    ChromaDex Adds AnthOrigin to Ingredient Portfolio ChromaDex Adds AnthOrigin to Ingredient Portfolio
    NAD Recommends Mars Modify Certain Claims for CocoaVia Cocoa Extract NAD Recommends Mars Modify Certain Claims for CocoaVia Cocoa Extract
    Natreon’s PrimaVie Shown to Up-Regulate Genes Responsible for Collagen Synthesis Natreon’s PrimaVie Shown to Up-Regulate Genes Responsible for Collagen Synthesis
    ChromaDex Adds to Executive Team ChromaDex Adds to Executive Team
    Can More Fiber Restore Microbiome Diversity? Can More Fiber Restore Microbiome Diversity?
    Barentz and Parabel Partner on Global Distribution of LENTEIN Plant Protein Barentz and Parabel Partner on Global Distribution of LENTEIN Plant Protein
    Obesity-Related Clinical Study of NIAGEN Commences Obesity-Related Clinical Study of NIAGEN Commences
    NARB Recommends Novartis/GSK Discontinue Benefiber Claim: ‘Helps Maintain Regularity’ NARB Recommends Novartis/GSK Discontinue Benefiber Claim: ‘Helps Maintain Regularity’
    ChromaDex Enters Retail Commercialization Deal With BPI Sports ChromaDex Enters Retail Commercialization Deal With BPI Sports
    Driv Offers Energy for Athletes Driv Offers Energy for Athletes
    ChromaDex Reveals License and Supply Agreement for Suntava Purple Corn ChromaDex Reveals License and Supply Agreement for Suntava Purple Corn
    ChromaDex Appoints Steve Allen as Chairman ChromaDex Appoints Steve Allen as Chairman

    Related Breaking News

    • Breaking News | Cosmeceuticals / Nutricosmetics | Minerals | Research | Research News | Supplier News
      OptiMSM Shown to Improve Hair & Nail Appearance and Condition

      OptiMSM Shown to Improve Hair & Nail Appearance and Condition

      Mechanism could be that MSM provides sulfur to keratin, helping strengthen keratin molecule bonds in hair and nails.
      12.10.19

    • Breaking News | Delivery & Dosage Technologies | Omega-3s | Research | Research News | Supplier News
      AquaCelle Delivery Technology Shown to Improve Omega-3 Absorption

      AquaCelle Delivery Technology Shown to Improve Omega-3 Absorption

      Published clinical trial indicated six-fold increase in total absorption of EPA and DHA ethyl esters compared to control.
      12.10.19

    • Breaking News | Herbs & Botanicals | Mood Health & Sleep | Research | Research News | Supplier News
      Pharmactive Affron Saffron May Help Relieve Depression Symptoms

      Pharmactive Affron Saffron May Help Relieve Depression Symptoms

      Extract combined with antidepressant drugs led to 41% decrease in depressive symptoms after eight weeks.
      12.05.19


    • Breaking News | Infant & Children's Health | Research | Research News | Supplier News | Vitamins | Women's Health
      Maternal 5-MTHF Levels Predict Fetal Folate Status

      Maternal 5-MTHF Levels Predict Fetal Folate Status

      Study evaluated effect of race and supplementation on maternal and umbilical cord plasma folate.
      12.05.19

    • Breaking News | Inflammation | Oral Health | Research | Research News | Weight Management/Weight Loss
      Obesity and Gum Disease May Have Common Connection: Inflammation

      Obesity and Gum Disease May Have Common Connection: Inflammation

      Healthcare professionals should counsel patients about maintaining healthy body weight and performing good oral hygiene procedures.
      12.05.19

    • Breaking News | Infant & Children's Health | Probiotics & Prebiotics | Research | Research News
      Probiotic Strain Shown to Reduce Symptoms of Infant Colic

      Probiotic Strain Shown to Reduce Symptoms of Infant Colic

      Crying was reduced by half, and beneficial effects seen in sleep duration and stool frequency/consistency.
      12.05.19


    • Bone & Joint Health | Breaking News | Minerals | Research | Research News | Supplier News
      Clinical Trial Confirms Joint Health Benefits of NEM Brand Eggshell Membrane in 7 Days

      Clinical Trial Confirms Joint Health Benefits of NEM Brand Eggshell Membrane in 7 Days

      By day 30, both knee pain and stiffness had improved by more than 30% in the NEM-treated subjects.
      12.05.19

    • Breaking News | Cognitive Function | Healthy Aging | Research | Research News
      High Intake of Nuts May Help Protect Older Adults from Cognitive Decline

      High Intake of Nuts May Help Protect Older Adults from Cognitive Decline

      Study on Italian cohort indicated nut consumption associated with lower cognitive decline based on Mini-Mental State Examination test.
      12.03.19

    • Breaking News | Certifications, Approvals & Patents | Supplier News | Vitamins | World Markets

      ChromaDex Gains TGA Approval for Nicotinamide Riboside Chloride in Australia

      Company receives market exclusivity for two years as it expands presence in the Asia-Pacific region.
      12.03.19


    • Breaking News | Healthy Aging | Supplier News
      IFF Health to Enter Strategic Collaboration With BY-HEALTH to Focus on Healthy Aging

