• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Reinforcing Omega-3 Supply Networks

    A Clearer Path to Weight Management: The Ozempic Factor

    Under Pressure: Stress and Mental Health Have Taken Center Stage

    Sustainable Business Development: Principles and Strategies for Progress

    Beauty IO MarketWatch: L’Oréal to Define the Next Era of Beauty Tech in CES 2024 Keynote
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Glossary
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    D2C Supplement Brand Launches Blood Sugar Support Supplement, Gluco-Control

    Natrol Launches First Non-Melatonin Sleep Supplement

    Metagenics Releases Consumer Survey on Menopausal Support Supplement

    Culturelle Probiotics Launches Women’s Health Awareness Campaign

    Women's Health Brand O Positiv Launches Essentials Line of Supplements
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    D2C Supplement Brand Launches Blood Sugar Support Supplement, Gluco-Control

    Natrol Launches First Non-Melatonin Sleep Supplement

    Metagenics Releases Consumer Survey on Menopausal Support Supplement

    Women's Health Brand O Positiv Launches Essentials Line of Supplements

    Growing Mushrooms At Home With Mistercap, Wiz Khalifa
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    D2C Supplement Brand Launches Blood Sugar Support Supplement, Gluco-Control

    Natrol Launches First Non-Melatonin Sleep Supplement

    Metagenics Releases Consumer Survey on Menopausal Support Supplement

    Culturelle Probiotics Launches Women’s Health Awareness Campaign

    Women's Health Brand O Positiv Launches Essentials Line of Supplements
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    D2C Supplement Brand Launches Blood Sugar Support Supplement, Gluco-Control

    Natrol Launches First Non-Melatonin Sleep Supplement

    Metagenics Releases Consumer Survey on Menopausal Support Supplement

    Culturelle Probiotics Launches Women’s Health Awareness Campaign

    Women's Health Brand O Positiv Launches Essentials Line of Supplements
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Xsto Solutions

    Bioenergy Life Science, Inc. (BLS)

    American FlexPack

    BGG World

    JRS Pharma
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Xsto Solutions

    Bioenergy Life Science, Inc. (BLS)

    American FlexPack

    BGG World

    JRS Pharma
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Annatto Tocotrienol May Improve Fatty Liver Index in Patients with Non-Alcoholic Fatty Liver Disease

    DeltaGold tocotrienol led to decreased biochemical levels and metabolic factors associated with fatty liver.

    05.22.18
    Delta-tocotrienol from annatto decreased biomarkers associated with fatty liver, according to a clinical study in patients diagnosed with non-alcoholic fatty liver disease (NAFLD).
     
    A recent study conducted at the Armed Forces Institute of Pathology in Pakistan, published in the Turkish Journal of Gastroenterology, added new data to a growing body of evidence that showed tocotrienol benefits for the liver. Results of the 12-week randomized, double-blind, placebo-controlled trial of the patented DeltaGold annatto-derived tocotrienol ingredient by American River Nutrition, Inc. indicated significant efficacy on the fatty liver index score and other liver-related biomarkers in NAFLD patients. This is the first-ever clinical trial using tocotrienols only (without the presence of tocopherols) in NAFLD, according to American River.
     
    In the 12-week study of 71 NAFLD patients, DeltaGold tocotrienol was administered at a dosage of 600 mg/day (300 mg twice daily), which led to decreased biochemical levels and metabolic factors associated with fatty liver. This was compared to a blinded and placebo group. All patients were advised to eat a fat-reduced diet and perform regular physical activity.
     
    NAFLD occurs when excess fat is stored in the liver, and is most commonly associated with obesity and metabolic syndrome. According to the National Institute of Health, NAFLD is estimated to affect 30-40% of U.S. adults, and can transition to the more serious non-alcoholic steatohepatits (NASH) in 20% of these cases. Complications of the disease include liver fibrosis, cirrhosis, and liver cancer, with progressive cases requiring liver transplants. Currently, there is no pharmacological treatment for NAFLD, and changes in diet and exercise are the standard of care. Natural alternatives may provide safe and effective treatment for NAFLD.
     
    Liver biomarkers that were examined included serum aminotransferases (ALT, AST) and gamma-glutamyl transferase (GGT), while inflammatory high-sensitivity C-reactive protein (hs-CRP), oxidative stress marker malondialdehyde (MDA), and triglycerides were also tested. Physical measures included weight, body mass index (BMI) and waist circumference. The Fatty Liver Index (FLI), which includes measures of weight, BMI, waist circumference, GGT, and triglycerides, was used for predicting fatty liver.
     
