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    Features

    Cognitive Health: Many Branches to a Complex Tree

    There are plenty of evidence-based nutraceuticals to consider when developing formulations that offer specific cognitive health benefits.

    Cognitive Health: Many Branches to a Complex Tree
    By Gene Bruno, MS, MHS, RH(AHG), VP, Scientific and Regulatory Affairs, NutraScience Labs11.07.22
    When you think about supplements for cognitive health, what are the benefits you aim to get? Improved memory? Recall? Focus/concentration? Learning enhancement? All of the above? There are many nutraceuticals capable of addressing the different branches of the cognitive health tree.

    In 2021, the market size for the category of cognitive health supplements (e.g., brain health, brain boosting, nootropics) was valued at $7.68 billion and is expected to expand at a compound annual growth rate (CAGR) of 8.3% from 2022 to 2030, according to a Grand View Research report.1

    It’s important to note the multi-generational appeal of these products, from Baby Boomers with age-related memory impairment to Gen Z, who want a mental edge in school or in the workplace.

    Memory

    The first branch of the cognitive health tree to examine is memory. Demand for products in this segment is likely a function of age-related memory impairment (ARMI), which is relatively common and should not be confused with Alzheimer’s or other dementias.2 ARMI relates to mild memory problems associated with normal aging (e.g., “Where did I put my keys?”).3 Here are a few of many possible nutraceuticals from which to choose:

    • Wild blueberry, glutathione and L-cysteine: In research, helped improve episodic memory in healthy older people.4
    • Ginkgo biloba leaf extract: In research, helped improve occasional, age-related absent mindedness.5-8
    • Phosphatidylserine: In research, improved memory scores in people with age-related memory impairment.9-10

    Recall

    Initially, recall may sound synonymous with memory. But in this context, we refer to short-term memory issues that aren’t necessarily related to aging and may even be stress-induced and on-the-job related. Nutraceuticals that may help include:

    • Holy basil extract: In research, stressed individuals decreased the intensity of forgetfulness to about one-third of that observed in placebo group.11
    • Silk protein hydrolysate: In research, helped subjects stay more competitive, and perform better on the job by improving memory, while enhancing learning, attention, mathematical ability, and memorization.12
    • Spearmint leaf extract: In research, helped improve overall working memory (i.e., the small amount of information that can be held in mind and used in the execution of cognitive tasks).13
    • Rhodiola rosea root extract: In research, improved capacity for mental work during stress.14-16

    Focus/Concentration

    Concentration means control of attention. It is the ability to focus the mind on one subject, object, or thought, and at the same time exclude from the mind every other unrelated thought, idea, feeling, and sensation. This has advantages on the job, as well as during sports or hobbies requiring focus/concentration (e.g., playing an instrument or video game). Some nutraceutical options include:

    • L-theanine and caffeine: In research, helped maintain focus.17-22
    • Panax quinquefolius root extract: In research, improved reaction time within 60 minutes.23
    • Sage leaf extract: In research, enhanced cognitive function within 60 minutes.24
    • Aronia melanocarpa extract: Potential improvement in focus, energy, concentration, and reaction time scores during gaming.25

    Learning Enhancement

    Remember the term “smart pill”? While just taking a supplement alone won’t make you smarter, per se, it can help you in your endeavor to do so. For example, Bacopa monnieri leaf extract has been studied for improved ability to acquire and retain new memories.26-32 

    Conclusion

    There are many evidence-based nutraceuticals other than those listed here, but hopefully this article provides some food for thought in development of cognitive support formulations.

    About the Author: Gene Bruno, MS, MHS, RH (AHG) is a certified nutritionist and registered herbalist with 42 years of dietary supplement industry experience. He currently serves as both the vice president of scientific and regulatory affairs at NutraScience Labs and professor of nutraceutical science at Huntington University of Health Sciences.

