AB Biotek has launched adiDAO Microencapsulated, a new ingredient format that optimizes the delivery of diamine oxidase (DAO), a digestive enzyme that helps the body break down dietary histamine, which is found in high concentrations in certain foods like dairy, fish, cheese, and wine. The new format also enables DAO to be combined with other functional ingredients for the first time.
 
Increased levels of unmetabolized histamine in the blood may result a multitude of symptoms, and DAO deficiency is one of the most common enzyme-related metabolic disorders, according to the company.
 
DAO is sensitive to stomach pH, necessitating the use of resistant delivery mechanisms. DAO also interacts with other bioactive ingredients in a way that diminishes its benefits.
 
The latest innovation microencapsulates DAO by two food-grade protective layers using a combination of coating technologies. These layers are designed to protect the DAO, optimizing its delivery when it reaches the small intestine. The layers also protect against undesirable interactions.
 
The delivery platform is compatible with probiotics or prebiotics in supplements, as well as in combinations with various pharmaceutical actives in different concentrations. adiDAO Microencapsulated is also suitable for tablets, stick packs, liquid suspensions, gummies, and capsules. The new delivery platform also results in a simplified production process and reduced manufacturing costs compared to traditional coating methods.
 
“Rising awareness of DAO deficiency and related health issues is driving demand for innovative new solutions using DAO,” said Gerald Dard, managing director at AB Biotek HNH. “Our adiDAO microencapsulated break new ground in this growing market, allowing manufacturers to combine other actives directly with DAO for the first time. It’s not just a flexible solution, but also a major technological leap forward with the potential to improve real outcomes for the many people affected by DAO deficiency.”