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November 2014 Issue
Last Updated Thursday, November 27 2014
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ISP



Published January 20, 2010
ISP has self-affirmed that its Plasdone K-29/32 and Plasdone K-90 binders, as well as Polyplasdone XL and XL-10 disintegrants are Generally Recognized as Safe (GRAS), following a comprehensive evaluation of research and toxicology studies by a qualified, independent scientific panel. The GRAS status allows for the inclusion in nutritional and supplement products.

Plasdone K-29/32 and Plasdone K-90 binders are linear homopolymers of N-vinyl-2-pyrrolidone. Among other uses, the polymers serve as wet granulation binders. Polyplasdone XL and XL-10 disintegrants are insoluble, crosslinked, homopolymers of N-vinyl-2-pyrrolidone and provide rapid disintegration to wet and dry granulations and direct compression tablet formulations.


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