11.01.03
Indication: Coronary heart disease (CHD)
Source: Am J Cardiol, 2003;92(6):665-669.
Research: The purpose of this study was to examine the relationship between dietary magnesium intake and the future risk of CHD. Reported findings are based on dietary magnesium intake in 7172 men in the Honolulu Heart Program. Intake of magnesium was recorded at baseline examinations, which took place from 1965 to 1968 when the men were aged 45 to 68 years.
Results: In 30 years of follow-up, 1431 incident cases of CHD were identified. Within 15 years after dietary assessment, the age-adjusted incidence decreased significantly from 7.3 to 4.0 per 1000 person-years in the lowest (50.3 to 186 mg/day) versus highest (340 to 1183 mg/day) quintiles of magnesium intake. When adjustments were made for age and other nutrients (singly or combined), there was a 1.7- to 2.1-fold excess in the risk of CHD in the lowest versus highest quintiles. The excess risk ranged from 1.5- to 1.8-fold after further adjustment for other cardiovascular risk factors. Associations between dietary magnesium and coronary events occurring after 15 years of follow-up were modest. Researchers concluded that the intake of dietary magnesium is associated with a reduced risk of CHD. Whether increases in dietary magnesium intake can alter the future risk of disease, however, warrants further study.
Source: Am J Cardiol, 2003;92(6):665-669.
Research: The purpose of this study was to examine the relationship between dietary magnesium intake and the future risk of CHD. Reported findings are based on dietary magnesium intake in 7172 men in the Honolulu Heart Program. Intake of magnesium was recorded at baseline examinations, which took place from 1965 to 1968 when the men were aged 45 to 68 years.
Results: In 30 years of follow-up, 1431 incident cases of CHD were identified. Within 15 years after dietary assessment, the age-adjusted incidence decreased significantly from 7.3 to 4.0 per 1000 person-years in the lowest (50.3 to 186 mg/day) versus highest (340 to 1183 mg/day) quintiles of magnesium intake. When adjustments were made for age and other nutrients (singly or combined), there was a 1.7- to 2.1-fold excess in the risk of CHD in the lowest versus highest quintiles. The excess risk ranged from 1.5- to 1.8-fold after further adjustment for other cardiovascular risk factors. Associations between dietary magnesium and coronary events occurring after 15 years of follow-up were modest. Researchers concluded that the intake of dietary magnesium is associated with a reduced risk of CHD. Whether increases in dietary magnesium intake can alter the future risk of disease, however, warrants further study.