    Significant improvements in liver biomarkers indicative of hepatic stress reduction were evident after 12 weeks, with decreases of 15-16% in ALT, AST. Furthermore, significant decreases in triglycerides (11%), MDA (14%), and hs-CRP (18%) were indicative of reduced inflammation and are consistent with results of previous clinical trials conducted with DeltaGold in hypercholesterolemic subjects. Notably, the FLI score decreased a significant 11%, suggesting intrahepatic fat reduction. During the 12-week treatment period, patients in the tocotrienol-supplemented group lost an average of 9.7 pounds. Although ultrasonography was utilized to assess the degree of liver steatosis at the beginning and end of the intervention, the study duration was too short to allow for the extent of intrahepatic fat reduction necessary for radiological detection. FLI, on the other hand, based on biochemical and anthropometric measures, is more sensitive than ultrasonography for detecting therapy response during short intervals.
     
    The authors noted that the study outcomes were very encouraging, providing a platform for future larger-scale clinical trials. They remarked that “these results provide a proof-of-principle for the superiority of delta-tocotrienol, and strongly favor the safe and effective use of this compound for the management of NAFLD in the future.”
     
    Commenting on the research, Dr. Barrie Tan, president of American River Nutrition Inc. said that “delta-tocotrienol’s anti-inflammatory effect—including remarkable decreases in hs-CRP—has now been best indicated in clinical trials for hyperlipidemia, osteopenia, and NAFLD, where annatto tocotrienol consistently reduced inflammation.” Dr. Tan believes this is the first tocotrienol study to show an almost 10-pound weight loss in NAFLD patients, a phenomenon previously undocumented for the supplement. “I look forward to future trials that will further explore the effects of annatto tocotrienol on NAFLD patients, with a larger population, longer duration, and additional diagnostic tools.”
     
    Vitamin E is a family of eight separate but related molecules: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). While alpha-tocopherol is found in most multivitamins and is supplemented in foods, a growing base of evidence suggests this popular vitamin E interferes with the uptake and function of tocotrienols. Tocotrienols are derived from three major sources, including rice, palm and annatto.
    Related Searches
    • Obesity
    • Multivitamins
    • Metabolic Syndrome
    • vitamin e
    Related Knowledge Center
    • Vitamins
    Suggested For You
    CardioMetaboliQ Launches At-Home Blood Test for Cardiometabolic Health CardioMetaboliQ Launches At-Home Blood Test for Cardiometabolic Health
    Curcumin Plays Role in Weight Management, Review Finds Curcumin Plays Role in Weight Management, Review Finds
    Tocotrienols May Have Protective Effect on Liver in NAFLD Patients Tocotrienols May Have Protective Effect on Liver in NAFLD Patients
    Epax Launches Omega-11 Cetoleic Acid Ingredient Epax Launches Omega-11 Cetoleic Acid Ingredient
    Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD
    Vitamin D May Prevent Changes to Liver Enzymes and Lipid Profile After Exhaustive Exercise Vitamin D May Prevent Changes to Liver Enzymes and Lipid Profile After Exhaustive Exercise
    Pre-Clinical Studies Reveal Weight Loss Mechanism of Herbal Formula Pre-Clinical Studies Reveal Weight Loss Mechanism of Herbal Formula
    Can a Simple Vitamin E Keep Cardiometabolic Syndrome at Bay? Can a Simple Vitamin E Keep Cardiometabolic Syndrome at Bay?
    Mitsubishi Receives U.S. Patent for Glutathione Ingredient Mitsubishi Receives U.S. Patent for Glutathione Ingredient
    Sweeteners Market Continues to Broaden with Cleaner Labels and Better Formulations Sweeteners Market Continues to Broaden with Cleaner Labels and Better Formulations
    Study Suggests Added Sugars Can Double Liver Fat Production Study Suggests Added Sugars Can Double Liver Fat Production
    Whole Grains Evidenced to Change Gut Microbiota and Potentially Improve Liver Health Whole Grains Evidenced to Change Gut Microbiota and Potentially Improve Liver Health
    Diets High In Fructose Could Cause Immune System Damage Diets High In Fructose Could Cause Immune System Damage
    Omega-3s Associated with Better Liver Functioning In NAFLD Patients Omega-3s Associated with Better Liver Functioning In NAFLD Patients
    AlgaeHealth AstaZine Natural Astaxanthin Certified as Glyphosate-Free AlgaeHealth AstaZine Natural Astaxanthin Certified as Glyphosate-Free

    Related Breaking News

    • Breaking News | Cardiovascular Health | Diabetes & Blood Sugar Management | Medical Nutrition | Products | Testing
      CardioMetaboliQ Launches At-Home Blood Test for Cardiometabolic Health

      CardioMetaboliQ Launches At-Home Blood Test for Cardiometabolic Health

      The new test includes Fatty Liver Index, and vascular, insulin resistance, and other markers.
      08.28.23

    • Breaking News | Dietary Supplements | Herbs & Botanicals | Research News | Weight Management/Weight Loss
      Curcumin Plays Role in Weight Management, Review Finds

      Curcumin Plays Role in Weight Management, Review Finds

      The botanical was linked to BMI, body weight, and waist circumference reductions in both healthy and diseased populations.
      05.11.23

