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    Features

    The Science of Cannabis & Cannabinoids

    Demand for Cannabis-based products is reaching fever-pitch.

    The Science of Cannabis & Cannabinoids
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    By Dilip Ghosh, PhD, FACN, nutriConnect09.10.18
    The cannabis plant, which may be different species (principally Cannabis sativa and Cannabis indica) or variants of the same species, is a dioecious entity and contains a number of unique resorcinol metabolites—estimates vary from 60-110. The most recognizable cannabinoid metabolite is delta-9-tetrahydrocannabinol (THC). Recent published data described the pharmacology of two other agents, cannabidiol (CBD) and delta-9-tetrahydrocannabivarin (THCV), and concluded that these compounds exhibited complex interactions with the human endocannabinoid system. Apart from these three compounds, other cannabinoids that have shown pharmacological effects include cannabigerol, cannabidivarin, cannabidiolic acid, and cannabichromene.

    Evidence of cannabis use for medical purposes can be traced back to 2737 BCE in ancient China. Since then there have been wide variations in the use and acceptance of cannabis as a drug therapy in Western medicine. In 1999, California was the only U.S. state that allowed patients to access cannabis for medicinal purposes. By 2016, there were 24 states where cannabis was available as a therapeutic agent, and three that had approved cannabis for

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