03.13.06
Indication: Blood pressure
Source: Am Heart J January, 2006;151(1):100.
Research: The purpose of this study was to evaluate the effect of tomato extract on systolic and diastolic blood pressure in grade-1 hypertension (HT), on serum lipoproteins, plasma homocysteine and oxidative stress markers. The single-blind, placebo-controlled trial included 31 subjects with grade-1 HT, without concomitant diseases, who required no antihypertensive or lipid-lowering drug therapy, who were recruited from primary care clinics. The subjects entered a 4-week placebo period, then an 8-week treatment period with tomato extract, 250 mg Lyc-O-Mato and a four-week control period with placebo.
Results: Systolic blood pressure decreased from 144 to 134 mm Hg, and diastolic blood pressure decreased from 87.4 to 83.4 mm Hg. No changes in blood pressure were demonstrated during placebo periods. Thiobarbituric acid-reactive substances, a lipid peroxidation products marker, decreased from 4.58 to 3.81 nmol/mg. No significant changes were found in lipid parameters. The researchers in this study concluded that short-term treatment with antioxidant-rich tomato extract can reduce blood pressure in patients with grade-1 HT, naive to drug therapy. The continuous effect of this treatment and the long-term beneficial effect on cardiovascular risk factors, however, still need to be demonstrated.
Source: Am Heart J January, 2006;151(1):100.
Research: The purpose of this study was to evaluate the effect of tomato extract on systolic and diastolic blood pressure in grade-1 hypertension (HT), on serum lipoproteins, plasma homocysteine and oxidative stress markers. The single-blind, placebo-controlled trial included 31 subjects with grade-1 HT, without concomitant diseases, who required no antihypertensive or lipid-lowering drug therapy, who were recruited from primary care clinics. The subjects entered a 4-week placebo period, then an 8-week treatment period with tomato extract, 250 mg Lyc-O-Mato and a four-week control period with placebo.
Results: Systolic blood pressure decreased from 144 to 134 mm Hg, and diastolic blood pressure decreased from 87.4 to 83.4 mm Hg. No changes in blood pressure were demonstrated during placebo periods. Thiobarbituric acid-reactive substances, a lipid peroxidation products marker, decreased from 4.58 to 3.81 nmol/mg. No significant changes were found in lipid parameters. The researchers in this study concluded that short-term treatment with antioxidant-rich tomato extract can reduce blood pressure in patients with grade-1 HT, naive to drug therapy. The continuous effect of this treatment and the long-term beneficial effect on cardiovascular risk factors, however, still need to be demonstrated.