The study included an acute phase (0-24 hours, single dose of 180 mg) and an accumulation phase (21 days, daily dose of 60 mg.) During the acute phase, five healthy subjects ingested either: MicroActive CoQ10 hard gelatin capsules, crystalline CoQ10 hard gelatin capsules or oil-solubilized CoQ10 soft gels containing a proprietary absorption enhancer. The study was cross-over in design, so all subjects tested all formulations. During the accumulation phase, 22 healthy subjects were randomly divided into two groups: Group A, assigned MicroActive CoQ10 hard gelatin capsules, and Group B, assigned oil-solubilized CoQ10 soft gels containing a proprietary absorption enhancer.
The results of the acute phase showed that both the MicroActive and the solubilized CoQ10 had significantly better bioavailability than the regular crystalline powder. However, the inter-subject variance was significantly greater in the group taking the solubilized form versus the other two forms. Additionally, the MicroActive CoQ10 complex showed a sustained release.
The results of the accumulation phase demonstrated that the MicroActive group showed higher uptake of CoQ10 compared with the solubilized group. In fact, while 100% of subjects in the MicroActive group doubled their CoQ10 levels after three weeks, only 44% of those in the solubilized group did. For further information: www.maypro.com.