    References

    1. Brain Health Supplements Market Size, Share & Trends Analysis Report By Product (Natural Molecules, Herbal Extract), By Application, By Region, And Segment Forecasts, 2022 – 2030 https://www.grandviewresearch.com/industry-analysis/brain-health-supplements-market
    2. Hanninen, T. et al.  (1996). Prevalence of ageing-associated cognitive decline in an elderly population. Age Ageing. 1996 May;25(3):201-5. https://doi.org/10.1093/ageing/25.3.201
    3. Hedden, T. et al. (2004). Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci. 2004;5:87-96. https://doi.org/10.1038/nrn1323
    4. Whyte, A. et al. (2018). A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults. Nutrients. 2018 May 23;10(6). https://doi.org/10.3390/nu10060660
    5. Sierpina, V. et al. (2003). Ginkgo biloba. American Family Physician. 2003;68(5):923-6. https://www.aafp.org/dam/brand/aafp/pubs/afp/issues/2003/0901/p923.pdf
    6. Kleijnen. J, et al. (1992). Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmacol. 1992;34:352-8. https://doi.org/10.1111/j.1365-2125.1992.tb05642.x
    7. Kleijnen. J, et al. Ginkgo biloba. Lancet. 1992;340:1136–1139. https://www.thelancet.com/pdfs/journals/lancet/PII0140-6736(92)93158-J.pdf
    8. Oken, B. et al. (1998). The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol. 1998;55:1409-15. https://jamanetwork.com/journals/jamaneurology/fullarticle/774397
    9. Kato-Kataoka, A. et al. (2010). Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints. J Clin Biochem Nutr. 2010;47:246–255. https://doi.org/10.3164/jcbn.10-62
    10. Gindin, J. et al. (2009). The effect of plant phosphatidylserine on age-associated memory impairment and mood in the functioning elderly. The Geriatric Institute for Education and Research, and Department of Geriatrics, Kaplan Hospital, Rehovot, Israel. Unpublished report
    11. Saxena, R. (2012). Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2012:894509. https://doi.org/10.1155/2012/894509
    12. Kim, D. et al. (2009). Milk Containing BF-7 Enhances the Learning and Memory, Attention, and Mathematical Ability of Normal Persons. Korean J Food Sci Anim Resour. 2009;29(2):278-282. https://doi.org/10.5851/kosfa.2009.29.2.278
    13. Herrlinger, K. et al. (2018). Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment. J Altern Complement Med. 2018 Jan;24(1):37-47. https://doi.org/10.1089/acm.2016.0379
    14. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000 Oct;7(5):365-71.
    15. Spasov, A. (2000). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9. https://doi.org/10.1016/S0944-7113(00)80078-1
    16. Shevtsov, V. (2003). A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105. https://doi.org/10.1078/094471103321659780
    17. Einöther, S. (2010). L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. Appetite. 2010 Apr;54(2):406-9. https://doi.org/10.1016/j.appet.2010.01.003
    18. Kelly, S. et al. (2008). L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. J Nutr. 2008 Aug;138(8):1572S-1577S. https://doi.org/10.1093/jn/138.8.1572S
    19. Foxe, J. et al. (2012). Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. Neuropharmacology. 2012 Jun;62(7):2320-7. https://doi.org/10.1016/j.neuropharm.2012.01.020
    20. Owen, G. et al. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. 2008 Aug;11(4):193-8. https://doi.org/10.1179/147683008X30151321. Giesbrecht, T. et al. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci. 2010 Dec;13(6):283-90. https://doi.org/10.1179/147683010X12611460764840
    22. De Bruin, E. et al. (2011). Black tea improves attention and self-reported alertness. Appetite. 2011 Apr;56(2):235-40. https://doi.org/10.1016/j.appet.2010.12.011
    23. Scholey, A. et al. (2010). Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology. 2010;212:345–356. https://doi.org/10.1007/s00213-010-1964-y
    24.  Scholey, A. et al. (2008). An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology (Berl) 2008;198(1):127-139. https://doi.org/10.1007/s00213-008-1101-3
    25. (2021). Proprietary Aronia berry extract improves acute and short-term gaming performance in a young, healthy gamer population: study report. BioActor B.V.  Brightlands Health Campus Gaetano Martinolaan 85, 6229GS Maastricht, Netherlands. Unpublished. March 29, 2021: 19 pgs.
    26. Morgan, A., et al. (2010). Does Bacopa monnieri Improve Memory Performance in Older Persons? Results of a Randomized, Placebo-Controlled, Double-Blind Trial. J Altern Complem Med. 2010; 16(7): 753–759. https://doi.org/10.1089/acm.2009.0342
    27. Calabrese, C. et al. (2008). Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial. J Altern Complem Med. 2008;14(6):707–713. https://doi.org/10.1089/acm.2008.0018
    28. Roodenrys, S. et al. (2002).Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology. 2002 Aug;27(2):279-81. https://doi.org/10.1016/S0893-133X(01)00419-5
    29. Stough, C. et al. (2001). The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl). 2001 Aug;156(4):481-4. https://doi.org/10.1007/s002130100815
    30. Stough, C. et al. (2008). Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 2008 Dec;22(12):1629-34. https://doi.org/10.1002/ptr.2537
    31. Raghav, S. et al. (2006). Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry. 2006 Oct-Dec; 48(4): 238–242. https://doi.org/10.4103/0019-5545.31555
    32. Pase, M. (2012). The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. 2012 Jul;18(7):647-52. https://doi.org/10.1089/acm.2011.0367
     
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