• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains

    Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality

    Nutrition and Flavor: Formulating for Modern Product Preferences

    What Do Consumers Know About the Gut Microbiome?

    How Will the European Green Deal Impact Dietary Supplements?
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients

    IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations

    Caffeine-Free Energy Supplement Linked to Alertness, Fatigue Benefits
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients

    IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations

    Caffeine-Free Energy Supplement Linked to Alertness, Fatigue Benefits
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients

    IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations

    Caffeine-Free Energy Supplement Linked to Alertness, Fatigue Benefits
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Caffeine-Free Energy Supplement Linked to Alertness, Fatigue Benefits

    Monk Fruit Sweetener May Have Prebiotic Activity, Study Finds

    People with Low-Fiber Diets Benefit the Most from Fiber Supplements, Study Finds

    Gut Microbiome May Be Part of Link Between Red Meat and Heart Disease Risk

    Nutritional Growth Solutions’ Healthy Heights Enters South Korea Market
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    BGG World

    JRS Pharma

    Ecuadorian Rainforest

    Atlantia Clinical Trials

    Xsto Solutions
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    BGG World

    JRS Pharma

    Ecuadorian Rainforest

    Atlantia Clinical Trials

    Xsto Solutions
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Online Exclusives

    What is Pterostilbene?

    The berry-derived ingredient is proving to be a potent antioxidant and cardiovascular system supporter.

    Related CONTENT
    • Formulating for Nutrient Bioavailability
    • New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance
    • Can a Simple Vitamin E Keep Cardiometabolic Syndrome at Bay?
    • Next-Gen Sports Nutrition: Performance and Personalization
    • SRW Laboratories Debuts Line of Supplements Targeting Cellular Health
    Joanna Cosgrove04.18.11
    Belonging to the phytoalexin class of compounds, pterostilbene is a protective compound produced by small berry plants like blueberries, cranberries, lingonberries and grapes to ward off the damage of pathogens such as bacteria or fungi. While such a complex biological process might be easy to overlook  in such tiny berries,pterostilbene has been garnering quite a buzz in supplement circles where researchers are comparing its capabilities to those of resveratrol but with some decidedly interesting advantages in the realms of anti-aging, heart health, oxidative stress and memory support.
     
    Pterostilbene and resveratrol both have the same role in the plant’s defense system. “Resveratrol is one of the main phytoalexins in grapes, pterostilbene in blueberries,” explained   Jeremy Bartos, PhD, pTeroPure product manager for ChromaDex of Irvine, CA. “The only difference between the two is the presence of two methoxy groups in pterostilbene (resveratrol has three hydroxyl groups, pterostilbene has one along with the two methoxys). 
     
    It’s the methoxy groups that make all of the difference when it comes to utilizing these compounds in the human body. “Resveratrol has two things going against it,” said Dr. Bartos. “One is the fact that without the methoxy groups it is not as lipophilic (oil-soluble) as pterostilbene, so it’s cellular uptake is much less than pterostilbene - pterostilbene can be taken through the cell’s lipid bi-layer rather easily.” 
     
    The second difference has to do with how pterostilbene is filtered through the human liver. “The liver acts as the gatekeeper to the body; it filters everything that comes through and compounds it does not recognize (such as pharmaceuticals, plant chemicals and toxins) it will tag for elimination from the body,” said Dr. Bartos. “In the case with stilbenes such as resveratrol and pterostilbene the liver will typically glucuronidate (add a glucuronic acid molecule, a compound very similar to glucose) or sulfate any free hydroxyl groups it can find.  Since resveratrol has three hydroxyl groups it is tagged for elimination much quicker and easier than pterostilbene with only one hydroxyl group, leading to a half-life in the blood of ~14 minutes compared to ~105 minutes for pterostilbene.” 
     
    To underscore his comment, Dr. Bartos pointed to a recently published paper which confirmed the bioavailability of pterostilbene as being “three to four times greater than that of resveratrol,” and noted that “systemic exposure to pterostilbene was substantially greater than was systemic exposure to resveratrol.” (Cancer Chemotherapy & Pharmacology, 2010 Nov 30)
     
    Canon of Research
     
    Pterostilbene has been a part of the supplement research vernacular since the early 1990s but only became more well-known inthe mid 2000s.Much of the current pterostilbene research being conducted today mirrors the studies that made resveratrol a household word, Dr. Bartos explained.
     
