Indication: Prostate Health
Source: British Journal of Nutrition, doi:10.1017/S0007114512004783.
Research: The main objective of this study was to determine the potential of omega 3 and omega 6 fatty acids or Coenzyme Q10 (CoQ10) to alter serum prostate-specific antigen (PSA) levels in normal healthy men. A total of 504 healthy men with serum PSA level ≤ 2.5 ng/ml were recruited. Serum PSA values were not segregated by decade of age. Participants were randomly assigned to receive either 4.48 grams of EPA plus 2.88 grams of DHA, 2.4 grams of omega 6 fatty acid gamma-linolenic acid (GLA) or 400 mg of CoQ10 or placebo daily for 12 weeks. Serum levels of PSA, EPA, DHA, GLA, lipid profile and reproductive hormones were also measured.
Results: EPA treatment significantly reduced serum PSA level by 30% (95% CI 25, 36) (P = 0.004) from baseline. In contrast, GLA therapy significantly increased serum PSA concentration by 15% (95% CI 11, 20) (P = 0.02). CoQ10 therapy also significantly reduced serum PSA level by 33% (95% CI 27, 40) (P = 0.02). In multivariable analysis, serum values of PSA were strongly correlated with duration of EPA, omega 6 and CoQ10 use. There were also significant correlations between serum values of DHA, EPA, GLA and CoQ10 and serum PSA levels. Researchers concluded this study demonstrates that dietary supplements containing EPA, GLA or CoQ10 may significantly affect serum PSA levels.