06.25.08
Indication: Prostate cancer
Source: Am J Clin Nutr, April 2008;87(4): 985-92.
Research: Investigators evaluated the association between dietary intake of phylloquinone (vitamin K1) and menaquinones (vitamin K2) and total and advanced prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. At baseline, habitual dietary intake was assessed by means of a food frequency questionnaire. Dietary intake of phylloquinone and menaquinones (MK-4-14) was estimated by using previously published HPLC-based food-content data. Multivariate-adjusted relative risks of total and advanced prostate cancer in relation to intakes of phylloquinone and menaquinones were calculated in 11,319 men by means of Cox proportional hazards regression.
Results: During a mean follow-up time of 8.6 years, 268 incident cases of prostate cancer, including 113 advanced cases, were identified. Researchers observed a non-significant inverse association between total prostate cancer and total menaquinone intake, specifically linked to a 35% reduction in risk for prostate cancer. The association was stronger for advanced prostate cancer-with an increased intake of vitamin K2 linked to a 63% reduction in risk. Menaquinones from dairy products had a stronger inverse association with advanced prostate cancer than did menaquinones from meat. Phylloquinone intake was unrelated to prostate cancer incidence.