• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains

    Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality

    Nutrition and Flavor: Formulating for Modern Product Preferences

    What Do Consumers Know About the Gut Microbiome?

    How Will the European Green Deal Impact Dietary Supplements?
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Icon Foods Appoints Operations and Marketing Leaders

    Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD

    GC Rieber VivoMega Continues to Find Operational Efficiencies, Minimize Environmental Impact

    Vitamin A Deficiency: 53% of Primary School Children in Rural Malaysia Found to be Malnourished

    PLT to Supply Traceable, Standardized Organic Elderberry Extract
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Icon Foods Appoints Operations and Marketing Leaders

    Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD

    GC Rieber VivoMega Continues to Find Operational Efficiencies, Minimize Environmental Impact

    Vitamin A Deficiency: 53% of Primary School Children in Rural Malaysia Found to be Malnourished

    PLT to Supply Traceable, Standardized Organic Elderberry Extract
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Icon Foods Appoints Operations and Marketing Leaders

    Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD

    Vitamin A Deficiency: 53% of Primary School Children in Rural Malaysia Found to be Malnourished

    PLT to Supply Traceable, Standardized Organic Elderberry Extract

    Herbalist and Alchemist Celebrates 40th Anniversary, Announces Expansion
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD

    Vitamin A Deficiency: 53% of Primary School Children in Rural Malaysia Found to be Malnourished

    PLT to Supply Traceable, Standardized Organic Elderberry Extract

    Vitamin K2 May Ameliorate Polycystic Ovary Syndrome

    Vitamin D May Prevent Changes to Liver Enzymes and Lipid Profile After Exhaustive Exercise
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Xsto Solutions

    Nutrition21, LLC

    PhytoGaia Inc

    BGG World

    Botanic Healthcare LLC
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Xsto Solutions

    Nutrition21, LLC

    PhytoGaia Inc

    BGG World

    Botanic Healthcare LLC
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Online Exclusives

    CRN Takes Issue with Analysis’ Representation of Brain Health Supplements

    The trade association argued this analysis by Pieter Cohen and others “unfairly maligns” and “misrepresents” the cognitive support category.

    CRN Takes Issue with Analysis’ Representation of Brain Health Supplements
    Out of all supplements tested, 10 products contained five different drugs, as either declared or undeclared ingredients at pharmacological doses.
    Related CONTENT
    • GOED Publishes Methodology Behind Clinical Study Database
    • CRN Announces New Staff Appointments
    • Food Supplements Europe: Most Consumers Use Dietary Supplements Safely
    • CHPA Hires Two Key Personnel
    • AHPA: Expect Initial Cost of Mandatory Product Listing to Reach Nearly $20 Million
    By Mike Montemarano, Associate Editor10.16.20
    The Council for Responsible Nutrition (CRN), a trade organization representing the dietary supplements industry, recently took issues with the way an analysis published in Neurology Clinical Practice portrayed the state of the cognitive support supplements category.
     
    The analysis, authored by Pieter A. Cohen, MD, from Harvard Medical School, et al, “Five unapproved drugs found in cognitive enhancement supplements,” stated that its objective was to identify the presence of unapproved pharmaceutical drugs in over-the-counter dietary supplements marketed to improve memory and cognitive function. The authors of the study used two supplement databases to identify products containing either omberacetam, aniracetam, phenylracetam, or oxiracetam, four drugs classified as piracetam analogues which are not approved for human use in the U.S.
     
    Piracetam analogs are used in select countries as medications used to treat a number of neurological disorders or injuries.
     
    The supplement databases used in the study were the National Institutes of Health’s (NIH) Dietary Supplement Label Database, and the Natural Medicines Database.
     
    Racetams don’t have a universally-accepted mechanism of action, though, they are considered nootropics with stimulating effects.
     
    The authors then tested 10 products, using non-targeted liquid chromatography, and were able to detect omberacetam and aniracetam, in addition to three other unapproved ingredients: phenibut, vinpocetine, and picamilon—each of which have been associated with adverse effects in clinical settings, the authors said.
     
    Phenibut is a central nervous system depressant, believed to have anxiolytic effects, though it is not approved or available as a medication in the E.U, the U.S., or Australia. Though it has apparent recreational potential, it is not classified as a controlled substance. Vinpocetine is a man-made chemical resembling an extract found in the periwinkle plant, and while preliminary evidence suggests it may have some neuroprotective benefits, the the U.S. Food and Drug Administration said it is ineligible to be marketed as a dietary supplement. Picamilon is a combination of GABA and niacin, and is sold in Russia as a prescription drug; it has been deemed by FDA as an adulterating agent in dietary supplements.
     
    Several of the detected drugs were not declared on the label of these products, and several declared ingredients were not detected in the products. Many of the drugs that these tested products contained met or exceeded pharmacological doses in the recommended serving sizes. For products with quantities provided on labels, 75% of the declared quantities were inaccurate, the analysis alleged.
     