    A study published by the USDA in 2005 compared both pterostilbene and resveratrol to determine their ability to induce PPAR-alpha activation, which is involved in fatty acid and lipid catabolism and its activation leads to decreased triglyceride and very low density lipoprotein (VLDL) synthesis. “It was shown in the study that pterostilbene activated PPAR-alpha in vitro better than all compounds tested, including both resveratrol and the pharmaceutical ciprofibrate,” said Dr. Bartos. “Subsequent structural and in vivo studies confirmed the correlation between pterostilbene’s activation of PPAR-alpha and cholesterol lowering. In fact, the first human clinical trial on pterostilbene currently underway at the University of Mississippi has cholesterol as its primary endpoint.”
     
    A second study compared the ability of resveratrol and pterostilbene to protect cells against oxidative stress. “A collaboration of scientists from Tufts University and the USDA measured the ability of several plant polyphenols to protect cells from damage caused by oxidative stress and found that while pterostilbene was able to protect the cells, resveratrol was not. This is important for several reasons,” Dr. Bartos recalled. “First of all, the buzz around the industry is ‘anti-oxidant’ and ‘ORAC,’ (Oxygen Radical Absorbance Capacity), a quick and dirty way to measure the potential ability of a compound to neutralize free radicals before they cause oxidative damage.”
     
    The problem with ORAC is that it only measures potential of a compound, not the actual ability, he said. “High ORAC compounds may have all the potential in the world, but if they can’t get to where they need to be in order to do the job they are supposed to be doing (in this case neutralizing free radicals) then the potential is never realized. So it is important to note that scientists went even further to show that pterostilbene’s ability to protect cells from oxidative damage can be seen in animal models as well as cell models. 
     
    “This is important because it shows that pterostilbene has the ability to localize in the places where it can be used,” he continued. “Oxidative damage seems to be at least partially responsible for aging disease such as Alzheimer’s. The scientists showed a direct correlation between the levels of pterostilbene in rat’s hippocampus (memory center of the brain) and their ability to remember how to run a maze, showing that pterostilbene’s protection against oxidative stress can be translated to behavioral changes as well.”
     
    The most noteworthy up and coming pterostilbene studies will focus on sirtuin activation. “One of the latest papers is entitled ‘Pterostilbene Is More Potent than Resveratrol in Preventing Azoxymethane (AOM)-Induced Colon Tumorigenesis via Activation of the NF-E2-Related Factor 2 (Nrf2)-Mediated Antioxidant Signaling Pathway,’ [which] directly compares the abilities of pterostilbene and resveratrol to inhibit the formation of colon tumors in mice based on their anti-oxidant abilities alone,” said Dr. Bartos. “They found that while both pterostilbene and resveratrol were able to inhibit tumor formation by enhancing expression of antioxidant enzymes via activation of the Nrf2 protein, pterostilbene was significantly more potent than resveratrol.”
     
    Market Potential
     
    Because pterostilbene is still in its relative infancy, its market size and potential is somewhat difficult to calculate. Dr. Bartos said the first pterostilbene products were rolled out directly to physicians. Niche mail and Internet order markets are the next distribution phase, with retail venues as phase three. ChromaDex’s pTeroPure brand pterostilbene enjoyed a retail debut earlier this year and has steadily gained traction with larger retail companies—a phenomenon that should be bolstered over the next few weeks when the ingredient attains self-affirmed Generally Recognized As Safe (GRAS) status.
     
    “With this hurdle behind, pTeroPure is no longer limited to the nutraceutical market and can be included in functional foods such as granola bars, cereal, yogurt, etc.,” said Dr. Bartos. “Imagine a cheese product that contains an ingredient that can improve your heart health, or a cookie that contains a compound used for centuries to support blood sugar levels.” 
     
    Research has suggested that pterostilbene and resveratrol can also work synergistically to protect cells from damage caused by oxidative stress and, in fact, may be more effective together than if used separately. To that end, last month Nutraceutical International Corporation added a new resveratrol and pTeroPure pterostilbene combination product to its Solaray Guaranteed Potency line of products.
     