      IFF Health to Enter Strategic Collaboration With BY-HEALTH to Focus on Healthy Aging

      Companies to research the production and international development of science-based ingredient formulations.
      11.26.19

    • Breaking News | Healthcare Trends | Industry & Market News | Infant & Children's Health | Omega-3s | Vitamins
      IADSA Includes Omega-3s and Folic Acid in ‘Mind the Gap’ Resource Campaign

      IADSA Includes Omega-3s and Folic Acid in ‘Mind the Gap’ Resource Campaign

      Initiatives designed to change the way companies communicate positive stories about supplements.
      11.19.19

    • Breaking News | Proteins, Peptides, Amino Acids | Supplier News | Vitamins

      Parabel Identifies Bioactive Vitamin B12 in Water Lentils and LENTEIN Plant Protein

      Company to conduct bioavailability studies to determine effectiveness of water lentils as a natural, plant-based solution to address vitamin B12 deficiencies.
      11.19.19

    • Breaking News | Healthcare Trends | Immune Function | Industry & Market News | Research
      Ketogenic Diet May Fuel Immune System to Fight Flu Virus

      Ketogenic Diet May Fuel Immune System to Fight Flu Virus

      In a mouse study, keto diet triggered the release of gamma delta T cells, immune system cells that produce mucus in the cell linings of the lung.
      11.19.19

    • Antioxidants | Breaking News | Cardiovascular Health | Herbs & Botanicals | Research | Research News | Supplier News
      Animal study Demonstrates Cardioprotective Benefits of Sabinsa’s Pterostilbene

      Animal study Demonstrates Cardioprotective Benefits of Sabinsa’s Pterostilbene

      Silbinol led to reduction of TMAO formation and decreased vascular inflammation.
      11.19.19

    • Breaking News | Cardiovascular Health | Research | Research News | Supplier News | Vitamins

      Vitamin K2 as MK-7 Shown to Improve Endothelial Function

      MenaQ7 mouse study advances argument of K2 as MK-7 as a cardio-protective nutrient by highlighting new pharmacological activity.
      11.15.19

    Breaking News
    • Deerland Obtains Certification from Australia’s Therapeutic Goods Administration
    • OptiMSM Shown to Improve Hair & Nail Appearance and Condition
    • DCC Acquires Contract Manufacturer Ion Laboratories
    • AquaCelle Delivery Technology Shown to Improve Omega-3 Absorption
    • Mintel Identifies Global Food and Drink Trends Over Next 10 Years
    View Breaking News >
    CURRENT ISSUE

    December 2019

    • 2020 International Buyers' Guide
    • 2020 State of the Industry: High Expectations
    • Fueling Cognitive Health through Nutrition & Supplementation
    • View More >
    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Deerland Obtains Certification from Australia’s Therapeutic Goods Administration
    OptiMSM Shown to Improve Hair & Nail Appearance and Condition
    DCC Acquires Contract Manufacturer Ion Laboratories
    Coatings World

    Latest Breaking News From Coatings World

    Arkema: Bostik Acquires Danish Company LIP
    Axalta Adds New Epoxy Primer to Tufcote Liquid Industrial Coatings Portfolio
    Chromaflo Technologies Promotes Sergio Duenas to Country Manager of Mexico
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    FDA OKs World's First Single-Use Duodenoscope
    Dr. Stephen Hahn Confirmed as New FDA Leader
    FDA OKs First Test to Help Screen for Newborn Duchenne Muscular Dystrophy
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Sanofi Awarded $226M by US Gov't for Pandemic Influenza Preparedness
    Amgen Selects Location For R&D Facility
    Arctoris Opens Oxford R&D Facility
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Time Features 5 Best Beauty Inventions
    CES 2020 Preview - Innovation Award Honorees in Health & Wellness
    Prada & L’Oréal Sign Long-Term Licensing Deal
    Happi

    Latest Breaking News From Happi

    Cosmetic Assessments Revealed at CIR Panel
    T-Boz Launches CBD Line
    DRF and Flowerkist Develop CBD Range
    Ink World

    Latest Breaking News From Ink World

    Ripon Printers Adds Ricoh Pro C9210
    LogoJet Opens Bogota, Colombia Office
    Canon Solutions America Powers University of Notre Dame Athletics' Printing Capabilities
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    GSE products provide quality assurance for Pharmalabel
    Luminer promotes Heather Bookman to prepress manager
    Materials Exchange launches to solve excess inventory issue
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    DuPont to Acquire Osmosis Specialist
    Nice-Pak to Expand in Indiana
    Hospeco Launches Compact Fem Hy Dispenser
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    FDA OKs First Test to Help Screen for Newborn Duchenne Muscular Dystrophy
    Europe, North America Comprise More Than 80 Percent of Global Bone Marrow Transplantation Demand
    TriMed Closes Out FDA Warning Letter
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    3D Printing Materials Market to Grow at 23.9% CAGR Through 2025: GVR
    Kyocera, TactoTek Collaborate on Injection Molded Structural Electronics Solutions
    Toray Opens R&D Innovation Center for the Future

    Copyright © 2019 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.