03.05.18
A new randomized trial published online in the British Medical Journal Gut found evidence that calcium supplementation and the combination of calcium and vitamin D may increase the risk of serrated polyps during later follow-up—specifically sessile serrated adenomas or polyps (SSA/Ps), which are important colorectal cancer precursors—among patients with a history of colorectal polyps.
The increased risk appeared to be a late effect (6-10 years after supplementation began), according to the study. Authors said further research is recommended to confirm these results, which may have important implications for screening and prevention. And these possible risks must be weighed against the benefits of calcium and vitamin D supplementation.
Study Design
For this study, participants with one or more adenoma at baseline were randomized to receive 1,200 mg/day of elemental calcium, 1,000 IU/day of vitamin D3, both or neither agent. Treatment continued for 3 or 5 years, when risk of polyps was determined from surveillance colonoscopy (treatment phase). Outcomes a
The increased risk appeared to be a late effect (6-10 years after supplementation began), according to the study. Authors said further research is recommended to confirm these results, which may have important implications for screening and prevention. And these possible risks must be weighed against the benefits of calcium and vitamin D supplementation.
Study Design
For this study, participants with one or more adenoma at baseline were randomized to receive 1,200 mg/day of elemental calcium, 1,000 IU/day of vitamin D3, both or neither agent. Treatment continued for 3 or 5 years, when risk of polyps was determined from surveillance colonoscopy (treatment phase). Outcomes a
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