    In addition to the supplement market, ChromaDex also has high expectations for success with pTeroPure in the cosmetics market. “Because pterostilbene is lipophilic (oil-soluble), not only is it compatible with oil-based creams, but it also has fantastic uptake in to the cells because it can easily get through the cell’s lipid bilayer,” Dr. Bartos said. “This allows the ability to absorb a powerful anti-oxidant right into the skin where it can work to limit damage associated with aging. Recent experiments with the bacteria that causes acne have also shown promise.”
    Related Searches
    • Fatty Acid
    • Stress
    • Nutraceutical
    • Functional Foods
    Related Knowledge Center
    • Enzymes
    • Healthy Aging
    • Cardiovascular Health
    Suggested For You
    Formulating for Nutrient Bioavailability Formulating for Nutrient Bioavailability
    New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance
    Can a Simple Vitamin E Keep Cardiometabolic Syndrome at Bay? Can a Simple Vitamin E Keep Cardiometabolic Syndrome at Bay?
    Next-Gen Sports Nutrition: Performance and Personalization Next-Gen Sports Nutrition: Performance and Personalization
    SRW Laboratories Debuts Line of Supplements Targeting Cellular Health SRW Laboratories Debuts Line of Supplements Targeting Cellular Health
    Heart Health Dietary Supplement Market Influences & Opportunities Heart Health Dietary Supplement Market Influences & Opportunities
    Identifying Adulterated Curcumin: Case Study Identifies Best Testing Methods Identifying Adulterated Curcumin: Case Study Identifies Best Testing Methods
    Beauty Ingredient Formulation Directory Fall 2021 Beauty Ingredient Formulation Directory Fall 2021
    Annatto Tocotrienol, Vitamin D & Resveratrol May Offer Blood Sugar Benefits, Reduce Inflammation Annatto Tocotrienol, Vitamin D & Resveratrol May Offer Blood Sugar Benefits, Reduce Inflammation
    Trans-Resveratrol Hesperetin Combination Linked to ‘Reversals’ of Insulin Resistance Trans-Resveratrol Hesperetin Combination Linked to ‘Reversals’ of Insulin Resistance
    Nutricosmetics Reflect Wellness Inside-Out Nutricosmetics Reflect Wellness Inside-Out
    Humann Launches New SuperBeets Memory & Focus Chews Humann Launches New SuperBeets Memory & Focus Chews
    Resveratrol Evidenced to Reduce Markers of Endometriosis Progression in Women Resveratrol Evidenced to Reduce Markers of Endometriosis Progression in Women
    Antioxidants Adapt to New Growth Avenues Antioxidants Adapt to New Growth Avenues
    Gencor Announces Positive Results in VeriSperse Bioavailability Study Gencor Announces Positive Results in VeriSperse Bioavailability Study

    Related Online Exclusives

    • Antioxidants | Delivery & Dosage Technologies | Fiber & Carbohydrates | Functional Foods & Beverages | Research
      Formulating for Nutrient Bioavailability

      Formulating for Nutrient Bioavailability

      At IFT FIRST, food scientists discussed innovation and insights into how we digest, absorb, and utilize nutrients.
      By Mike Montemarano, Associate Editor 08.09.22

    • Consumer Trends | Diabetes & Blood Sugar Management | Functional Foods & Beverages | Healthcare Trends | Sweeteners
      New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance

      New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance

      Allulose, stevia, monk fruit, and more help brands reduce sugar while supplements offer consumers additional solutions.
      By Danielle Rose, Contributing Writer 06.02.22

    • Antioxidants | Cardiovascular Health | Diabetes & Blood Sugar Management | Healthy Aging | Inflammation | Research | Vitamins
      Can a Simple Vitamin E Keep Cardiometabolic Syndrome at Bay?

      Can a Simple Vitamin E Keep Cardiometabolic Syndrome at Bay?