    • Breaking News | Dietary Supplements | Medical Nutrition | Research | Research News | Vitamins
      Tocotrienols May Have Protective Effect on Liver in NAFLD Patients

      Tocotrienols May Have Protective Effect on Liver in NAFLD Patients

      Delta-tocotrienol from annatto downregulated gene expressions associated with non-alcoholic fatty liver disease in patients.
      02.08.23


    • Breaking News | Cosmeceuticals / Nutricosmetics | Dietary Supplements | Marine Nutraceuticals | Skin Health | Supplier News
      Epax Launches Omega-11 Cetoleic Acid Ingredient

      Epax Launches Omega-11 Cetoleic Acid Ingredient

      Emerging research on the marine lipid indicates possible benefits for skin health.
      10.20.22

    • Breaking News | Inflammation | Research | Research News | Supplier News | Vitamins | Weight Management/Weight Loss
      Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD

      Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD

      Delta-tocotrienol from annatto decreased biomarkers associated with fatty liver disease, according to a published clinical study.
      08.19.22

    Loading, Please Wait..
    Trending
    • Soviets Took Probiotics To The Next Level
    • Todd Spear Joins Protein Research As VP Of Sales And Marketing
    • Growing Mushrooms At Home With Mistercap, Wiz Khalifa
    • New Technology Converts Sugar In Juice To Fiber
    Breaking News
    • D2C Supplement Brand Launches Blood Sugar Support Supplement, Gluco-Control
    • Natrol Launches First Non-Melatonin Sleep Supplement
    • Metagenics Releases Consumer Survey on Menopausal Support Supplement
    • Culturelle Probiotics Launches Women’s Health Awareness Campaign
    • Women's Health Brand O Positiv Launches Essentials Line of Supplements
    View Breaking News >
    CURRENT ISSUE

    September 2023

    • A Clearer Path to Weight Management: The Ozempic Factor
    • Under Pressure: Stress and Mental Health Have Taken Center Stage
    • Sustainable Business Development: Principles and Strategies for Progress
    • BIOHM Health Targets ‘Digestive Plaque’ with Probiotic, Fungus, and Enzyme Formula
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    D2C Supplement Brand Launches Blood Sugar Support Supplement, Gluco-Control
    Natrol Launches First Non-Melatonin Sleep Supplement
    Metagenics Releases Consumer Survey on Menopausal Support Supplement
    Coatings World

    Latest Breaking News From Coatings World

    BASF Donates $5,000 to High School STEAM Education Programs in Chattanooga Area
    Coating Additives Market Worth $10.5B by 2028: MarketsandMarkets
    California Sports Surfaces Celebrates 70 Years
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    MPO's Most-Read Stories This Week—Sept. 30
    Dentsply Sirona Names Former NuVasive CEO Lucier as Chairman
    SeaStar Medical Gets Breakthrough Nod for Selective Cytopheretic Device
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Univercells Expands into the U.S. With New Offices in Andover, MA
    Evecxia Therapeutics, Quotient Sciences Complete Clinical Milestone for Depression Treatment
    Ionis, Roche Partner on RNA-targeted Programs for AD and HD
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    ScentAir Debuts Room Sprays & More
    African Pride Launches On-Campus Activations
    Sharper Image Debuts Revel Hair Tools
    Happi

    Latest Breaking News From Happi

    Hair Searches in the US Change ‘Coarse’ with Growing Demand for Textured Hair Solutions
    Boss Bottled Celebrates 25th Anniversary
    In the Case of Efficacious Cosmetic Buys, Cost is Not A Factor Says Mintel
    Ink World

    Latest Breaking News From Ink World

    W+D to Premiere i-Jet 3 Inkjet at Printing United
    MicroDynamics, All Printing Resources Partner to Represent Veritas
    Weekly Recap: Wikoff Color, BASF, Latin America Top This Week’s Stories
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    TLMI's LLT grows, Labelexpo Europe details big numbers and more
    SABIC and partners launch bio-based IML solution for food packaging
    tesa completes expansion of Michigan manufacturing facility
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Weekly Recap: Thomas Receives INDA Lifetime Technical Service Award, ExxonMobil Works with JL Goor
    Greentech Introduces Air Filter with Advanced Odor Elimination
    Ontex Divests Pakistan Operations to ASAIA Holding
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    ODT's Most-Read Stories This Week—Sept. 30
    Lazurite Adds Benchmark Medical as a Distributor for its ArthroFree Wireless Camera System
    ChitogenX Granted New U.S., Canadian ORTHO-R Patent
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Weekly Recap: Mergers and Acquisitions, First Solar Top This Week’s Stories
    Jabil Posts Fourth Quarter, Fiscal Year 2023 Results
    Ink-Borne ‘Chiplets’ Could Lead to Printable Displays, Electronics and More

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login