The randomized trials submitted to the Canadian authorities included a total of 330 children and 52 adults showing the following conclusions:
- Jindal et al. (2011): Oralis SB significantly reduces salivary S. mutans count as compared to a placebo in children. The authors concluded that Oralis SB“might be used as a suitable, easy and safe method for anti-caries prevention.”
- Jothika et al. (2015): Oralis SB used as mouthwash significantly reduces the count of cariogenic bacteria S. mutans found in the plaque in adults as compared to placebo and with similar efficacy than traditional antiseptic solutions (chlorhexidine and sodium fluoride mouthwashes).
- Thakkar et al., (2013): Oralis SB significantly reduces dental plaque formation in children, when compared to placebo, but also to chlorhexidine antiseptic mouthwash. It was concluded that Oralis SB “can be viewed as potential alternative to chlorhexidine mouthrinse for prevention of periodontal disease."
- Purunaik et al. (2014): Oralis SB significantly reduces dental plaque formation in children as compared to placebo and chlorhexidine, and is even significantly more effective than chlorhexidine on gingivitis.