    “Consumers cannot obtain accurately labeled cognitive enhancement supplements by selecting supplements using the NIH’s or Natural Medicines’ supplement databases,” the authors of the analysis said. “Previous research found similar discrepancies between the information provided in the NIH’s supplement database compared to the actual content of the supplement. Use of these cognitive enhancement supplements poses potentially serious health risks given the unpredictable dosing and lack of clinician supervision.”
     
    CRN Responds
    Steve Mister, president and CEO of CRN, said the authors of this study made sweeping conclusions about the brain health category based upon a narrow selection of 10 illegal products on the Internet.
     
    “The results of this exercise by Dr. Cohen et al. demonstrate this unfortunate, but unsurprising truth: when researchers—or consumers—with access to an online search engine go looking for illegal products posing as brain health supplements, they are likely to find them,” Mister said. “Fortunately for consumers, this small collection does not represent the brain health supplement category, as the products identified in this study are not legal dietary supplements, but illegal products containing unapproved drugs. Evidence indicates nutrients are essential for brain health whether achieved through diet or supplementation.”
     
    Additionally, he took issue with the characterization of supplement databases as “shopping tools for the public,” but rather that they are intended to provide a full picture of both high-quality and adulterated substances.
     
    “They fail to recognize that the dietary supplement databases they examined, as well as the industry’s own voluntary registry, the Supplement OWL, must include the good, the bad, and the ugly to provide an accurate representation of all products on the market,” Mister said. “No one questions that products that contain illegal drug ingredients are not legal dietary supplements. However, although the analysis demonstrates that illegal products can be found, especially when sought after, it does not mean consumers cannot find safe and high quality dietary supplement products in the market.”
     
    Despite this, CRN does agree with the study’s conclusion, that the U.S. FDA must increase its enforcement of dietary supplement regulation. “Until FDA enforcement efforts predictably and consistently provide deterrence to drive these illegal products from the market, we should not be surprised that they exist in the corners of the Internet,” Mister said.
     
    Related Searches
    • Cognitive Function
    • Quality & Safety
    • Testing
    • Dietary Supplements
    Related Knowledge Center
    • Dietary Supplements
    • Quality & Safety
    • Cognitive Function
    Suggested For You
    GOED Publishes Methodology Behind Clinical Study Database GOED Publishes Methodology Behind Clinical Study Database
    CRN Announces New Staff Appointments CRN Announces New Staff Appointments
    Food Supplements Europe: Most Consumers Use Dietary Supplements Safely Food Supplements Europe: Most Consumers Use Dietary Supplements Safely
    CHPA Hires Two Key Personnel CHPA Hires Two Key Personnel
    AHPA: Expect Initial Cost of Mandatory Product Listing to Reach Nearly $20 Million AHPA: Expect Initial Cost of Mandatory Product Listing to Reach Nearly $20 Million
    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe
    ABC Elects Three New Members to Board of Trustees ABC Elects Three New Members to Board of Trustees
    The Nuts and Bolts of FDA’s 2023 Budget Request The Nuts and Bolts of FDA’s 2023 Budget Request
    AHPA Holds 2022 Awards Ceremony  AHPA Holds 2022 Awards Ceremony
    FSE Marks 20th Year of European Food Supplements Directive FSE Marks 20th Year of European Food Supplements Directive
    Insights on Building Strong Specialty Nutraceutical Categories Insights on Building Strong Specialty Nutraceutical Categories
    NPA Appoints Douglas Kalman, PhD, as Director of Scientific Affairs NPA Appoints Douglas Kalman, PhD, as Director of Scientific Affairs
    GOED Launches Omega-3 Clinical Study Database GOED Launches Omega-3 Clinical Study Database
    Regulatory Future of NAC Supplements Remains Unclear Regulatory Future of NAC Supplements Remains Unclear
    Open Book Extracts Expands Business, Regulatory Team to Focus on European Market Open Book Extracts Expands Business, Regulatory Team to Focus on European Market

    Related Breaking News

    • Breaking News | Industry & Market News | Omega-3s | Research
      GOED Publishes Methodology Behind Clinical Study Database

      GOED Publishes Methodology Behind Clinical Study Database

      The trade association provided transparency behind the methods used for its data collection and aggregation.
      07.07.22

    • Breaking News | Industry & Market News | Quality & Safety | Regulations
      CRN Announces New Staff Appointments

      CRN Announces New Staff Appointments

      The new hires of Mike Meirovitz, Erin Storer, and Anthony Esteban round out CRN's team to 20 total staff positions.
      07.05.22

    • Breaking News | Consumer Trends | Dietary Supplements | Industry & Market News | World Markets
      Food Supplements Europe: Most Consumers Use Dietary Supplements Safely

