06.30.21
A recent clinical trial published in the journal Nutrients provided evidence that Hyaluronan, a natural ingredient found in soft connective tissues, could achieve wrinkle reduction and skin hydration benefits that would normally be seen in the ingredient’s topical use. The trial showed that similar benefits could be conferred to the ingredient’s use as a beauty-from-within product in its ingestible form.
“Hyaluronan is present in all connective tissues and organs, including the skin and joint fluid. However, few clinical trials have comprehensively evaluated the impacts of oral HA on skin conditions, including wrinkles and moisturization,” the authors of the study said.
In the present study, which was supported by Kewpie Corporation’s R&D Division, Taiwanese researchers from Hung Kuang University and Providence University administered a daily supplement containing 120 mg of hyaluronan to 40 healthy Asian men and women between the ages of 35 and 64 for 12 weeks, in a double-blind, placebo-controlled design.
The researchers utilized a variety of measurements in order to assess the overall skin health of the participants both at baseline and throughout the trial period – these measurements included skin hydration and barrier function, skin elasticity, skin structure, and facial photography.
The authors of the study noted significant differences achieved following just eight weeks of supplementation, in the areas of skin hydration measurements and wrinkle reduction, compared to the placebo, substantiating that hyaluronan can be metabolized and exert similar benefits to skin health that would be seen in topical applications.
“Surgical techniques (e.g. injection of hyaluronic acid fillers), topical agents, cosmetics, and health functional foods are currently utilized for the anti-aging treatment of the skin and improvement of dry skin. Surgical techniques offer immediate results; however, they are expensive and associated with a risk of pain and swelling,” the authors wrote. “Topical drugs and cosmetic creams are relatively inexpensive treatment options. Nevertheless, they exert limited effects on the site of application…”
The authors stated that this study on the ingestion of hyaluronan is the first of its kind.
“…Thus far, no human study has comprehensively evaluated the impacts of HA ingestion on the skin, including skin hydration, skin barrier function, skin elasticity, skin structure, and facial photography,” the authors said.
“Hyaluronan is present in all connective tissues and organs, including the skin and joint fluid. However, few clinical trials have comprehensively evaluated the impacts of oral HA on skin conditions, including wrinkles and moisturization,” the authors of the study said.
In the present study, which was supported by Kewpie Corporation’s R&D Division, Taiwanese researchers from Hung Kuang University and Providence University administered a daily supplement containing 120 mg of hyaluronan to 40 healthy Asian men and women between the ages of 35 and 64 for 12 weeks, in a double-blind, placebo-controlled design.
The researchers utilized a variety of measurements in order to assess the overall skin health of the participants both at baseline and throughout the trial period – these measurements included skin hydration and barrier function, skin elasticity, skin structure, and facial photography.
The authors of the study noted significant differences achieved following just eight weeks of supplementation, in the areas of skin hydration measurements and wrinkle reduction, compared to the placebo, substantiating that hyaluronan can be metabolized and exert similar benefits to skin health that would be seen in topical applications.
“Surgical techniques (e.g. injection of hyaluronic acid fillers), topical agents, cosmetics, and health functional foods are currently utilized for the anti-aging treatment of the skin and improvement of dry skin. Surgical techniques offer immediate results; however, they are expensive and associated with a risk of pain and swelling,” the authors wrote. “Topical drugs and cosmetic creams are relatively inexpensive treatment options. Nevertheless, they exert limited effects on the site of application…”
The authors stated that this study on the ingestion of hyaluronan is the first of its kind.
“…Thus far, no human study has comprehensively evaluated the impacts of HA ingestion on the skin, including skin hydration, skin barrier function, skin elasticity, skin structure, and facial photography,” the authors said.