      Research continues to write the success story of tocotrienol.
      By Anne Trias, MS, American River Nutrition 03.02.22


    • Delivery & Dosage Technologies | Dietary Supplements | Research | Sports Nutrition
      Next-Gen Sports Nutrition: Performance and Personalization

      Next-Gen Sports Nutrition: Performance and Personalization

      Formulators are building up the latest iteration of products to include a range of benefits with sophisticated, science-based ingredients.
      By Mike Montemarano, Associate Editor 03.02.22

    • Antioxidants | Breaking News | Delivery & Dosage Technologies | Dietary Supplements | Energy | Healthy Aging | Immune Function | Inflammation | Medical Nutrition | Products | Research
      SRW Laboratories Debuts Line of Supplements Targeting Cellular Health

      SRW Laboratories Debuts Line of Supplements Targeting Cellular Health

      The range of three products features hobamine, a novel ingredient tied to DNA protection and antioxidant activity, alongside several other emerging ingredients.
      By Mike Montemarano, Associate Editor 11.18.21

    Loading, Please Wait..
    Trending
    • First Day Life Shuts Down Children's Behavioral, Cognitive Health Claims Following Challenge
    • Study Examines Vitamin K2 Content In Cheese
    • Chenland Nutritionals Self-Affirms GRAS For Cumin UP60 Ingredient
    • Pycnogenol Evidenced To Have Skin Benefits In Dermatology Study
    Breaking News
    • ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    • Tazo Transitions to Regenerative Organic Agriculture
    • Protein Ingredient Formulated for Chronic Kidney Disease Patients
    • IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    • Caffeine-Free Energy Supplement Linked to Alertness, Fatigue Benefits
    View Breaking News >
    CURRENT ISSUE

    July/August 2022

    • A Growing Herbal Products Market Still Faces Formidable Threats, Challenges
    • Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality
    • Nutrition and Flavor: Formulating for Modern Product Preferences
    • Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains
    • How Will the European Green Deal Impact Dietary Supplements?
    • What Do Consumers Know About the Gut Microbiome?
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    Tazo Transitions to Regenerative Organic Agriculture
    Protein Ingredient Formulated for Chronic Kidney Disease Patients
    Coatings World

    Latest Breaking News From Coatings World

    USGBC Urges the House to Pass the Inflation Reduction Act
    The ChemQuest Technology Institute Enters Agreement with Universal Matter
    Sherwin-Williams’ TERRA: Embracing Community & Connection in 2023
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Seno Medical's Imagio System Wins Supplemental FDA Approval
    Brad Fluegel Joins NeuroMetrix Board of Directors
    Actuating Implant Design Prevents Scar Tissue Buildup
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Captor Therapeutics Selects CDMO for Clinical Trial Materials
    Catalent to Acquire Metrics Contract Services for $475M
    Sartorius Stedim Biotech Agrees to Acquire Albumedix
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Anomatic & Novelis Introduce Eco-Friendly Alloy
    NJPEC Announces 2022 Package of the Year Awards
    Tree Hut Introduces New Sugar Scrubs
    Happi

    Latest Breaking News From Happi

    Makeup in New York Returns to the Javits Center on Sept. 14-15
    PASS Coalition Applauds National Academy of Sciences Study on Its Support of Sunscreen as a Skin Cancer Prevention Tool
    Sally Beauty Names Winners of 2022 Cultivate Accelerator Program
    Ink World

    Latest Breaking News From Ink World

    INX to Highlight New Products at Labelexpo Americas
    Sonoco Names Aditya Gandhito Company’s First Chief Accounting Officer
    Quinacridone Pigments Market Size Projected to Reach $539 Million by 2030: Straits
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Heidelberg USA-Gallus opens new Screeny Demo Room in Pennsylvania
    Heidelberg enjoys successful start to financial year
    INX International Ink Co. brings wide product range to Labelexpo Americas
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Vapor Fresh Upgrades Plant-Based Gym Wipe Canisters
    Suominen Releases Half-Year Financial Report
    Essity Switches to Recyclable Packs for Feminine Pads
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Cortland Biomedical Adds Suite of Post-Processing Services & Technologies
    First Patient Enrolls in Sonex Health’s U.S. Clinical Study to Treat Carpal Tunnel Syndrome
    Robust Growth Forecast for Joint Reconstruction Market
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Stratasys Signs Agreement to Acquire Covestro’s Additive Manufacturing Materials Business
    The Future of Electronics RESHAPED Event Reports High Demand
    SEMI Applauds President Biden’s Signing of CHIPS and Science Act of 2022

    Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login