      Food Supplements Europe: Most Consumers Use Dietary Supplements Safely

      Thousands of supplement users from 14 countries reported high rates of interaction with and understanding of product labels.
      07.05.22


    • Breaking News | Dietary Supplements | People News
      CHPA Hires Two Key Personnel

      CHPA Hires Two Key Personnel

      Larisa Pavlick and Kirby Miller will each play strategic roles for the trade association on science-based policy, technical issues, and more.
      06.21.22

    • Breaking News | Dietary Supplements | Industry & Market News
      AHPA: Expect Initial Cost of Mandatory Product Listing to Reach Nearly $20 Million

      AHPA: Expect Initial Cost of Mandatory Product Listing to Reach Nearly $20 Million

      An early estimate reached by the trade association covers only the cost of product data entry for initial compliance.
      05.31.22

    Loading, Please Wait..
    Trending
    • Evolution Nutraceuticals To Discontinue Challenged Claims For ‘Cardio Miracle’ Dietary Supplement
    • Vitamin K2 Status May Impact Blood Pressure And Pulse Wave Velocity
    • Zeus Hygia Launches Muscle Recovery Ingredient, Gremin
    • Study Examines Vitamin K2 Content In Cheese
    • Chenland Nutritionals Self-Affirms GRAS For Cumin UP60 Ingredient
    Breaking News
    • IFIC 2022 Food & Health Survey Highlights Eating Behavior Trends
    • Icon Foods Appoints Operations and Marketing Leaders
    • Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD
    • GC Rieber VivoMega Continues to Find Operational Efficiencies, Minimize Environmental Impact
    • Vitamin A Deficiency: 53% of Primary School Children in Rural Malaysia Found to be Malnourished
    View Breaking News >
    CURRENT ISSUE

    July/August 2022

    • A Growing Herbal Products Market Still Faces Formidable Threats, Challenges
    • Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality
    • Nutrition and Flavor: Formulating for Modern Product Preferences
    • Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains
    • How Will the European Green Deal Impact Dietary Supplements?
    • What Do Consumers Know About the Gut Microbiome?
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Icon Foods Appoints Operations and Marketing Leaders
    Annatto Tocotrienol Shown to Improve Weight Loss and Inflammation Markers in Patients with NAFLD
    GC Rieber VivoMega Continues to Find Operational Efficiencies, Minimize Environmental Impact
    Coatings World

    Latest Breaking News From Coatings World

    Birla Carbon, NREL Collaboration to be Presented at ACS Conference
    Coating Resins Market Worth $70.9 Billion by 2027: MarketsandMarkets
    PPG Appoints Brad Budde Vice President and Chief Digital Officer
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Solid Growth Forecast for Global Ostomy Devices Market
    KA Imaging's Reveal 35C Images Increase Lung Lesion Visibility
    Respira Technologies Appoints Brian Quigley as CEO
    Contract Pharma

    Latest Breaking News From Contract Pharma

    GRAM to Fill and Finish Smallpox/Monkeypox Vaccines
    bluebird bio Wins FDA Approval of ZYNTEGLO
    Pace Life Sciences Acquires Meridian BioGroup
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Sephora at Kohl’s to Expand Sephora Presence to All 1,100+ Kohl’s Locations
    Emma Watson to Front New Fragrance Campaign for Prada
    The Estée Lauder Companies Delivers Strong Results in Fiscal 2022
    Happi

    Latest Breaking News From Happi

    Amorepacific, MIT Develop World's First Chip-less Wireless Electronic Skin Enabled by Semiconductors
    Maesa Launches Itk Skincare with TikTok Stars Brooklyn and Bailey McKnight
    Skin Delivery Formulation
    Ink World

    Latest Breaking News From Ink World

    Xeikon to Introduce TITON Food-Safe Dry-Toner Technology at Labelexpo Americas 2022
    Smurfit Kappa Employees Charity Cycle Across Europe
    ProAmpac’s Rocky Mount, VA Facility Receives ISCC Plus Certification
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Techkon USA announces latest handheld spectrodensitometer
    Maxcess China now manufacturing solid dies in Huzhou
    Avery Dennison debuts new adhesive for wine and spirits
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    INDA Appoints Director of Membership and Industry Relations
    Nexwear Acquires Incontinence Products Brand Lily Bird
    Because Market Expands into Retail Stores
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Theragen Receives Patent for Spine Fusion Bone Growth Stimulator System
    Study: BONESUPPORT’s CERAMENT G Can Help Save Infected Limbs
    Zavation’s Cervical Intervertebral Body Fusion Device Cleared by FDA
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    NREL, Birla Carbon Collaboration to be Shown at ACS Conference
    ORNL Celebrates Launch of Frontier, the World’s Fastest Supercomputer
    DuPont Names 2022 Lavoisier and Pedersen Award Medalists

    Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login